Patents by Inventor Bonian Liu

Bonian Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10501470
    Abstract: The invention discloses a use of asarinin in preparation of medicines for treating various coughs. The asarinin is used for preparing medicines for treating various coughs separately or in combination with other medicines. The asarinin can be extracted by an SFE-CO2 method. The asarinin and usable drug carriers or excipients are made into various formulations. And the formulations are granules, tablets, capsules, soft capsules, pills, dripping pills, ointments, syrups, injection, oral liquid, tinctures, sustained-releasing drugs, controlled release drugs or targeting preparations.
    Type: Grant
    Filed: September 4, 2017
    Date of Patent: December 10, 2019
    Assignees: THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY, GUANGZHOU INSTITUTE OF RESPIRATORY DISEASE
    Inventors: Kefang Lai, Xiaodong Liu, Bonian Zhong, Shan Zhong, Chuqin Huang
  • Patent number: 10428074
    Abstract: A pyrrole six-membered heteroaryl ring derivative, and the medicinal uses thereof are described. Specifically, the pyrrole six-membered heteroaryl ring derivative is a compound of formula (I), wherein the variable groups are as described in the specification.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: October 1, 2019
    Assignees: Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
    Inventors: Xuejun Zhang, Qing Dong, Bonian Liu, Yaoping Zhu, Xiaotao Li, Jiong Lan
  • Publication number: 20180222912
    Abstract: A pyrrole six-membered heteroaryl ring derivative, and the medicinal uses thereof are described. Specifically, the pyrrole six-membered heteroaryl ring derivative is a compound of formula (I), wherein the variable groups are as described in the specification.
    Type: Application
    Filed: March 22, 2018
    Publication date: August 9, 2018
    Inventors: Xuejun ZHANG, Qing DONG, Bonian LIU, Yaoping ZHU, Xiaotao LI, Jiong LAN
  • Patent number: 9637484
    Abstract: Cycloalkyl acid derivatives, a preparation method thereof, and a pharmaceutical application thereof are described. In particular, a cycloalkyl acid derivative represented by general formula (I) and a medical salt thereof, a preparation method thereof, and an application of the cycloalkyl acid derivative and the medical salt thereof as URAT1 inhibitors, and particularly as therapeutic agents for diseases related to an abnormal uric acid level are described, wherein definitions of substituent groups in general formula (I) are the same as the definitions in the specification.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: May 2, 2017
    Assignees: SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD., JIANGSU HENGRUI MEDICINE CO., LTD.
    Inventors: Jianbiao Peng, Piaoyang Sun, Jiong Lan, Chunyan Gu, Xiaotao Li, Bonian Liu, Chunzhou Han, Qiyue Hu, Fangfang Jin, Qing Dong, Guoqing Cao
  • Publication number: 20170044171
    Abstract: Intermediate compounds used in the preparation of pyrrole six-membered heteroaryl ring derivatives are disclosed. In particular, compounds of formula (IB) are disclosed. The compounds of formula (IB) are used in the synthesis of Janus kinase (JAK) inhibitors. Substituents in formula (IB) have the same definitions as in the description.
    Type: Application
    Filed: November 1, 2016
    Publication date: February 16, 2017
    Inventors: Xuejun ZHANG, Qing DONG, Bonian LIU, Yaoping ZHU, Xiaotao LI, Jiong LAN
  • Patent number: 9527851
    Abstract: The present invention relates to a pyrrole six-membered heteroaryl ring derivative, the preparation method therefor, and the medicinal uses thereof. Specifically, the present invention relates to a new pyrrole six-membered heteroaryl ring derivative as represented by formula (I), the preparation method therefor, a medicinal composition comprising the derivative, and a therapeutic method using same, and, in particular, the uses as a JAK inhibitor and an immunosuppressor. Substituents in formula (I) have the same definitions as in the description.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: December 27, 2016
    Assignees: Jiangsu Hengrui Medicine Co., Ltd., Shanghai Hengrui Pharmaceutical Co., Ltd.
    Inventors: Xuejun Zhang, Qing Dong, Bonian Liu, Yaoping Zhu, Xiaotao Li, Jiong Lan
  • Publication number: 20160108035
    Abstract: Cycloalkyl acid derivatives, a preparation method thereof, and a pharmaceutical application thereof are described. In particular, a cycloalkyl acid derivative represented by general formula (I) and a medical salt thereof, a preparation method thereof, and an application of the cycloalkyl acid derivative and the medical salt thereof as URAT1 inhibitors, and particularly as therapeutic agents for diseases related to an abnormal uric acid level are described, wherein definitions of substituent groups in general formula (I) are the same as the definitions in the specification.
    Type: Application
    Filed: April 29, 2014
    Publication date: April 21, 2016
    Applicant: Shanghai Hengrui Pharmaceutical Co., Lt.d
    Inventors: Jianbiao PENG, Piaoyang SUN, Jiong LAN, Chunyan GU, Xiaotao LI, Bonian LIU, Chunzhou HAN, Qiyue HU, Fangfang JIN, Qing DONG, Guoqing CAO
  • Publication number: 20140336207
    Abstract: The present invention relates to a pyrrole six-membered heteroaryl ring derivative, the preparation method therefor, and the medicinal uses thereof. Specifically, the present invention relates to a new pyrrole six-membered herteroaryl ring derivative as represented by formula (I), the preparation method therefor, a medicinal composition comprising the derivative, and a therapeutic method using same, and, in particular, the uses as a JAK inhibitor and an immunosuppressor. Substituents in formula (I) have the same definitions as in the description.
    Type: Application
    Filed: December 19, 2012
    Publication date: November 13, 2014
    Inventors: Xuejun Zhang, Qing Dong, Bonian Liu, Yaoping Zhu, Xiaotao Li, Jiong Lan