Patents by Inventor Bonno Nammen Bouma

Bonno Nammen Bouma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein S deletion variants deficient in C4BP binding activity, but having APC cofactor activity, compositions and therapeutic methods
    Patent number: 5663142
    Abstract: The present invention relates to various functional variants of recombinant protein S (PS) that do not significantly bind C4b binding protein (C4BP) and uses of the variants as a therapeutic reagent. In particular the invention is directed at deletion mutants of protein S, having cofactor activity toward APC and lacking at least the two postulated C4BP binding domains of the SHBG-like domain of the corresponding mature wild type protein S. Such a deletion mutant in particular lacks at least amino acid residues 401-457 and 583-635 of the corresponding mature wild type human protein S.
    Type: Grant
    Filed: June 29, 1994
    Date of Patent: September 2, 1997
    Assignees: Rijksuniversiteit Leiden, Bonno Nammen Bouma
    Inventors: Bonno Nammen Bouma, Rogier Maria Bertina
  • Protein S deletion variants deficient in C4BP binding activity but having APC cofactor activity compositions and therapeutic methods
    Patent number: 5656484
    Abstract: The present invention relates to various functional variants of recombinant protein S (PS) that do not significantly bind C4b binding protein (C4BP) and uses of the variants as a therapeutic reagent. In particular the invention is directed at deletion mutants of protein S, having cofactor activity toward APC and lacking at least the two postulated C4BP binding domains of the SHBG-like domain of the corresponding mature wild type protein S. Such a deletion mutant in particular lacks at least amino acid residues 401-457 and 583-635 of the corresponding mature wild type human protein S.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: August 12, 1997
    Assignees: Rijksuniversiteit Leiden, Bonno Nammen Bouma
    Inventors: Bonno Nammen Bouma, Rogier Maria Bertina