Patents by Inventor Bodo Asmussen

Bodo Asmussen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6770300
    Abstract: The invention relates to porous, rapidly disintegrating, active substance-containing pellets based on chitosan or a basic chitosan derivative, manufactured according to a dripping method wherein an aqueous solution or dispersion of chitosan or a basic chitosan derivative, one or more active substances, possibly further active substances and an acid is dripped into a cooling liquid having a temperature of maximally −5° C., thereby causing solidification of the solution or dispersion in the form of droplets, and wherein the solidified droplets or pellets are isolated and dried. The invention further relates to the use of these pellets in the manufacture of medicaments or diagnostic agents.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: August 3, 2004
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Hans-Rainer Hoffmann, Bodo Asmussen
  • Publication number: 20040137174
    Abstract: The invention relates to a gastric juice-resistant device for releasing active substance excipients having delayed intestinal passage from a gastric juice-resistant enclosure, and which serves to increase the active substance concentration in the intestines. The inventive device is characterised in that the active substance excipient containing at least one active substance is provided in the form of a multiparticulate preparation whose individual particles have mucoadhesive properties. The invention also relates to a method for producing said device.
    Type: Application
    Filed: December 30, 2003
    Publication date: July 15, 2004
    Inventors: Despina Solomonidou, Markus Krumme, Bodo Asmussen, Joerg Kreuter
  • Publication number: 20040024003
    Abstract: A flat pharmaceutical preparation which is able to disintegrate in aqueous media and is in the form of a sheet, film, paper or wafer for transmucosal administration of active ingredients in the oral cavity, is characterized by a content of oxycodone, or an active ingredient comparable to oxycodone, or a therapeutically suitable salt of oxycodone or of the pharmacologically comparable active ingredient.
    Type: Application
    Filed: July 11, 2003
    Publication date: February 5, 2004
    Inventors: Bodo Asmussen, Markus Krumme
  • Patent number: 6630149
    Abstract: A form of administration for medical active agents in the form of a blister is characterized in that it contains a transdermal therapeutic system and at least one single dose form of the active agent next to each other.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: October 7, 2003
    Assignee: LTS Lohmann Therapie Systeme AG
    Inventors: Wolfgang Schaefer, Hanshermann Franke, Bodo Asmussen
  • Patent number: 6627631
    Abstract: Desoxypeganine and its pharmaceutically acceptable acid addition salts can be used in the treatment of alcoholism. Said substances are administered preferably in a continuos and controlled manner. The pharmaceutical administration form enables controlled release, e.g. for oral, transdermal or another route of parenteral administration.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: September 30, 2003
    Assignees: LTS Lohmann Therapie-Systeme AG, He Arzneimittelforschung GmbH
    Inventors: Bodo Asmussen, Thomas Hille, Hans-Rainer Hoffmann, Klaus Opitz
  • Patent number: 6623763
    Abstract: A pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system, for the release of the active substance 17-&bgr;-estradiol, contained therein in dissolved form being between its saturation concentration in equilibrium with a gas phase of less than 10% relative air humidity and its saturation concentration in equilibrium with a gas phase of more than 90% relative air humidity, in all matrix levels and, if present, also in an adhesive layer, characterized in that the estradiol quantity contained in in the preparation amounts to at least three times the saturation solubility measured at 95% relative air humidity, and that the air enclosed in the package is adjusted to a relative air humidity between 5% and below 0.5%.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: September 23, 2003
    Assignee: LTS Lohmann Therape-System AG
    Inventors: Bodo Asmussen, Michael Horstmann
  • Patent number: 6599511
    Abstract: Desoxypeganine and its pharmaceutically acceptable acid addition salts can be used in the treatment of drug addiction or drug dependence. Said substances are administered preferably in a continuos and controlled manner. The pharmaceutical administration form enables controlled release, e.g. for oral transdermal or another route of parenteral administration.
