Patents by Inventor Bolin Liu

Bolin Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Insect-resistant herbicide-tolerant corn transformation event
    Patent number: 11479790
    Abstract: An insect-resistant herbicide-tolerant corn transformation event, and a related creation method, a detection method, and application thereof are provided herein. Using the corn inbred line Xiang 249 as a receptor, by means of agrobacterium-mediated genetic transformation, obtaining a corn plant with an exogenous gene insert inserted at a specific genomic locus, the exogenous gene insert comprising the following three genes: an insect-resistant gene, a glufosinate resistant gene, and a glyphosate resistant gene. In the obtained transformation event, the inserted exogenous genes are positioned at a non-functional locus of the corn genome, and do not affect the expression of the other genes of the receptor plant, such that the transgenic corn plant maintains good agronomic traits whilst acquiring insect resistance and herbicide tolerance.
    Type: Grant
    Filed: February 2, 2019
    Date of Patent: October 25, 2022
    Assignee: CHINA NATIONAL SEED GROUP CORPORATION, LTD.
    Inventors: Bolin Liu, Qiuming She, Chao Tan, Jieting Xu, Xuxia Wang, Peixiuzi Tian, Dongming Nie, Yu Han, Chonglie Ma, Wanggen Zhang
  • INSECT-RESISTANT HERBICIDE-TOLERANT CORN TRANSFORMATION EVENT
    Publication number: 20210054402
    Abstract: An insect-resistant herbicide-tolerant corn transformation event, and a related creation method, a detection method, and application thereof are provided herein. Using the corn inbred line Xiang 249 as a receptor, by means of agrobacterium-mediated genetic transformation, obtaining a corn plant with an exogenous gene insert inserted at a specific genomic locus, the exogenous gene insert comprising the following three genes: an insect-resistant gene, a glufosinate resistant gene, and a glyphosate resistant gene. In the obtained transformation event, the inserted exogenous genes are positioned at a non-functional locus of the corn genome, and do not affect the expression of the other genes of the receptor plant, such that the transgenic corn plant maintains good agronomic traits whilst acquiring insect resistance and herbicide tolerance.
    Type: Application
    Filed: February 2, 2019
    Publication date: February 25, 2021
    Applicant: CHINA NATIONAL SEED GROUP CORPORATION, LTD.
    Inventors: BOLIN LIU, QIUMING SHE, CHAO TAN, JIETING XU, XUXIA WANG, PEIXIUZI TIAN, DONGMING NIE, YU HAN, CHONGLIE MA, WANGGEN ZHANG
  • Gene for encoding crystal proteins, and use thereof
    Patent number: 10626411
    Abstract: The present disclosure relates to a gene sequence Cry1Ab/Cry1AcZM, an expression cassette containing the gene, an expression vector, a host cell and the use thereof in plant breeding. The protein encoded by an insect-resistant gene according to the disclosure can be expressed in a monocotyledonous plant and further used for culturing an insect-resistant transgenic monocotyledonous plant harboring transgenes Cry1Ab/Cry1AcZM. Bioassay tests prove that the modified and synthesized gene sequence Cry1Ab/Cry1AcZM and the expression product of the constructed vector according to the disclosure have a killing effect on lepidopteran pests.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: April 21, 2020
    Assignee: China National Seed Group Corporation, Ltd.
    Inventors: Bolin Liu, Chao Tan, Qianqian Yang, Jieting Xu, Qin Wen, Long Qiu, Chonglie Ma, Wanggen Zhang
  • GENE FOR ENCODING BACILLUS THURINGIENSIS CRYSTAL PROTEINS, AND USE THEREOF
    Publication number: 20180362998
    Abstract: The present disclosure relates to a gene sequence Cry1Ab/Cry1AcZM, an expression cassette containing the gene, an expression vector, a host cell and the use thereof in plant breeding. The protein encoded by an insect-resistant gene according to the disclosure can be expressed in a monocotyledonous plant and further used for culturing an insect-resistant transgenic monocotyledonous plant harboring transgenes Cry1Ab/Cry1AcZM. Bioassay tests prove that the modified and synthesized gene sequence Cry1Ab/Cry1AcZM and the expression product of the constructed vector according to the disclosure have a killing effect on lepidopteran pests.
    Type: Application
    Filed: July 22, 2016
    Publication date: December 20, 2018
    Applicant: China National Seed Group Corporation, Ltd.
    Inventors: Bolin LIU, Chao TAN, Qianqian YANG, Jieting XU, Qin WEN, Long QIU, Chonglie MA, Wanggen ZHANG
  • Markers For Assessing the Susceptibility of Cancer to Survivin-Targeting miRNA Treatment
    Publication number: 20140051744
    Abstract: The present invention relates to the use of miRNA treatment of survivin-positive cancer cells to increase sensitivity of cells to chemotherapy.
    Type: Application
    Filed: August 14, 2013
    Publication date: February 20, 2014
    Applicant: The Regents of the University of Colorado, A Body Corporate
    Inventors: Bolin LIU, Shuiliang WANG
  • Administration of an Inhibitor of HDAC, an Inhibitor of HER-2, and a Selective Estrogen Receptor Modulator
    Publication number: 20110182888
    Abstract: Methods of treating patients with an HDAC inhibitor and a HER-2 inhibitor are provided herein. In some embodiments, a SERM is also administered.
    Type: Application
    Filed: April 7, 2009
    Publication date: July 28, 2011
    Inventors: Peter Ordentlich, Bob Goodenow, Bolin Liu, Xiaoping Huang
  • Lysine rich protein from winged bean
    Patent number: 6184437
    Abstract: A lysine-rich protein gene has been cloned from winged bean, Psophocarpus tetragonolobus, and its DNA sequence and deduced protein sequence are provided. Methods for transforming plant cells are provided that mature into plants having elevated levels of lysine in their seeds.
    Type: Grant
    Filed: November 5, 1997
    Date of Patent: February 6, 2001
    Assignees: Beijing Vegetable Research Center, Institute of Botany, Academia Sinica, University of Hawaii
    Inventors: Samuel S. M. Sun, Liwen Xiong, Yuxiang Jing, Bolin Liu