Abstract: A coacervate including a catechol-substituted anionic polymer; an adhesive including same; and a method for producing the coacervate are described. More specifically, a coacervate formed by mixing a catechol derivative of a mussel adhesive protein and a catechol-substituted anionic polymer; an adhesive including the coacervate; and a method for producing a coacervate are described. The method includes a step of obtaining a catechol-substituted anionic polymer through catechol substitution of an anionic polymer, and a step of mixing the catechol-substituted anionic polymer and a catechol derivative of a mussel adhesive protein.

Abstract: The present invention relates to: a coacervate formed from a catechol-substituted anionic polymer; an adhesive comprising same; and a method for producing same. More specifically, the present invention relates to: a coacervate formed by mixing a catechol derivative of a mussel adhesive protein and a catechol-substituted anionic polymer; an adhesive comprising the coacervate; and a method for producing a coacervate, wherein the method comprises a step of obtaining a catechol-substituted anionic polymer through catechol substitution of an anionic polymer, and a step of mixing the catechol-substituted anionic polymer and a catechol derivative of a mussel adhesive protein.

Abstract: The present disclosure relates to a novel stem cell carrier and a method for producing the same and provides a method for producing a stem cell carrier including a step of contacting stem cells with a coacervate formed by mixing an anionic polymer with a mussel adhesive protein or a mutant thereof. The present disclosure relates to a novel stem cell therapeutic agent platform of delivering cells in a encapsulated state by forming an adhesive cell carrier using crosslinked coacervate. The cell carrier of the present disclosure can maintain the ability to differentiate stem cells as well as biocompatibility and can survive without losing cell adhesion even under oxygen-deficient conditions. In addition, the cell carrier of the present disclosure has an excellent regenerative effect by applying such to biological tissues in which vascular regeneration is not easy, by inducing a metabolic reaction triggered by the hypoxic environment, in particular, neovascularization.

Abstract: The present invention relates to a fusion protein comprising a mussel adhesive protein and a silica-binding peptide linked to the mussel adhesive protein, a silica nanoparticle a silica connected to the fusion protein, a fusion protein-silica nanoparticle complex comprising the silica nanoparticle having bioactivity and adhesiveness for cell proliferation and accelerating the differentiation, a surface coating composition including the complex, its use, and a method of coating a surface using the surface coating composition.

Abstract: Provided are a recombinant polypeptide in which a small leucine-rich proteoglycan mimetic sequence is attached to a terminal of a mussel adhesive protein, a composition for wound healing including the same, a bioadhesive material, and a preparation method thereof. According to the present disclosure, the recombinant polypeptide in which the small leucine-rich proteoglycan mimetic sequence is attached to the terminal of the mussel adhesive protein has an excellent epidermal regeneration effect in which the wound site is uniformly restored by promoting rapid wound healing at the wound site when being applied to the wound site and inducing formation of collagens which are arranged and concentrated at the wound site, and thus can be usefully used as various drugs, cosmetics, and quasi-drugs.

Abstract: The present invention relates to a fusion protein comprising a mussel adhesive protein and a silica-binding peptide linked to the mussel adhesive protein, a silica nanoparticle a silica connected to the fusion protein, a fusion protein-silica nanoparticle complex comprising the silica nanoparticle having bioactivity and adhesiveness for cell proliferation and accelerating the differentiation, a surface coating composition including the complex, its use, and a method of coating a surface using the surface coating composition.

Abstract: The present invention relates to technology of immobilizing or coating various functional bioactive substances on various surfaces without physical chemical treatment using mussel adhesive protein. More specifically, the present invention relates to a functional scaffold for tissue engineering comprising artificial extracellular matrix, manufactured by coating various functional bioactive substances on the surface of nanofiber and metal scaffold using mussel adhesive protein, and a method of manufacturing the same.

Abstract: The present invention relates to a coacervate comprising a mussel adhesive protein and an anionic polymer, and more particularly, to a coacervate prepared by mixing a mussel adhesive protein with an anionic polymer, and a novel use thereof. In the present invention, a coacervate prepared by mixing a mussel adhesive protein and an anionic polymer shows a very excellent adhesive strength to various substrates such as cells or metals, and is able to maintain its adhesive strength in the presence of water or under water, thereby being effectively used as an adhesive. Moreover, it has an activity capable of encapsulating bioactive materials, thereby being effectively used as an active component of a composition for delivering bioactive materials.

Abstract: The present invention relates to technology of immobilizing or coating various functional bioactive substances on various surfaces without physical chemical treatment using mussel adhesive protein. More specifically, the present invention relates to a functional scaffold for tissue engineering comprising artificial extracellular matrix, manufactured by coating various functional bioactive substances on the surface of nanofiber and metal scaffold using mussel adhesive protein, and a method of manufacturing the same.

Abstract: The present invention relates to a coacervate comprising a mussel adhesive protein and an anionic polymer, and more particularly, to a coacervate prepared by mixing a mussel adhesive protein with an anionic polymer, and a novel use thereof. In the present invention, a coacervate prepared by mixing a mussel adhesive protein and an anionic polymer shows a very excellent adhesive strength to various substrates such as cells or metals, and is able to maintain its adhesive strength in the presence of water or under water, thereby being effectively used as an adhesive. Moreover, it has an activity capable of encapsulating bioactive materials, thereby being effectively used as an active component of a composition for delivering bioactive materials.

Abstract: A method of load reduction on buried culvert using an EPS block is disclosed. A culvert foundation is constructed at a place where a culvert will be buried, and the culvert is put on the foundation, and then, both sides of the culvert are banked with filling earth. EPS blocks are paved in multiple layers on the top surface of the culvert, or geosynthetics and an ESP block are paved on the culvert, and then, filling earth is banked on the geosynthetics or the ESP block and a final ground level is compacted. As a result, compression occurs from the EPS block, deformation of the inside earth is caused artificially, and arching is generated. Accordingly, the method has vertical earth pressure reduction effect, thereby preventing an increase in the section of the culvert due to overburden of the banked earth and an increase in vertical load due to a settlement amount of the culvert buried on the weak ground and a relative settlement difference of surrounding earth, and improving durability of the buried culvert.

Abstract: A method of load reduction on buried culvert using an EPS block is disclosed. A culvert foundation is constructed at a place where a culvert will be buried, and the culvert is put on the foundation, and then, both sides of the culvert are banked with filling earth. EPS blocks are paved in multiple layers on the top surface of the culvert, or geosynthetics and an ESP block are paved on the culvert, and then, filling earth is banked on the geosynthetics or the ESP block and a final ground level is compacted. As a result, compression occurs from the EPS block, deformation of the inside earth is caused artificially, and arching is generated. Accordingly, the method has vertical earth pressure reduction effect, thereby preventing an increase in the section of the culvert due to overburden of the banked earth and an increase in vertical load due to a settlement amount of the culvert buried on the weak ground and a relative settlement difference of surrounding earth, and improving durability of the buried culvert.