    Type: Grant
    Filed: October 17, 2001
    Date of Patent: July 29, 2003
    Assignees: LTS Lohmann Therapie-Systeme AG, HF Aezneimittelforschung GmbH
    Inventors: Bodo Asmussen, Thomas Hille, Hans-Rainer Hoffmann, Klaus Opitz
  • Patent number: 6548510
    Abstract: Desoxypeganine and its pharmaceutically acceptable acid addition salts are useful in treating nicotine dependence.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: April 15, 2003
    Assignees: LTS Lohmann Therapie Systeme AG, HF Arzneimittelforschung GmbH
    Inventors: Bodo Asmussen, Thomas Hille, Hans-Rainer Hoffmann, Klaus Opitz
  • Publication number: 20030008852
    Abstract: The use of acetylsalicylic acid for the treatment of migraine and other serotonin-dependent, platelet-mediated disorders is characterized in that the active ingredient is administered with the aid of a transdermal therapeutic system (TTS).
    Type: Application
    Filed: August 12, 2002
    Publication date: January 9, 2003
    Inventors: Franke Hanshermann, Bodo Asmussen
  • Patent number: 6436937
    Abstract: The invention relates to a device and method for the treatment of Alzheimer's dementia with desoxypeganine and/or a pharmaceutically acceptable acid addition salt of desoxypeganine.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: August 20, 2002
    Assignee: LTS Lohman-Therapie Systeme AG
    Inventors: Bodo Asmussen, Thomas Hille, Hans-Rainer Hoffmann, Klaus Opitz
  • Patent number: 6379696
    Abstract: A therapeutic preparation for the transdermal application of active substances through the skin comprising additives causing an increase in the percutaneous absorption rate of active substances which can normally only insufficiently be absorbed transdermally is characterized by the fact that the additives are HMG-CoA-reductase-inhibitors.
    Type: Grant
    Filed: May 5, 1998
    Date of Patent: April 30, 2002
    Assignee: LTS Lohmann Therapie-System Gmbh
    Inventors: Bodo Asmussen, Andreas Koch, Rudolf Matusch
  • Patent number: 6335031
    Abstract: Pharmaceutical composition comprising (S)-N-ethyl-3-[1-dimethylamino)ethyl]-N-methyl-phenyl-carbamate in free base or acid addition salt form and an anti-oxidant. Said pharmaceutical compositions may be delivered to a patient using a transdermal delivery device.
    Type: Grant
    Filed: April 14, 1999
    Date of Patent: January 1, 2002
    Assignees: Novartis AG, LTS Lohmann Therapie-Systeme GmbH Co. KG
    Inventors: Bodo Asmussen, Michael Horstmann, Kai Köpke, Henricus L. G. M. Tiemessen, Steven Minh Dinh, Paul M. Gargiulo
  • Patent number: 6333048
    Abstract: In a solid medicament form for the peroral application of active agents containing a uniform distribution of active agent in a polymer material, the polymer material is in the form of flat fragments.
    Type: Grant
    Filed: July 10, 1997
    Date of Patent: December 25, 2001
    Assignee: LTS Lohmann Therapie-Systeme GmbH
    Inventors: Bodo Asmussen, Walter Müller, Karsten Cremer
  • Publication number: 20010048938
    Abstract: Pharmaceutical composition comprising (S)-N-ethyl-3-[1-dimethylamino)ethyl]-N-methyl-phenyl-carbamate in free base or acid addition salt form and an anti-oxidant. Said pharmaceutical compositions may be delivered to a patient using a transdermal delivery device.
