Abstract: Disclosed is a pharmaceutical composition for the prevention or treatment of ischemic heart diseases, comprising as an active ingredient an inhibitor which acts to restrain mononuclear phagocyte system cells from synthesizing or releasing AGE-albumin, which induces the apoptosis of cardiomyocytes upon the onset of the ischemic heart disease. Also, a method is provided for screening an inhibitor against the AGE-albumin synthesis or release of mononuclear phagocyte system cells. Inhibitory or suppressive of AGE-albumin-induced cell death, the pharmaceutical composition comprising as an active ingredient an inhibitor against the AGE-albumin synthesis or release of mononuclear phagocyte system cells can be applied to the prevention or treatment of a wide spectrum of ischemic heart diseases including myocardial infarction.

Abstract: The present invention relates to a method for diagnosing glioma by comparing the protein location of an individual to be diagnosed with the normal control nerve cells. More particularly, the present invention relates to a method for diagnosing glioma including determining that an individual has glioma when the expression level of GFR?4 in the endoplasmic reticulum is higher than that in the plasma membrane, and a method for screening a therapeutic agent for glioma. In the diagnostic method of the present invention, the protein expression levels in particular subcellular locations are compared, thereby accurately diagnosing glioma, diagnosing progression of glioma, and predicting prognosis after glioma surgery.

Abstract: A fixing device including a lubricant supply unit is provided. The lubricant supply unit supplies a lubricant between a fixing belt and a nip forming member and includes a lubricant storage member and an impregnation member. The lubricant storage member stores the lubricant, and the impregnation member impregnates the lubricant discharged from the lubricant storage member and supplies the lubricant to an inner surface of the fixing belt. The lubricant stored in the lubricant storage member includes base oil and a thickener, and a weight of the thickener is equal to or less than 20% with respect to a weight of the lubricant.

Abstract: Disclosed is a pharmaceutical composition for the prevention or treatment of ischemic heart diseases, comprising as an active ingredient an inhibitor which acts to restrain mononuclear phagocyte system cells from synthesizing or releasing AGE-albumin, which induces the apoptosis of cardiomyocytes upon the onset of the ischemic heart disease. Also, a method is provided for screening an inhibitor against the AGE-albumin synthesis or release of mononuclear phagocyte system cells. Inhibitory or suppressive of AGE-albumin-induced cell death, the pharmaceutical composition comprising as an active ingredient an inhibitor against the AGE-albumin synthesis or release of mononuclear phagocyte system cells can be applied to the prevention or treatment of a wide spectrum of ischemic heart diseases including myocardial infarction.

Abstract: A fusing apparatus to fuse a toner image transferred to a printing medium by applying heat and pressure. The fusing apparatus includes a separation member that is rotatably mounted on a rotation axis to separate the printing medium from one of a heating roller and a pressing roller. The separation member includes a hollow portion into which the rotation axis is inserted, and a separation portion that contacts an outer circumference of the heating roller. The separation member is installed so as to be pitched around the rotation axis and a pitching axis having an inclination angle within a range of ±10° with respect to a line that connects a contact point between the separation portion and the outer circumference of the roller from which the printing medium is to be separated and a center of the roller from which the printing medium is to be separated.

Abstract: An image forming apparatus includes a heat roller heated to a preset temperature; a pressure roller for having conductivity and forming a nip by pressure-contacting with the heat roller; a power supply unit to apply a bias voltage to the pressure roller; and a controller to, when a printing paper enters the nip, control the power supply unit to apply the bias voltage to the pressure roller. When a time interval is longer than a preset time, the controller can control the power supply unit not to apply the bias voltage when the printing paper is not placed in the nip, and when the time interval is shorter than the preset time, the controller can control the power supply unit to apply the bias voltage when the printing paper is not placed in the nip.

