Abstract: The invention relates to a heart valve prosthesis including a heart valve a main body for supporting the heart valve. The heart valve includes a terminating material selected from material and configured to at least partially close a paravalvular leak by controlled thrombus development.

Abstract: A balloon catheter has an outer shaft which surrounds a shaft lumen. The outer shaft has a proximal outer shaft portion connected to a distal outer shaft portion. An inner shaft is in a distal portion of the shaft lumen. A guide wire lumen is in the inner shaft. An opening at a proximal end portion of the inner shaft permits the guide wire to be guided out from the outer shaft. A metallic tube is in the shaft lumen. The proximal end portion of the inner shaft is engaged with the metallic tube. A separate, elongate and metallic stiffening element is in the shaft lumen, and is connected to the metallic tube and protrudes from the metallic tube into the distal portion of the shaft lumen and into the proximal portion of the shaft lumen to stiffen portions of the outer shaft.

Abstract: Packaging has an outer sleeve, which surrounds an interior space for receiving an object, such as a sterilized medical implant. A separate container is arranged in the interior space and surrounds an absorber in a gas-tight manner, such that a gas present in the interior space cannot pass to the absorber. The container is configured to be opened by the application of force when the outer sleeve is closed, such that a gas disposed in the interior space can pass to the absorber and can be absorbed thereby. In preferred embodiments, the absorber absorbs air with the reactive constituents O2 and/or H2O. Depending on the application, however, other gases can also be absorbed by the absorber. A method for packaging is also provided.

Abstract: A method for producing x-ray markers. During the process, a predetermined breaking point is severed in order to detach x-ray markers from part of a material layer. There is also described an x-ray marker, a medical implant, and a semifinished product.

Abstract: An implant having a preferably hollow cylindrical basic structure. A nonwoven fabric is disposed in and/or on the basic structure, the nonwoven fabric preferably comprising biocompatible thermoplastic polyurethane and/or a polymer selected from the group consisting of polylactic acid, polycaprolactone, and a copolymer thereof, and/or a polymer including polyphosphazene. At least in at least one section of the implant, preferably at the proximal and/or distal ends of the implant, fastening means are provided or the nonwoven fabric is treated such that, at least in the expanded state of the implant, the protrusion of nonwoven fabric sections from the implant is significantly reduced. Furthermore, a method for producing such an implant is provided.

Abstract: An inflatable and implantable balloon for treatment of degenerative disc disease, bones, lesions, spinal deformities and spinal motion segment instabilities. The balloon is comprised of adjustable and expandable volumes. Further disclosed are methods of forming, inserting, expanding, and implanting the multi-volume balloon for proper placement and stabilization of the spinal lesion or disease. Still further disclosed are kits for aligning and stabilizing elements of the spine.

Abstract: Packaging has an outer sleeve, which surrounds an interior space for receiving an object, such as a sterilized medical implant. A separate container is arranged in the interior space and surrounds an absorber in a gas-tight manner, such that a gas present in the interior space cannot pass to the absorber. The container is configured to be opened by the application of force when the outer sleeve is closed, such that a gas disposed in the interior space can pass to the absorber and can be absorbed thereby. In preferred embodiments, the absorber absorbs air with the reactive constituents O2 and/or H2O. Depending on the application, however, other gases can also be absorbed by the absorber. A method for packaging is also provided.

Abstract: An implant having a preferably hollow cylindrical basic structure. A nonwoven fabric is disposed in and/or on the basic structure, the nonwoven fabric preferably comprising biocompatible thermoplastic polyurethane and/or a polymer selected from the group consisting of polylactic acid; polycaprolactone, and a copolymer thereof, and/or a polymer including polyphosphazene. At least in at least one section of the implant, preferably at the proximal and/or distal ends of the implant, fastening means are provided or the nonwoven fabric is treated such that, at least in the expanded state of the implant, the protrusion of nonwoven fabric sections from the implant is significantly reduced. Furthermore, a method for producing such an implant is provided.

Abstract: An inflatable and implantable balloon for treatment of degenerative disc disease, bones, lesions, spinal deformities and spinal motion segment instabilities. The balloon is comprised of adjustable and expandable volumes. Further disclosed are methods of forming, inserting, expanding, and implanting the multi-volume balloon for proper placement and stabilization of the spinal lesion or disease. Still further disclosed are kits for aligning and stabilizing elements of the spine.

