Abstract: Proxy-based scaling may be performed for databases. A proxy may be implemented for a database that can establish a connection between the proxy and a database engine to perform a database queries received from a client at the proxy. A scaling event may be detected for the database responsive to which the proxy may establish a connection with a new database engine which may, in some embodiments, have different capabilities or resources that address the features or criteria that triggered the scaling event. Session state may be copied from the database engine to the new database engine so that the new database engine may be able to provide access to the database on behalf of requests received from the client through the proxy.

Abstract: The present disclosure describes the grafting of epitope residues from human PCSK9 to non-human PCSK9 or PCSK9 structural homologs and elimination of 9-mers oligopeptides that are found in human protein to reduce self-targeting response. Anti-genicity of the epitope-scaffold constructs was demonstrated toward anti-human PCSK9 antibodies. similar to wild type human PCSK9. It was shown that disclosed PCSK9 immunogens could significantly reduce LDL and cholesterol levels in immunized mice.

Abstract: Optimistic concurrency may be implemented for multiple writers to a database. Writes to a database from different writers may succeed unless a conflict is detected at the data store for the database. For detected conflicts, a request to resolve the conflict between writes may be submitted to a primary writer, which may determine and provide a resolution of the conflict to the conflicting writers. The data store may then be updated to commit the selected write identified by the resolution of the conflict.

Abstract: A service provider network implements seamless scaling via proxy replay of session state. Upon a trigger, such as a determination to scale a server, a scaled server may be spun up and an identifier of the scaled server provided to a first (existing) server. The first server sends the identification of the second server, and session state information for each of the connections between the first server and the request router, to the request router. For each of the connections, the request router establishes a new connection between the request router and the second (scaled) server, and replays the session state information for the connection to the second server. The request router then routes traffic between each existing client connection (e.g., the same existing client connection which carried traffic delivered to the first server) and the corresponding new connection to the second server.

Abstract: Proxy-based scaling may be performed for databases. A proxy may be implemented for a database that can establish a connection between the proxy and a database engine to perform a database queries received from a client at the proxy. A scaling event may be detected for the database responsive to which the proxy may establish a connection with a new database engine which may, in some embodiments, have different capabilities or resources that address the features or criteria that triggered the scaling event. Session state may be copied from the database engine to the new database engine so that the new database engine may be able to provide access to the database on behalf of requests received from the client through the proxy.

Abstract: Proxy-based scaling may be performed for databases. A proxy may be implemented for a database that can establish a connection between the proxy and a database engine to perform a database queries received from a client at the proxy. A scaling event may be detected for the database responsive to which the proxy may establish a connection with a new database engine which may, in some embodiments, have different capabilities or resources that address the features or criteria that triggered the scaling event. Session state may be copied from the database engine to the new database engine so that the new database engine may be able to provide access to the database on behalf of requests received from the client through the proxy.

Abstract: A system for updating a database instance with a patch or new binary image. A database instance includes a database engine and a client-side storage layer driver to manage database state information and volume geometry state information associated with client process connections to a volume of a storage layer of a database system during the patching process. The database engine and the client-side storage service driver save database state information and volume geometry state information, execute the new binary image, and restore the updated database engine with the database state information and volume geometry state information. The new binary image may be executed using a fork/exec model, wherein file descriptors used to identify sockets used in existing client connections are preserved, enabling restoration of the client connections without interruption or downtime.