Abstract: The present invention relates to a method for diagnosing glioma by comparing the protein location of an individual to be diagnosed with the normal control nerve cells. More particularly, the present invention relates to a method for diagnosing glioma including determining that an individual has glioma when the expression level of GFR?4 in the endoplasmic reticulum is higher than that in the plasma membrane, and a method for screening a therapeutic agent for glioma. In the diagnostic method of the present invention, the protein expression levels in particular subcellular locations are compared, thereby accurately diagnosing glioma, diagnosing progression of glioma, and predicting prognosis after glioma surgery.

Abstract: The present invention relates to a method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of AGE-albumin in cells of the mononuclear phagocyte system, to an AGE-albumin synthesis inhibitor, and to a pharmaceutical composition comprising the AGE-albumin synthesis inhibitor for preventing or treating degenerative disease and autoimmune disease. The AGE-albumin of the present invention is synthesized and secreted in human microglia or human macrophages in an Alzheimer's model, stroke model, Parkinson's disease model and rheumatoid arthritis model. The AGE-albumin synthesis and secretion are caused by oxidative stress. The expression of RAGE increases in first-order human neurons or cartilage cells to which AGE-albumin is administered, whereupon a MAPK signaling pathway is activated and the expression of Bax increases to induce an increase in calcium in mitochondria, thus finally inducing cell death.

Abstract: A fusing apparatus to fuse a toner image transferred to a printing medium by applying heat and pressure. The fusing apparatus includes a separation member that is rotatably mounted on a rotation axis to separate the printing medium from one of a heating roller and a pressing roller. The separation member includes a hollow portion into which the rotation axis is inserted, and a separation portion that contacts an outer circumference of the heating roller. The separation member is installed so as to be pitched around the rotation axis and a pitching axis having an inclination angle within a range of ±10° with respect to a line that connects a contact point between the separation portion and the outer circumference of the roller from which the printing medium is to be separated and a center of the roller from which the printing medium is to be separated.

Abstract: An image forming apparatus includes a heat roller heated to a preset temperature; a pressure roller for having conductivity and forming a nip by pressure-contacting with the heat roller; a power supply unit to apply a bias voltage to the pressure roller; and a controller to, when a printing paper enters the nip, control the power supply unit to apply the bias voltage to the pressure roller. When a time interval is longer than a preset time, the controller can control the power supply unit not to apply the bias voltage when the printing paper is not placed in the nip, and when the time interval is shorter than the preset time, the controller can control the power supply unit to apply the bias voltage when the printing paper is not placed in the nip.

Abstract: An image forming apparatus and a fusing unit thereof. The image forming apparatus includes a photosensitive body on which to form an electrostatic latent image, an exposure device to irradiate light to the photosensitive body to form the electrostatic latent image, a developer adhering device to adhere a developer to the photosensitive body on which the electrostatic latent image has been formed to form a visible image, a transfer device to transfer the visible image formed on the photosensitive body onto a printing medium, and a fusing unit to fuse the visible image transferred onto the printing medium to the printing medium.

Abstract: Disclosed is a waste developer collecting unit of an image forming apparatus that can include a casing configured to store waste developer, an auger rotatably disposed inside the casing and configured to move the waste developer around inside the casing, a detection unit configured to detect a load applied to the auger, the applied load being in corresponding relationship with an amount of waste developer stored in the casing, and a control unit configured to determine whether the amount of waste developer in the casing has reached a reference amount based on the detection result produced by the detection unit.

Abstract: An image forming apparatus has an image forming part forming an image on paper, and a housing accommodating the image forming part and having a paper stack part stacking paper discharged from the image forming part, and the image forming apparatus includes an accommodating part formed in an edge of the paper stack part and extending in a paper discharge direction; a base plate mounted in the accommodating part to be slidable in the paper discharge direction and a reverse direction opposite to the paper discharge direction; and a stopper hinge-coupled to the base plate to be tiltable among a stand up position where the stopper blocks paper discharged from the image forming part, a rear folding position where the stopper is folded onto the base plate and is at least partially accommodated in the paper stack part, and a front folding position where the stopper is folded in the paper discharge direction.