Abstract: An inflatable and implantable balloon for treatment of degenerative disc disease, bones, lesions, spinal deformities and spinal motion segment instabilities. The balloon is comprised of adjustable and expandable volumes. Further disclosed are methods of forming, inserting, expanding, and implanting the multi-volume balloon for proper placement and stabilization of the spinal lesion or disease. Still further disclosed are kits for aligning and stabilizing elements of the spine.

Abstract: A release device (150, 150a, 150b) for detaching a medical implant (105) from an insertion device (110), comprising a body (10, 10a, 10b) having a proximal end (12), which during use lies furthest from a distal end (120) of the insertion device (110), and a distal end (14), which during use faces the distal end (120) of the insertion device (110), wherein at least one first actuator (16, 18) is provided between the proximal and distal ends (12, 14), wherein the at least first actuator (16, 18) can be tilted about an axis substantially perpendicularly to at least one of the insertion elements (132, 134) so as to effect a targeted relative movement in the longitudinal direction between the first and second insertion elements (132, 134) of the insertion device (110).

Abstract: The invention relates to a drug-coated balloon catheter and to a method for producing the same. The balloon of the catheter includes (i) a main membrane, and (ii) an asymmetrical polymer membrane which is applied to an outside of the main membrane and into which at least one pharmaceutical active ingredient is introduced.

Abstract: The invention relates to a heart valve prosthesis including a heart valve a main body for supporting the heart valve. The heart valve includes a terminating material selected from material and configured to at least partially close a paravalvular leak by controlled thrombus development.

Abstract: A method for producing a balloon from a suitable blank is provided. The blank is introduced into an outer mold heated an first expanded to expand it against the inner wall of the outer mold. Pressure is reduced to relax the blank away from the inner wall. The three-dimensional volume of the mold is changed. Second expanding of the blank expands again against the inner wall of the changed volume of the outer mold. Balloons of the invention consist of a middle cylindrical region and two end regions delimiting the middle cylindrical region. With a pressure application of 6 bar, a ratio of the cross section in the middle region to the cross section in the end region is at least 2, and preferably greater than 3.

Abstract: An inflatable and implantable balloon for treatment of degenerative disc disease, bones, lesions, spinal deformities and spinal motion segment instabilities. The balloon is comprised of adjustable and expandable volumes. Further disclosed are methods of forming, inserting, expanding, and implanting the multi-volume balloon for proper placement and stabilization of the spinal lesion or disease. Still further disclosed are kits for aligning and stabilizing elements of the spine.

Abstract: An inflatable and implantable balloon for treatment of degenerative disc disease, bones, lesions, spinal deformities and spinal motion segment instabilities. The balloon is comprised of adjustable and expandable volumes. Further disclosed are methods of forming, inserting, expanding, and implanting the multi-volume balloon for proper placement and stabilization of the spinal lesion or disease. Still further disclosed are kits for aligning and stabilizing elements of the spine.

Abstract: The invention relates to a drug-coated balloon catheter and to a method for producing the same. The balloon of the catheter includes (i) a main membrane, and (ii) an asymmetrical polymer membrane which is applied to an outside of the main membrane and into which at least one pharmaceutical active ingredient is introduced.

Abstract: A balloon catheter includes a drug-coated balloon having an uncoated region free from drug coating, a displaceable protective sleeve covering the drug-coated balloon and an elongate catheter body that has a distal end and a proximal end. Another catheter has an uncoated region and/or an additional uncoated balloon is on the catheter body. The uncoated balloon or the additional uncoated balloon are mounted to be exposed first when the sleeve is displaced. This blocks blood flow while the drug coated balloon or balloon region is inflated to avoid or minimize release of drug into the blood stream away from the site of treatment.

Abstract: A catheter system with a distal functional element, such as a self-expanding stent, includes a feed tube. The distal end of the feed tube surrounds the functional element and a sliding element configured to strike against the proximal end of the functional element in order to push forward the functional element from the feed tube. The feed tube has a tip portion that is tapered in the delivered state and expands when the functional element is slid out. The tip portion is formed from a glued e-PTFE laminate that delaminates when stretched by the functional element.

Abstract: A method for manufacturing a balloon catheter forms a balloon from a mixture of at least one polymer and the least one crosslinking agent, and irradiating the formed balloon with UV light. The balloon catheter is particularly usable for introduction into a body vessel. A preferred balloon includes a mixture of at least one polymer and at least one crosslinking agent, polymer chains of the at least one polymer being connected by the at least one crosslinking agent. The at least one cross-linking agent is responsive to be activated by irradiation with UV light.