Patents by Inventor Bogdan Kazimierz Wilk

Bogdan Kazimierz Wilk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of progesterone receptor modulators
    Patent number: 8609712
    Abstract: Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: December 17, 2013
    Assignee: Wyeth LLC
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Anthony Francis Hadfield, Jean Louise Helom
  • PURIFICATION OF PROGESTERONE RECEPTOR MODULATORS
    Publication number: 20130012702
    Abstract: Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: Wyeth LLC
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Anthony Francis Hadfield, Jean Louise Helom
  • Purification of progesterone receptor modulators
    Patent number: 8309594
    Abstract: Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: November 13, 2012
    Assignee: Wyeth LLC
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Anthony Francis Hadfield, Jean Louise Helom
  • Thioamide derivatives as progesterone receptor modulators
    Patent number: 8168672
    Abstract: Thioamide compounds, and specifically, thioamide pyrrole compounds, and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators, in contraception, and in the treatment of progesterone-related maladies.
    Type: Grant
    Filed: February 2, 2010
    Date of Patent: May 1, 2012
    Assignee: Wyeth
    Inventor: Bogdan Kazimierz Wilk
  • Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same
    Patent number: 8129524
    Abstract: Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided: Z are the same or different and are H, optionally substituted C1 to C6 alkyl, or CORA; RA is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl; Q are the same or different and are H, OH, NH2, CN, halogen, optionally substituted C1 to C6 alkyl, optionally substituted C2 to C6 alkenyl, optionally substituted C1 to C6 alkynyl, optionally substituted C1 to C6 alkoxy, optionally substituted C1 to C6 aminoalkyl, or CORB; and RB is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: March 6, 2012
    Assignee: Wyeth LLC
    Inventor: Bogdan Kazimierz Wilk
  • Coupling process for generating reactive boron-containing derivatives of N-substituted pyrrole-2-carbonitriles to produce biaryls
    Patent number: 8129523
    Abstract: A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the use of these boron-containing compounds and derivatives thereof in coupling reactions to provide bi-aryl compounds.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: March 6, 2012
    Assignee: Wyeth LLC
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Jean Louise Helom
  • CYANOPYRROLE CONTAINING CYCLIC CARBAMATE AND THIOCARBAMATE BIARYLS AND METHODS FOR PREPARING THE SAME
    Publication number: 20120016118
    Abstract: Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided: Z are the same or different and are H, optionally substituted C1 to C6 alkyl, or CORA; RA is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl; Q are the same or different and are H, OH, NH2, CN, halogen, optionally substituted C1 to C6 alkyl, optionally substituted C2 to C6 alkenyl, optionally substituted C1 to C6 alkynyl, optionally substituted C1 to C6 alkoxy, optionally substituted C1 to C6 aminoalkyl, or CORB; and RB is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl.
    Type: Application
    Filed: July 11, 2011
    Publication date: January 19, 2012
    Applicant: Wyeth LLC
    Inventor: Bogdan Kazimierz Wilk
  • Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same
    Patent number: 8003784
    Abstract: Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided. Z are the same or different and are H, optionally substituted C1 to C6 alkyl, or CORA; RA is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl; Q are the same or different and are H, OH, NH2, CN, halogen, optionally substituted C1 to C6 alkyl, optionally substituted C2 to C6 alkenyl, optionally substituted C1 to C6 alkynyl, optionally substituted C1 to C6 alkoxy, optionally substituted C1 to C6 aminoalkyl, or CORB; and RB is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl.
    Type: Grant
    Filed: July 24, 2009
    Date of Patent: August 23, 2011
    Assignee: Wyeth LLC
    Inventor: Bogdan Kazimierz Wilk
  • Purified form of tanaproget
    Patent number: 7786297
    Abstract: Micronized tanaproget, purified tanaproget Form I, and micronized, purified tanaproget Form I are provided. Also provided are compositions containing one or more of the prepared tanaproget forms, methods of using one or more of the prepared tanaproget forms, and kits containing one or more of the prepared tanaproget forms.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: August 31, 2010
    Assignee: Wyeth LLC
    Inventors: Ramarao Chatlapalli, Arwinder Nagi, John Potoski, Jean Louise Helom, Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Vladimir Dragan
  • Thioamide Derivatives as Progesterone Receptor Modulators
    Publication number: 20100197645
    Abstract: Thioamide compounds, and specifically, thioamide pyrrole compounds, and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators, in contraception, and in the treatment of progesterone-related maladies.
