Abstract: Systems, methods, devices, and apparatuses generate a fully integrated broadband high power frequency combs, based on a multimode gain chip. Embodiments can generate a frequency comb spanning over ˜150 nm and include self-injection locking of a multimode chip-based gain, which can allow access to high pump power while maintaining single mode operation. The integrated frequency comb systems and methods can comprise a multimode gain chip, a ring resonator in optical communication with a waveguide and, and an integrated heater in thermal communication with the ring resonator. Embodiments can be configured to receive multimode gain input and effect a single-mode ring feedback to determine a target mode. A temperature of the ring resonator can be optionally adjusted to modulate the ring feedback, and the ring feedback can be applied to the multimode gain input to generate an output frequency comb that includes the target mode.

Abstract: Disclosed herein is a paroxetine cholate or cholic acid derivative salt and a composition comprising paroxetine and cholic acid or a derivative thereof. Further disclosed is a pharmaceutical composition comprising the paroxetine salt or the composition. The pharmaceutical composition can be formulated into an oral preparation for swallowing without water as an orally disintegrating tablet for paroxetine.

Abstract: The present invention relates to a thiazolidinedione derivative, represented in formula (1) below, pharmaceutically acceptable salts thereof, and/or pharmaceutically acceptable solvates thereof. Further, the present invention provides a pharmaceutical composition comprising the compound represented in formula (1) below, wherein: X represents a carbon or nitrogen atom, Y represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen, or an aryl group, Z represents an oxygen, nitrogen, or sulfur atom, and R1 and R2 each represent a hydrogen atom; or R1 and R2 together form a bond.

Abstract: The present invention relates to a thiazolidinedione derivative, represented in formula (1) below, pharmaceutically acceptable salts thereof, and/or pharmaceutically acceptable solvates thereof.