Abstract: Methods and systems for deconvoluting tumor ecosystems for personalized cancer therapy are disclosed. Generally, human cancers exhibit large variation in behavior between and within patients, which is in large part related to cellular composition. Identifying cell types can identify specific types of tumors and/or cancers present in an individual. Further embodiments generally describe identifying therapies from clinical trials to which the tumor or cancer ecotypes respond, thus providing personalized therapies based on the identified cancer or tumor type.