    Type: Application
    Filed: February 2, 2010
    Publication date: August 5, 2010
    Applicant: Wyeth LLC
    Inventor: Bogdan Kazimierz Wilk
  • Process for the synthesis of progesterone receptor modulators
    Patent number: 7754895
    Abstract: Processes for preparing oxindoles, which can be utilized in the preparation of a variety of useful compounds, and methods for minimizing or preventing N-alkylation of amide containing compounds, including oxindoles, are provided.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: July 13, 2010
    Assignee: Wyeth LLC
    Inventors: Yanzhong Wu, Bogdan Kazimierz Wilk, Zhixian Ding, Xinxu Shi, Charles Chao Wu, Panolil Raveendranath, Haris Durutlic
  • Thioamide derivatives as progesterone receptor modulators
    Patent number: 7659265
    Abstract: Thioamide compounds, and specifically, thioamide pyrrole compounds, and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators, in contraception, and in the treatment of progesterone-related maladies.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: February 9, 2010
    Assignee: Wyeth
    Inventor: Bogdan Kazimierz Wilk
  • CYANOPYRROLE CONTAINING CYCLIC CARBAMATE AND THIOCARBAMATE BIARYLS AND METHODS FOR PREPARING THE SAME
    Publication number: 20090306371
    Abstract: Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided. Z are the same or different and are H, optionally substituted C1 to C6 alkyl, or CORA; RA is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl; Q are the same or different and are H, OH, NH2, CN, halogen, optionally substituted C1 to C6 alkyl, optionally substituted C2 to C6 alkenyl, optionally substituted C1 to C6 alkynyl, optionally substituted C1 to C6 alkoxy, optionally substituted C1 to C6 aminoalkyl, or CORB; and RB is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl.
    Type: Application
    Filed: July 24, 2009
    Publication date: December 10, 2009
    Applicant: Wyeth
    Inventor: Bogdan Kazimierz Wilk
  • Process for preparing 3,3-disubstituted oxindoles and thio-oxindoles
    Patent number: 7595338
    Abstract: Methods for preparing oxindole and thio-oxindole compounds are provided, which compounds are useful as precursors to useful pharmaceutical compounds. Specifically provided are methods for preparing 5-pyrrole-3,3-oxindole compounds and 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-1-methyl-1H-pyrrole-2-carbonitrile. Also provided are methods for preparing iminobenzo[b]thiophene and benzo[b]thiophenone compounds.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: September 29, 2009
    Assignee: Wyeth
    Inventor: Bogdan Kazimierz Wilk
  • Cyanopyrrole-containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same
    Patent number: 7582755
    Abstract: Methods for preparing cyclic carbamates and thiocarbamates containing cyanopyrrole moieties and of the formula are provided. Z are the same or different and are H, optionally substituted C1 to C6 alkyl, or CORA; RA is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl; Q are the same or different and are H, OH, NH2, CN, halogen, optionally substituted C1 to C6 alkyl, optionally substituted C2 to C6 alkenyl, optionally substituted C1 to C6 alkynyl, optionally substituted C1 to C6 alkoxy, optionally substituted C1 to C6 aminoalkyl, or CORB; and RB is H, optionally substituted C1 to C6 alkyl, optionally substituted C1 to C6 alkoxy, or optionally substituted C1 to C6 aminoalkyl.
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: September 1, 2009
    Assignee: Wyeth
    Inventor: Bogdan Kazimierz Wilk
  • PURIFICATION OF PROGESTERONE RECEPTOR MODULATORS
    Publication number: 20090143577
    Abstract: Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
    Type: Application
    Filed: February 12, 2009
    Publication date: June 4, 2009
    Applicant: Wyeth
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Anthony Francis Hadfield, Jean Louise Helom
  • THIOAMIDE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS
    Publication number: 20090143345
    Abstract: Thioamide compounds, and specifically, thioamide pyrrole compounds, and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators, in contraception, and in the treatment of progesterone-related maladies.
    Type: Application
    Filed: February 12, 2009
    Publication date: June 4, 2009
    Applicant: Wyeth
    Inventor: Bogdan Kazimierz Wilk
  • Purification of progesterone receptor modulators
    Patent number: 7514466
    Abstract: Methods for purifying a compound of formula I are provided, wherein A, B X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: April 7, 2009
    Assignee: Wyeth
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Anthony Francis Hadfield, Jean Louise Helom
  • Thioamide derivatives as progesterone receptor modulators
    Patent number: 7511071
    Abstract: Thioamide compounds, and specifically, thioamide pyrrole compounds, and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators, in contraception, and in the treatment of progesterone-related maladies.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: March 31, 2009
    Assignee: Wyeth
    Inventor: Bogdan Kazimierz Wilk
  • COUPLING PROCESS FOR GENERATING REACTIVE BORON-CONTAINING DERIVATIVES OF N-SUBSTITUTED PYRROLE-2-CARBONITRILES TO PRODUCE BIARYLS
    Publication number: 20090054663
    Abstract: A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the use of these boron-containing compounds and derivatives thereof in coupling reactions to provide bi-aryl compounds.
    Type: Application
    Filed: September 26, 2008
    Publication date: February 26, 2009
    Applicant: Wyeth
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Jean Louise Helom