Abstract: Systems and methods of deep learning-based multi-objective pacing content deployment are disclosed. A first set of input parameters is received and a first set of pacing parameters are generated by a trained pacing model that receives the first set of input parameters. The trained pacing model includes a k-nearest neighbor (KNN) portion and Neural Basis Expansion Analysis for Time Series (N-BEATS) portion. In response to generating the first set of pacing parameters, a pacing pipeline is modified to incorporate the set of pacing parameters. The pacing pipeline is configured to generate deployment parameters. Content is deployed to one or more content systems based on the deployment parameters and feedback data representative of the deployed content is received. A second set of pacing parameters is generated by the trained pacing model. The trained pacing model receives a second set of input parameters that are based at least in part on the feedback data.

Abstract: A payload of drug conjugated to a targeting ligand specifically designed to deliver to exhausted CAR T cells to rejuvenate these CAR T cells is provided herein. The targeted CAR T cells are modified with a fusion receptor which can bind to the targeting ligand and internalize the conjugated payload of drug to execute its regulatory function to exhausted CAR T cell.

Abstract: A method including obtaining real-time observed orders per minute (OPM) data. The method also can include training a prediction model to make a real-time OPM prediction for a current time period, based on the real-time observed OPM data over past time steps based on lagged time steps in a moving average. The method additionally can include determining, in real-time, whether a demand surge exists based on the real-time observed OPM data and the real-time OPM prediction, to generate a first surge modifier. The method further can include when the demand surge exists, generating, in real-time, a sub-hour revenue per click (RPC) prediction for a first sub-hour time interval. The method additionally can include determining, in real-time, the first surge modifier for the first sub-hour time interval. The method further can include uploading, in real-time, the first surge modifier to a dayparting system of a search engine to bypass existing time intervals and modifiers. Other embodiments are described.

Abstract: A method including obtaining historical revenue per click (RPC) data. The method also can include generating hourly RPC prediction data for a predetermined time period based on the historical RPC data. The method additionally can include determining (i) time intervals from within the predetermined time period and (ii) a respective modifier for each of the time intervals, based on the hourly RPC prediction data. The acts method can include uploading the time intervals and the respective modifiers for the time intervals to a dayparting system of a search engine. Other embodiments are described.

Abstract: A simulation device and a simulation method for gas reservoir exploitation are provided. The simulation device includes a gas-liquid supply system, a simulation system, a metering system, pipes for interconnecting each system, and switches, wherein: the gas-liquid supply system includes a gas supply system and a liquid supply system; the metering system is for metering gas and/or liquid produced after the simulation system; the simulation system includes core models having at least one of micro-fractures with an aperture smaller than 1 ?m, map-fractures with an aperture between 10-20 ?m, and large-fractures with an aperture between 100-5000 ?m. The present invention is able to accurately simulate water invasion and water-controlled gas production processes of different fractured gas reservoirs under different bottom water energies.

Abstract: A method including obtaining historical revenue per click (RPC) data. The method also can include generating hourly RPC prediction data for a predetermined time period based on the historical RPC data. The method additionally can include determining (i) time intervals from within the predetermined time period and (ii) a respective modifier for each of the time intervals, based on the hourly RPC prediction data. The acts method can include uploading the time intervals and the respective modifiers for the time intervals to a dayparting system of a search engine. Other embodiments are described.

Abstract: A system including one or more processors and one or more non-transitory computer-readable media storing computing instructions configured to run on the one or more processors and perform: receiving, from a user, one or more pre-designed test parameters of an experiment; generating an audience list table comprising one or more identifications (IDs), wherein the one or more IDs link to one or more identification (ID) levels; removing, using identification (ID) mapping, each member of the audience who has an ID that does not satisfy one or more constraints of the one or more ID levels based on the one or more pre-designed test parameters; evaluating, using an evaluation algorithm, whether bias exists for each treatment group of two or more treatment groups; launching the experiment on the members remaining in the audience; and causing at least one result of the experiment to be displayed. Other embodiments are disclosed.

Abstract: The present invention provides a shale gas well dynamic production allocating method.

Abstract: The disclosure provides a weighing structure and adsorbed gas measuring equipment, and belongs to the field of gas detection. The weighing structure comprises a mounting plate connected with a balance, a plurality of mounting rings and lifting devices, a plurality of mounting holes are formed in the mounting plate, and the upper portions of the mounting rings pass through the mounting holes; the lower portions of the mounting rings are provided with suspension wires for hoisting mounted objects, the mounting holes are in clearance fit with the mounting rings, and the lifting devices provide upward supporting force for the mounting rings. The measuring equipment further comprises a kettle body, and a cavity for accommodating the weighing structure and a support for supporting the balance are arranged in the kettle body, wherein weights or a sample cylinder are/is arranged at the lower ends of the suspension wires, and a heating layer and a gas injection nozzle are arranged outside the kettle body.

Abstract: A payload of drug conjugated to a targeting ligand specifically designed to deliver to exhausted CART cells to rejuvenate these CAR T cells is provided herein. The targeted CAR T cells are modified with a fusion receptor which can bind to the targeting ligand and internalize the conjugated payload of drug to execute its regulatory function to exhausted CAR T cell.

