Patents by Inventor Bonnie B. Plikaytis

Bonnie B. Plikaytis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptide vaccine and vaccination strategy against mycobacterium
    Patent number: 8741313
    Abstract: A vaccine is provided wherein a polypeptide or combination of peptides from M. tuberculosis is administered to a subject to elicit an immune response. The polypeptide vaccine is administered as part of a prime-boost strategy with BCG vaccine to increase the immunoprotection in a subject such that prevention or elimination of disease is achieved. Finally, a pharmaceutical package is provided that encompasses a polypeptide vaccine for M. tuberculosis that when administered to a subject elicits immunoprotection.
    Type: Grant
    Filed: January 12, 2009
    Date of Patent: June 3, 2014
    Assignees: Emory University, The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Suraj Sable, Bonnie B. Plikaytis, Thomas M. Shinnick, Rama Rao Amara, Manl Cheruvu
  • POLYPEPTIDE VACCINE AND VACCINATION STRATEGY AGAINST MYCOBACTERIUM
    Publication number: 20110027349
    Abstract: A vaccine is provided wherein a polypeptide or combination of peptides from M. tuberculosis is administered to a subject to elicit an immune response. The polypeptide vaccine is administered as part of a prime-boost strategy with BCG vaccine to increase the immunoprotection in a subject such that prevention or elimination of disease is achieved. Finally, a pharmaceutical package is provided that encompasses a polypeptide vaccine for M. tuberculosis that when administered to a subject elicits immunoprotection.
    Type: Application
    Filed: January 12, 2009
    Publication date: February 3, 2011
    Inventors: Suraj Sable, Bonnie B. Plikaytis, Thomas M. Shinnick
  • Rapid amplification-based subtyping of mycobacterium tuberculosis
    Patent number: 5652106
    Abstract: The present invention provides methods of detecting or distinguishing the DNA of an individual strain of Mycobacterium tuberculosis utilizing the polymerase chain reaction (PCR). Reproducible, unique patterns can be produced allowing the identification of unknown M. tuberculosis DNA by performing this reaction and comparing the pattern produced to the known reproducible, unique patterns. The invention further provides a kit useful to detect or distinguish the DNA of an individual strain of M. tuberculosis in a sample, comprising specific primers for use in PCR. The present invention also provides a method of determining the presence of a multidrug-resistant M. tuberculosis by detecting the presence of a specific arrangement of genomic DNA. Such detection can be done using PCR or a ligase chain reaction (LCR). The present invention provides nucleic acid sequences useful in detecting multidrug-resistant M. tuberculosis.
    Type: Grant
    Filed: October 25, 1995
    Date of Patent: July 29, 1997
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Bonnie B. Plikaytis, Thomas M. Shinnick, Jack T. Crawford
  • Immunodiagnostic reagent specific for legionella
    Patent number: 5248594
    Abstract: A set of three unique monoclonal antibodies have been produced which recognize Legionella with particular specificity, without substantial cross-reactivity with non-Legionella bacteria. These monoclonal antibodies are useful as immunodiagnostic reagents for detecting Legionella.
    Type: Grant
    Filed: July 5, 1990
    Date of Patent: September 28, 1993
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Carol H. Aloisio, George M. Carlone, Bonnie B. Plikaytis, Jackie Sampson