Patents by Inventor Bodo Brunner

Bodo Brunner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RNA compositions and methods for inhibiting ANGPTL8
    Patent number: 12416004
    Abstract: The present disclosure relates to dsRNAs targeting ANGPTL8, methods of inhibiting ANGPTL8 gene expression, and methods of treating one or more conditions associated with ANGPTL8 gene expression.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: September 16, 2025
    Assignee: Sanofi
    Inventors: Bodo Brunner, Mike Helms, Armin Hofmeister, Kerstin Jahn-Hofmann, Christiane Metz-Weidmann, Sabine Scheidler, Pierrick Rival
  • RNA COMPOSITIONS AND METHODS FOR INHIBITING LIPOPROTEIN(A)
    Publication number: 20240035029
    Abstract: The present disclosure relates to dsRNAs targeting LPA mRNA and modulating Lp(a) plasma levels, and methods of treating one or more conditions associated with LPA gene expression.
    Type: Application
    Filed: October 15, 2021
    Publication date: February 1, 2024
    Inventors: Bodo BRUNNER, Bertrand FROTTIER, Etienne GUILLOT, Mike HELMS, Armin HOFMEISTER, Kerstin JAHN-HOFMANN, Sabine SCHEIDLER
  • NOVEL RNA COMPOSITIONS AND METHODS FOR INHIBITING ANGPTL3
    Publication number: 20230383294
    Abstract: The present disclosure relates to dsRNAs targeting ANGPTL3, methods of inhibiting ANGPTL3 gene expression, and methods of treating one or more conditions associated with ANGPTL3 gene expression.
    Type: Application
    Filed: October 15, 2021
    Publication date: November 30, 2023
    Inventors: Bodo BRUNNER, Mike HELMS, Armin HOFMEISTER, Kerstin JAHN-HOFMANN, Christiane METZ-WEIDMANN, Sabine SCHEIDLER, Pierrick RIVAL
  • OLIGONUCLEOTIDES CONTAINING NUCLEOTIDE ANALOGS
    Publication number: 20220372063
    Abstract: The present disclosure relates to double-stranded oligonucleotides, including double-stranded oligonucleotides such as siRNAs, comprising a sense strand oligonucleotide and an antisense strand oligonucleotide, and wherein the antisense strand oligonucleotide comprises one or more nucleotide analogs of formula (I-A) which are neither the 5?-overhang nucleotide nor the 3?-overhang nucleotide of the said antisense strand oligonucleotide, and wherein a nucleotide analog of formula (I-A) is as described in the disclosure. Oligonucleotides containing these analogs have superior biological activity, for example, increased in vitro stability and improved in vivo potency especially improved off-target profiles. The improved oligonucleotides are useful for silencing (e.g., reducing or eradicating) the expression of a target gene.
    Type: Application
    Filed: September 4, 2020
    Publication date: November 24, 2022
    Applicant: SANOFI
    Inventors: Bodo BRUNNER, Armin HOFMEISTER, Kerstin JAHN-HOFMANN
  • COMPOSITIONS AND METHODS FOR INHIBITING PCSK9
    Publication number: 20220290156
    Abstract: Provided herein, inter alia, are dsRNA compositions targeting PCSK9, methods of inhibiting PCSK9 gene expression, and methods of treating one or more diseases associated with PCSK9 gene expression.
    Type: Application
    Filed: August 27, 2020
    Publication date: September 15, 2022
    Applicant: SANOFI
    Inventors: Bodo BRUNNER, Kerstin JAHN-HOFMANN, Sabine SCHEIDLER, Pierrick RIVAL
  • NOVEL RNA COMPOSITIONS AND METHODS FOR INHIBITING ANGPTL8
    Publication number: 20220025367
    Abstract: The present disclosure relates to dsRNAs targeting ANGPTL8, methods of inhibiting ANGPTL8 gene expression, and methods of treating one or more conditions associated with ANGPTL8 gene expression.
    Type: Application
    Filed: November 22, 2019
    Publication date: January 27, 2022
    Applicant: Sanofi
    Inventors: Bodo BRUNNER, Mike HELMS, Armin HOFMEISTER, Kerstin JAHN-HOFMANN, Christiane METZ-WEIDMANN, Sabine SCHEIDLER, Pierrick RIVAL
  • Method of screening for a carnitine transporter agonist or antagonist and its uses
    Patent number: 7879563
    Abstract: The present invention is directed to a method of screening for a carnitine transporter agonist or for a carnitine transporter antagonist, to a kit for carrying out the method of screening for a carnitine transporter agonist or for a carnitine transporter antagonist, to a method for the manufacture of a medicament for the treatment of a carnitine transporter deficiency, to methods of diagnosis of a carnitine transporter deficiency, to the use of a protein for the manufacture of an antibody reacting with a carnitine transporter, to an oligonucleotide and to methods of treatment of a carnitine transporter deficiency.
    Type: Grant
    Filed: August 13, 2005
    Date of Patent: February 1, 2011
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Petra Arndt, Daniel Margerie, Bodo Brunner
  • Method of Screening for a Carnitine Transporter Agonist or Antagonist and it Uses
    Publication number: 20080132447
    Abstract: The present invention is directed to a method of screening for a carnitine transporter agonist or for a carnitine transporter antagonist, to a kit for carrying out the method of screening for a carnitine transporter agonist or for a carnitine transporter antagonist, to a method for the manufacture of a medicament for the treatment of a carnitine transporter deficiency, to methods of diagnosis of a carnitine transporter deficiency, to the use of a protein for the manufacture of an antibody reacting with a carnitine transporter, to an oligonucleotide and to methods of treatment of a carnitine transporter deficiency.
    Type: Application
    Filed: August 13, 2005
    Publication date: June 5, 2008
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Petra Arndt, Daniel Margerie, Bodo Brunner