Abstract: A waste disposal system with flexible tubing comprising a container defining a waste chamber; a lid connected to the container and movable between an open condition and a closed condition; an iris with a first disk, a second disk and a web connecting the disks; a cartridge of flexible tubing removably situated in the container, extending from the cartridge through the iris into the waste chamber and positioned to receive waste therein; and a guide system, causing the iris to close by rotating one disk in relation to the other, thereby twisting and cinching the flexible tubing and enclosing the held waste, the guide system further causing the iris to displace in a direction opposite to the lid and to carry the held waste into the waste chamber.