Abstract: Disclosed herein are systems, methods, and compositions useful for determining cellular pathway disruption comprising the use of RNA expression level information. This determined level of disruption can assist in the identification of genetic variants that alter pathway activity, to correlate these variants with disease state and disease progression, and to identify those therapeutics most likely to be effective and which should be avoided.

Abstract: In general, the invention is directed to a coaxial cable antenna for use in an external device, such as a programmer or monitor, to enhance communication between the external device and an implanted medical device (IMD). The coaxial cable antenna provides the external device with polarization diversity. For example, the coaxial cable antenna includes a first portion and a second portion that are substantially perpendicular to one another. Each of the portions of the coaxial cable antenna has a different polarization orientation, thus providing the programmer with polarization diversity. Further, the external device may include more than one coaxial cable antenna to provide the external device with spatial diversity as well as polarization diversity provided by the coaxial cable antenna design. The coaxial cable antenna configurations reduce problems associated with polarization mismatches, antenna nulls, and multi-path propagation interference.

Abstract: A coaxial cable antenna is provided for use in an external device, such as a programmer or monitor, to enhance communication between the external device and an implanted medical device (IMD). The coaxial cable antenna provides the external device with polarization diversity. For example, the coaxial cable antenna includes a first portion and a second portion that are substantially perpendicular to one another. Each of the portions of the coaxial cable antenna has a different polarization orientation, thus providing the programmer with polarization diversity. Further, the external device may include more than one coaxial cable antenna to provide the external device with spatial diversity as well as polarization diversity provided by the coaxial cable antenna design. The coaxial cable antenna configurations reduce problems associated with polarization mismatches, antenna nulls, and multi-path propagation interference.

Abstract: Improved telemetry antennas and methods of fabrication for an implantable medical device (IMD) for use in uplink telemetry (UT) and downlink telemetry (DT) transmissions between the IMD and an external medical device (EMD) are disclosed. A first telemetry antenna element is supported to extend in a first direction along a minor side of the IMD housing by a first header segment, and a second antenna element is supported to extend in a second direction along a second minor side of the IMD housing by a second header segment. The first and second antenna elements are supported to extend apart at substantially 90° to one another, i.e., substantially orthogonally, in substantially a common plane to optimize UT transmission and DT reception of UHF telemetry signals by at least one of the first and second antenna elements depending upon the mutual spatial orientation with the antenna elements of an EMD antenna.

Abstract: A method and an apparatus for reducing coupled electrical energy resulting from an electromagnetic field. Embodiments of the present invention provide for an elongate body having a proximal end portion, a middle portion, and a distal end portion and at least one coil wound about at least one of the proximal end portion, the middle portion, and the distal end portion, the coil to provide for filtering of radio frequency (RF) signal-coupled electrical energy.

Abstract: A coaxial cable antenna for use in an external device, such as a programmer or monitor, to enhance communication between the external device and an implanted medical device (IMD). The coaxial cable antenna provides the external device with polarization diversity. For example, the coaxial cable antenna includes a first portion and a second portion that are substantially perpendicular to one another. Each of the portions of the coaxial cable antenna has a different polarization orientation, thus providing the programmer with polarization diversity. Further, the external device may include more than one coaxial cable antenna to provide the external device with spatial diversity as well as polarization diversity provided by the coaxial cable antenna design. The coaxial cable antenna configurations reduce problems associated with polarization mismatches, antenna nulls, and multi-path propagation interference.

Abstract: Improved telemetry antennas and methods of fabrication for an implantable medical device (IMD) for use in uplink telemetry (UT) and downlink telemetry (DT) transmissions between the IMD and an external medical device (EMD) are disclosed. A first telemetry antenna element is supported to extend in a first direction along a minor side of the IMD housing by a first header segment, and a second antenna element is supported to extend in a second direction along a second minor side of the IMD housing by a second header segment. The first and second antenna elements are supported to extend apart at substantially 90° to one another, i.e., substantially orthogonally, in substantially a common plane to optimize UT transmission and DT reception of UHF telemetry signals by at least one of the first and second antenna elements depending upon the mutual spatial orientation with the antenna elements of an EMD antenna.