Patents by Inventor Bolei QU

Bolei QU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRROLO BENZODIAZEPINE DERIVATIVE, AND CONJUGATE, PREPARATION METHOD AND USE THEREOF
    Publication number: 20250000989
    Abstract: The present disclosure relates to a pyrrolo benzodiazepine derivative and a conjugate, preparation method and use thereof. In particular, the present disclosure relates to a compound of formula (DL) and a antibody-drug conjugate thereof, a pharmaceutical composition containing same, and a use thereof in the preparation of a medicament for the treatment of cancer. The definitions of groups in the general formula (DL) are as defined in the description.
    Type: Application
    Filed: September 30, 2022
    Publication date: January 2, 2025
    Inventors: Jianyan XU, Xiaofeng CAI, Bolei QU, Ying ZHANG, Xiaoxi CHEN, Feng HE, Weikang TAO, Lingjian ZHU, Min HONG, Jian HUANG, Yanbing LI, Xiaolang XU, Zhipeng HU, Zhouyang XUE, Lingfeng YOU
  • LIGAND-DRUG CONJUGATE OF EXATECAN ANALOGUE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
    Publication number: 20210353764
    Abstract: The present invention relates to a ligand-drug conjugate of an exatecan analogue, a preparation method therefor and an application thereof. Specifically, the present invention provides a ligand-drug conjugate having a structure shown in formula (-D), a preparation method therefor, a pharmaceutical composition containing same, and use thereof in preparation of drugs for treating cancers by means of receptor regulation. The definition of each substituent in formula (-D) is the same as that in the description.
    Type: Application
    Filed: September 25, 2019
    Publication date: November 18, 2021
    Inventors: Jianyan XU, Ying ZHANG, Xiaofeng CAI, Bolei QU, Jindong LIANG, Lianshan ZHANG, Feng HE, Weikang TAO
  • Toxin and method for preparing intermediate thereof
    Patent number: 10513510
    Abstract: The present invention relates to a new toxin and a method for preparing an intermediate thereof. In particular, the present invention relates to a new toxin and a method for preparating intermediates of Formula (III) and Formula (IV) thereof, and a preparation method for synthesizing what is shown in general formula (I). The method comprises subjecting a chiral compound shown in general formula (III) to a series of protecting group additions, protecting group removal and amidation so as to obtain a compound as shown in general formula (I). The present method has the advantages of mild reaction conditions, simple operation, high optical purity and high synthetic yield, and thus is suitable for large-scale production.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: December 24, 2019
    Assignees: Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
    Inventors: Jianyan Xu, Ying Zhang, Bolei Qu, Guiyang Jiang
  • TOXIN AND METHOD FOR PREPARING INTERMEDIATE THEREOF
    Publication number: 20190055223
    Abstract: The present invention relates to a new toxin and a method for preparing an intermediate thereof. In particular, the present invention relates to a new toxin and a method for preparating intermediates of Formula (III) and Formula (IV) thereof, and a preparation method for synthesizing what is shown in general formula (I). The method comprises subjecting a chiral compound shown in general formula (III) to a series of protecting group additions, protecting group removal and amidation so as to obtain a compound as shown in general formula (I). The present method has the advantages of mild reaction conditions, simple operation, high optical purity and high synthetic yield, and thus is suitable for large-scale production.
    Type: Application
    Filed: February 24, 2017
    Publication date: February 21, 2019
    Inventors: Jianyan XU, Ying ZHANG, Bolei QU, Guiyang JIANG
  • LIGAND-CYTOTOXIC DRUG CONJUGATE, PREPARATION METHOD THEREOF, AND USE THEREOF
    Publication number: 20180177890
    Abstract: Provide are ligand-cytotoxic drug conjugates with a general formula of PC-L-Dr, a preparation method thereof, and uses of the ligand-cytotoxic drug conjugate and pharmaceutical compositions containing the same in preparing drugs for treating cancers by means of receptor regulation.
    Type: Application
    Filed: January 26, 2016
    Publication date: June 28, 2018
    Inventors: Jianyan XU, Ying ZHANG, Bolei QU, Fuyao ZHANG, Xiuzhao YU, Jindong LIANG, Guiyang JIANG, Lianshan ZHANG, Ang LI, Yali WANG