Patents by Inventor Boliang Cao (Brian)

Boliang Cao (Brian) has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monoclonal antibody which binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues and related methods
    Patent number: 7892770
    Abstract: In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a) a monoclonal antibody named Met4, which antibody is specific for Met, and (b) a hybridoma cell line that produces Met4. The Met4 antibody is particularly useful for detecting Met in formalin-fixed tissue. Methods of using the Met4 antibody for detection, diagnosis, prognosis, and evaluating therapeutic efficacy are provided.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: February 22, 2011
    Assignees: Van Andel Research Institute, Fred Hutchinson Cancer Research Center
    Inventors: Boliang Cao (Brian), George F. Vande Woude, Beatrice S. Knudsen
  • Monoclonal Antibody Which Binds Met In Formalin-Fixed and Paraffin-Embedded Tissues and Related Methods
    Publication number: 20090053737
    Abstract: In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a) a monoclonal antibody named Met4, which antibody is specific for Met, and (b) a hybridoma cell line that produces Met4. The Met4 antibody is particularly useful for detecting Met in formalin-fixed tissue. Methods of using the Met4 antibody for detection, diagnosis, prognosis, and evaluating therapeutic efficacy are provided.
    Type: Application
    Filed: August 24, 2007
    Publication date: February 26, 2009
    Inventors: Boliang Cao (Brian), George F. Vande Woude, Beatrice S. Knudsen