Abstract: The present invention relates to non-psychoactive derivatives of tetrahydrocannabinol, (3R,4R)-?8-THC-11-oic acids, for treating or preventing nausea and relieving symptoms thereof.

Abstract: The present invention relates to non-psychoactive cannabinol analogs of tetrahydrocannabinol, (3R,4R)-?8—THC-11-oic acids, for treating and preventing nausea and relieving symptoms thereof.

Abstract: An anti-muscarinic agent exemplified by trospium is administered by intravesicular instillation into the bladder and used to treat interstitial cystitis. The instilled medication does not interact systemically with the patient; the localized effect of the medication avoids any question of systemic side effects or untoward reactions with body organs or systems.

Abstract: The present invention relates to non-psychoactive derivatives of tetrahydrocannabinol, which are useful in treating interstitial cystitis and relieving symptoms thereof. The invention uses cannabinol analogs, which are preferably analogs of (6aR,10aR)-?8-tetrahydrocannabinol-11-oic acids [hereinafter referred to as (6aR,10aR)-?8-THC-11-oic acid], as well as pharmaceutical compositions containing the cannabinol analogs and analogs of (6aR,10aR)-?8-THC-11-oic acids, for treatment of interstitial cystitis in a mammal. The invention further covers methods of formulating and administering the compounds and pharmaceutical compositions as therapeutic agents in the treatment of interstitial cystitis, with particularly preferred administration routes being oral and via intravesicular instillation.

Abstract: The present invention relates to non-psychoactive derivatives of tetrahydrocannabinol, which are useful in treating interstitial cystitis and relieving symptoms thereof. The invention uses (6aR,10aR)-?8-tetrahydrocannabinol-11-oic acids (hereinafter referred to as (6aR,10aR)-?8-THC-11-oic acid), as well as pharmaceutical compositions containing the (6aR,10aR)-?8-THC-11-oic acids, for treatment of interstitial cystitis in a mammal. The invention further covers methods of formulating and administering the compounds and pharmaceutical compositions as therapeutic agents in the treatment of interstitial cystitis, with particularly preferred administration routes being oral and via intravesicular instillation.

Abstract: A transdermal delivery system for pyrrole derivatives of formula 1, metabolites thereof, enantiomers thereof, racemates thereof, and salts including acid addition salts thereof, alone or in conjunction with one or more other therapeutic agents, using vehicles selected to enhance absorption and which enable the compounds to be administered into and through the skin when topically applied.

Abstract: A method of promoting sleep in a patient with overactive bladder, comprising: administering trospium chloride at or shortly before bedtime, to a patient with overactive bladder disease, in an amount sufficient to reduce wakefulness throughout the patient's normal sleep period.