    Type: Application
    Filed: December 20, 2000
    Publication date: December 6, 2001
    Inventors: Bodo Asmussen, Michael Horstmann, Kai Kopke, Henricus L.G.M. Tiemessen, Steven Minh Dinh, Paul M. Gargiulo
  • Publication number: 20010043944
    Abstract: A pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system, for the release of the active substance 17-&bgr;-estradiol, contained therein in dissolved form being between its saturation concentration in equilibrium with a gas phase of less than 10% relative air humidity and its saturation concentration in equilibrium with a gas phase of more than 90% relative air humidity, in all matrix levels and, if present, also in an adhesive layer, characterized in that the estradiol quantity contained in in the preparation amounts to at least three times the saturation solubility measured at 95% relative air humidity, and that the air enclosed in the package is adjusted to a relative air humidity between 5% and below 0.5%.
    Type: Application
    Filed: June 19, 2001
    Publication date: November 22, 2001
    Inventors: Bodo Asmussen, Michael Horstmann
  • Patent number: 6316023
    Abstract: Pharmaceutical composition comprising (S)-N-ethyl-3-[1-dimethylamino)ethyl]-N-methyl-phenyl-carbamate in free base or acid addition salt form and an antioxidant. Said pharmaceutical compositions may be delivered to a patient using a transdermal delivery device.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: November 13, 2001
    Assignees: Novartis AG, LTS Lohmann Therapie-Systeme GmbH
    Inventors: Bodo Asmussen, Michael Horstmann, Kai Köpke, Henricus L. G. M. Tiemessen, Steven Minh Dinh, Paul M. Gargiulo
  • Patent number: 6290989
    Abstract: The present invention describes a device for the controlled release of active compounds in the gastrointestinal tract with delayed pyloric passage, having a component expandable on contact with gastric juice, which is surrounded by a polymer covering which is permeable to gastric juice and active compounds. The device contains at least one active compound which is present in a multiparticulate preparation which releases the active compound into the gastric juice with a delay. Compared with conventional pharmaceutical forms with delayed pyloric passage, the release of active compound from a device according to the invention can be better controlled; likewise the device can be easily rolled or folded and can be introduced into capsules without problems.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: September 18, 2001
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Bodo Asmussen, Karsten Cremer, Hans-Rainer Hoffmann, Karin Ludwig, Michael Roreger
  • Patent number: 6267982
    Abstract: A pharmaceutical preparation adhering to the skin, in particular a TTS, for the release of the active substance 17-&bgr;-estradiol, the concentration of the estradiol contained therein in dissolved form being between its saturation concentration in equilibrium with a gas phase of less than 10% relative air humidity and its saturation concentration in equilibrium with a gas phase of more than 90% relative air humidity, in all matrix layers and, if present, also in an adhesive layer, characterized in that the estradiol quantity contained in the preparation amounts to at least three times the saturation solubility measured at 95% relative air humidity, and that the air enclosed in the package is adjusted to a relative air humidity between 5% and below 0.5%.
    Type: Grant
    Filed: March 17, 1999
    Date of Patent: July 31, 2001
    Assignee: LTS Lohman Therapie-Systeme GmbH
    Inventors: Bodo Asmussen, Michael Horstmann
  • Patent number: 6156764
    Abstract: The present invention relates to morphine and diamorphine salts of anionic non-narcotic analgesics belonging to the type of substituted carboxylic acids, preferably the morphine and diamorphine salts of diclofenac (Formula 1); to processes for their production, the use of these salts in the treatment of diseases, as well as to pharmaceutical preparations comprising these salts.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: December 5, 2000
    Assignee: LTS Lohmann Therapie-Systeme GmbH
    Inventors: Bodo Asmussen, Walter Muller, Walter Riess
  • Patent number: 6114347
    Abstract: A pharmaceutical formulation for the prophylaxis and preliminary treatment of a poisoning caused by organophosphorus cholinesterase inhibitors is characterized in that it consists of an active substance combination of at least one parasympathomimetic and at least one parasympatholytic.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: September 5, 2000
    Assignees: LTS Lohmann Therapie-Systeme GmbH, Israel Institute for Biological Research
    Inventors: Thomas Hille, Walter Muller, Bodo Asmussen, Aharon Levy, Yacov Meshulam