Patents by Inventor Bohan Jin

Bohan Jin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR MODULATING NLRP3 OR NLRP1 EXPRESSION
    Publication number: 20240409931
    Abstract: Described herein are compositions of an antisense oligonucleotide capable of binding to NACHT, LRR and PYD domains-containing protein 3 (NLRP3) or NLRP1 mRNA for modulating gene expressions. Also described herein are methods for using the compositions described herein for modulating gene expressions or for treating inflammasome-associate disease.
    Type: Application
    Filed: September 1, 2022
    Publication date: December 12, 2024
    Inventors: Lishan CHEN, Bohan JIN, Timothy Preston WONG
  • COMPOSITIONS AND METHODS FOR MODULATING KRAS EXPRESSION
    Publication number: 20240392293
    Abstract: Described herein are compositions for modulating gene expressions. Also described herein are methods for using the compositions described herein for modulating gene expressions.
    Type: Application
    Filed: September 1, 2022
    Publication date: November 28, 2024
    Inventors: Lishan CHEN, Bohan JIN
  • THYROID HORMONE RECEPTOR AGONISTS AND USES THEREOF
    Publication number: 20240360106
    Abstract: Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with thyroid hormone receptor activity. The methods and compositions disclosed herein include the use of at least one thyroid hormone receptor agonist.
    Type: Application
    Filed: March 14, 2024
    Publication date: October 31, 2024
    Inventors: Bohan JIN, Qing DONG, Gene HUNG
  • Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors
    Patent number: 12060343
    Abstract: Described herein are compounds, for example, 1,2,4-triazole-substituted N-heteroaryl amines, that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.
    Type: Grant
    Filed: April 5, 2022
    Date of Patent: August 13, 2024
    Assignee: Alumis Inc.
    Inventors: Bohan Jin, Qing Dong, Gene Hung, Stephen W. Kaldor
  • Substituted pyridazines as TYK2 inhibitors
    Patent number: 12006306
    Abstract: Described herein are compounds, for example, substituted pyridazines, that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.
    Type: Grant
    Filed: April 28, 2021
    Date of Patent: June 11, 2024
    Assignee: Alumis Inc.
    Inventors: Bohan Jin, Qing Dong, Gene Hung, Stephen W. Kaldor
  • COMPOSITIONS AND METHODS FOR MODULATING SOS GENE EXPRESSIONS
    Publication number: 20240182894
    Abstract: Described herein are compositions for modulating gene expressions. Also described herein are methods for using the compositions described herein for modulating gene expressions.
    Type: Application
    Filed: April 22, 2022
    Publication date: June 6, 2024
    Inventors: Lishan CHEN, Bohan JIN
  • Thyroid hormone receptor agonists and uses thereof
    Patent number: 11964964
    Abstract: Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with thyroid hormone receptor activity. The methods and compositions disclosed herein include the use of at least one thyroid hormone receptor agonist.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: April 23, 2024
    Assignee: XIZANG HAISCO PHARMACEUTICAL CO., LTD.
    Inventors: Bohan Jin, Gene Hung, Qing Dong
  • SUBSTITUTED 1,2,4-TRIAZOLES AS INTERMEDIATES IN THE SYNTHESIS OF TYK2 INHIBITORS
    Publication number: 20230391751
    Abstract: Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.
    Type: Application
    Filed: June 15, 2023
    Publication date: December 7, 2023
    Inventors: Bohan Jin, Qing Dong, Gene Hung, Stephen W. Kaldor
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20230357273
    Abstract: Described herein are compounds of Formula (I) that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.
    Type: Application
    Filed: September 16, 2021
    Publication date: November 9, 2023
    Inventors: Bohan JIN, Qing DONG, Gene HUNG
  • Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors
    Patent number: 11731956
    Abstract: Described herein are compounds, for example, 1,2,4-triazole-substituted N-heteroaryl amines, that are useful in treating a TYK2-mediated disorder. In some embodiments, the TY-K2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.
    Type: Grant
    Filed: August 19, 2022
    Date of Patent: August 22, 2023
    Assignee: Alumis Inc.
    Inventors: Bohan Jin, Qing Dong, Gene Hung, Stephen W. Kaldor
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20230021554
    Abstract: Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.
    Type: Application
    Filed: August 19, 2022
    Publication date: January 26, 2023
    Inventors: Bohan Jin, Qing Dong, Gene Hung, Stephen W. Kaldor
  • SUBSTITUTED PYRIDINES AS TYK2 INHIBITORS
    Publication number: 20230023761
    Abstract: Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.
    Type: Application
    Filed: April 28, 2021
    Publication date: January 26, 2023
    Inventors: Bohan JIN, Qing DONG, Gene HUNG, Stephen W. KALDOR
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20220235035
    Abstract: Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.
    Type: Application
    Filed: April 5, 2022
    Publication date: July 28, 2022
    Inventors: Bohan Jin, Qing Dong, Gene Hung, Stephen W. Kaldor
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20220177486
    Abstract: Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.
    Type: Application
    Filed: March 10, 2020
    Publication date: June 9, 2022
    Inventors: Bohan JIN, Qing DONG, Gene HUNG
  • TERPINOID DERIVATIVES AND USES THEREOF
    Publication number: 20220017566
    Abstract: Described herein are terpinoid derivatives as NRF2 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of inflammatory diseases.
    Type: Application
    Filed: September 23, 2019
    Publication date: January 20, 2022
    Inventors: Bohan JIN, Qing DONG, Gene HUNG, Stephen W. KALDOR
  • Substituted pyridines as TYK2 inhibitors
    Patent number: 11053219
    Abstract: Described herein are pyridine compounds of Formula (XIII) that are useful in treating a TYK2-mediated disorder.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: July 6, 2021
    Assignee: Esker Therapeutics, Inc.
    Inventors: Bohan Jin, Qing Dong, Gene Hung, Stephen W. Kaldor
  • Autotaxin inhibitors and uses thereof
    Patent number: 11040972
    Abstract: Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with autotaxin activity. The methods and compositions disclosed herein include the use of at least one autotaxin inhibitor compound.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: June 22, 2021
    Assignee: SICHUAN HAISCO PHARMACEUTICAL CO., LTD.
    Inventors: Bohan Jin, Qing Dong, Gene Hung, Yao Li
  • Apoptosis signal-regulating kinase inhibitors and uses thereof
    Patent number: 11034671
    Abstract: Described herein are ASK1 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of blood disease, autoimmune disorders, pulmonary disorders, hypertension, inflammatory diseases, fibrotic diseases, diabetes, diabetic nephropathy, renal diseases, respiratory diseases, cardiovascular diseases, acute lung injuries, acute or chronic liver diseases, and neurodegenerative diseases.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: June 15, 2021
    Assignee: SICHUAN HAISCO PHARMACEUTICAL CO., LTD.
    Inventors: Bohan Jin, Qing Dong, Gene Hung
  • THYROID HORMONE RECEPTOR AGONISTS AND USES THEREOF
    Publication number: 20210115022
    Abstract: Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with thyroid hormone receptor activity. The methods and compositions disclosed herein include the use of at least one thyroid hormone receptor agonist.
    Type: Application
    Filed: May 28, 2019
    Publication date: April 22, 2021
    Inventors: Bohan JIN, Qing DONG, Gene HUNG
  • TYK2 INHIBITORS AND USES THEREOF
    Publication number: 20200354338
    Abstract: Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.
    Type: Application
    Filed: July 24, 2020
    Publication date: November 12, 2020
    Inventors: Bohan JIN, Qing DONG, Gene HUNG, Stephen W. Kaldor