Abstract: A simulation device and a simulation method for gas reservoir exploitation are provided. The simulation device includes a gas-liquid supply system, a simulation system, a metering system, pipes for interconnecting each system, and switches, wherein: the gas-liquid supply system includes a gas supply system and a liquid supply system; the metering system is for metering gas and/or liquid produced after the simulation system; the simulation system includes core models having at least one of micro-fractures with an aperture smaller than 1 ?m, map-fractures with an aperture between 10-20 ?m, and large-fractures with an aperture between 100-5000 ?m. The present invention is able to accurately simulate water invasion and water-controlled gas production processes of different fractured gas reservoirs under different bottom water energies.

Abstract: A method including receiving, through a computer network from a search engine, traffic data associated with one or more products, in a time period of a budget period. The method further can include determining an ad-spend amount based at least in part on the traffic data. The method also can include determining a normal range of ad spends for the time period based on a predetermined total allocation amount for the one or more products for the budget period, one or more allocation balancing rules, and/or a spending pattern model. After the normal range is determined, the method further can include detecting an ad-spend anomaly in the time period by monitoring whether the ad-spend amount is outside the normal range. The method additionally can include determining a pacing-control finding that no pacing-control job is being executed. The method further can include transmitting, in real-time through the computer network, an alert to a user in response to the ad-spend anomaly and the pacing-control finding.

Abstract: A method for virtual interaction belongs to the field of communication. The method can include: acquiring a virtual scene corresponding to a user group; acquiring user information of users in the user group, wherein the user information includes face orientation information of the users and first avatar location information of the users; updating display of avatars of the users in the virtual scene based on the user information; determining a display interface based on the face orientation information of a first user corresponding to the current electronic device and the first avatar location information of the first avatar, wherein the display interface includes a virtual scene with a perspective of the first user as an observation point; and displaying the display interface.

Abstract: A method for changing faces for a facial image can include: acquiring three-dimensional facial posture information and three-dimensional facial key points of a target image and a designated image by three-dimensional face reconstruction based on the target image and the designated image; morphing the designated image into an image with the same facial posture information as the target image, the image being used as a reference image; controlling the three-dimensional facial key points, and acquiring two images matched in the three-dimensional facial key points by face-morphing the target image and the reference image; and acquiring a face-changed image by updating a facial texture of the face-morphed target image based on a facial texture of the face-morphed reference image.

Abstract: The present disclosure discloses a method and device for living broadcasting a virtual image. A user can watch the virtual image video in multiple angles, and no clipping occurs when the user adjusts a watching angle as required, thereby improving the user experience.

Abstract: A drug delivery platform providing flexible fine tune of cell therapy is disclosed herein. Particularly, an engineered fusion protein is coupled with a high affinity ligand carrying at least one payload of drug to be internalized by the transplanted cell to observe or regulate transplanted cell therapy effects.

Abstract: Numerical simulation method includes receiving a manufacturing process configuration specification for moving various types of arbitrarily-shaped objects from an egress area onto a lower surface with desired mass flow rate in a predefined time period; creating a FEA model representing the lower surface; creating respective bonded discrete element models (BDEMs) representing the various types of the objects, each BDEM containing discrete elements connected by connection bonds; generating a list of BDEMs each with randomly-chosen types and orientation, such that total mass of the list of BDEMs exceeds a target total mass; and obtaining numerically-simulated physical behaviors of the objects in a time-marching simulation. At each solution cycle of the simulation, placing respective objects into randomly-selected ‘open’ sub-regions by activating next relevant portion of the BDEMs based on the mass flow rate and time-step size; releasing activated BDEMs from the egress area onto the lower surface.

Abstract: Numerical simulation method includes receiving a manufacturing process configuration specification for moving various types of arbitrarily-shaped objects from an egress area onto a lower surface with desired mass flow rate in a predefined time period; creating a FEA model representing the lower surface; creating respective bonded discrete element models (BDEMs) representing the various types of the objects, each BDEM containing discrete elements connected by connection bonds; generating a list of BDEMs each with randomly-chosen types and orientation, such that total mass of the list of BDEMs exceeds a target total mass; and obtaining numerically-simulated physical behaviors of the objects in a time-marching simulation. At each solution cycle of the simulation, placing respective objects into randomly-selected ‘open’ sub-regions by activating next relevant portion of the BDEMs based on the mass flow rate and time-step size; releasing activated BDEMs from the egress area onto the lower surface.

Abstract: Methods and systems for numerically simulating structural failure with clusters of bonded discrete elements representing a failed portion of the structure are disclosed. A computerized mesh model representing a structure is received in a computer system. The computerized mesh model containing at least a plurality of finite elements with a subgroup of adaptive elements included therein. A corresponding cluster of discrete elements and connecting bonds for each adaptive element are created based on a set of predefined criteria. The discrete elements and the connecting bonds are initially set to a state of pre-active, and connecting bonds are used for connecting discrete elements to one another within each cluster. Numerically-calculated structural behaviors are obtained by conducting a time-marching simulation for a predetermined duration in a plurality of solution cycles using the computerized mesh model with a scheme for processing the adaptive elements and corresponding clusters of discrete elements.