Abstract: A rollers separating unit which controls a distance between a heating roller and a pressurizing roller of a fixing unit by an opening/closing of a side cover. The rollers separating unit includes an elastic support member rotatably hinge-coupled to one side of a housing of a fixing unit, to elastically support a roller installed at an outer portion of a main body between a pair of rollers so that the pair of rollers pressurize each other, a first lever rotatably hinge-coupled to one end of the elastic support member, to rotate the elastic support member at a first predetermined angle so that the pair of rollers are separated from each other, and a side cover rotatably hinge-coupled to one side of the main body, to increase a distance between the pair of rollers by operating the first lever.

Abstract: A method and apparatus to control the fusing temperature of an image forming apparatus. This method of controlling the fusing temperature of an image forming apparatus having a fan to exhaust the internal air to the outside includes counting the accumulated number of sheets of paper printed in response to print commands, lowering a set point of the fusing temperature and controlling the fan to increase the amount of air to be exhausted when the accumulated number of sheets of printed paper is greater than a predetermined value. According to the method, without installing an additional temperature sensor inside the image forming apparatus, the temperature therein can be presumed and controlled by controlling the fusing temperature of the fusing roller and a fan flow rate to lower the temperature of the paper, and consequently, preventing the formation of creases in the paper.

Abstract: An image forming apparatus and a fusing unit thereof. The image forming apparatus includes a photosensitive body on which to form an electrostatic latent image, an exposure device to irradiate light to the photosensitive body to form the electrostatic latent image, a developer adhering device to adhere a developer to the photosensitive body on which the electrostatic latent image has been formed to form a visible image, a transfer device to transfer the visible image formed on the photosensitive body onto a printing medium, and a fusing unit to fuse the visible image transferred onto the printing medium to the printing medium.

Abstract: An image forming apparatus includes a main body frame, an image forming unit disposed inside of the main body frame to form an image, a door unit disposed in such a manner to make a conjoin rotation to thereby approach to a paper transfer path disposed inside of the main body frame, a roller assembly disposed on the paper transfer path, and an opening and closing coupling unit to couple the door unit with the roller assembly, wherein the roller assembly is opened/closed when the door unit is opened/closed.

Abstract: A rollers separating unit which controls a distance between a heating roller and a pressurizing roller of a fixing unit by an opening/closing of a side cover. The rollers separating unit includes an elastic support member rotatably hinge-coupled to one side of a housing of a fixing unit, to elastically support a roller installed at an outer portion of a main body between a pair of rollers so that the pair of rollers pressurize each other, a first lever rotatably hinge-coupled to one end of the elastic support member, to rotate the elastic support member at a first predetermined angle so that the pair of rollers are separated from each other, and a side cover rotatably hinge-coupled to one side of the main body, to increase a distance between the pair of rollers by operating the first lever.

Abstract: An image forming apparatus has an image forming part forming an image on paper, and a housing accommodating the image forming part and having a paper stack part stacking paper discharged from the image forming part, and the image forming apparatus includes an accommodating part formed in an edge of the paper stack part and extending in a paper discharge direction; a base plate mounted in the accommodating part to be slidable in the paper discharge direction and a reverse direction opposite to the paper discharge direction; and a stopper hinge-coupled to the base plate to be tiltable among a stand up position where the stopper blocks paper discharged from the image forming part, a rear folding position where the stopper is folded onto the base plate and is at least partially accommodated in the paper stack part, and a front folding position where the stopper is folded in the paper discharge direction.

Abstract: A sheet separating apparatus for a fusing unit separates a sheet being conveyed through a fusing unit from a heating roller and guides the sheet to a discharging roller without causing damages to a surface of a fusing roller. The sheet separating apparatus comprises a separating claw rotatably disposed toward a discharging side of a heating roller, for separating a sheet from the heating roller, and a contact spring pivoting the separating claw so that a front end of the separating claw is in contact with the heating roller with a predetermined constant pressure. The front end of the separating claw has rounded corners. It is preferred that the front end of the separating claw is chamfered. Also, it is preferred that the separating claw is made of stainless steel.