Patents by Inventor Bor-Shyue Hong

Bor-Shyue Hong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATING DRY EYE
    Publication number: 20090131303
    Abstract: The present invention is directed to ophthalmic compositions containing protease-inhibiting peptide substrates. In a preferred embodiment, the protease-inhibiting peptide substrate is gelatin. The compositions may also contain a galactomannan. In a particularly preferred embodiment, the compositions contain gelatin, a galactomannan and a borate salt. The present invention also describes methods of use of these compositions to inhibit protease MMP-9, and methods of topical administration of the compositions to the eye, particularly for the treatment of dry eye.
    Type: Application
    Filed: November 13, 2008
    Publication date: May 21, 2009
    Inventors: BOR-SHYUE HONG, DAVID L. MEADOWS
  • Use of multifunctional surface active agents to clean contact lenses
    Patent number: 6995123
    Abstract: Cleaning compositions for contact lenses are described. The compositions contain multifunctional anionic surfactants that include at least two hydrophilic dissociating head groups. The multifunctional surfactants described (e.g., LED3A) possess both surface active and chelating properties, and have been found to be particularly effective in removing protein deposits from contact lenses.
    Type: Grant
    Filed: December 17, 2003
    Date of Patent: February 7, 2006
    Assignee: Alcon, Inc.
    Inventors: Howard Allen Ketelson, David L. Meadows, Bor-Shyue Hong
  • Use of multifunctional surface active agents to clean contact lenses
    Publication number: 20050282715
    Abstract: Cleaning compositions for contact lenses are described. The compositions contain multifunctional anionic surfactants that include at least two hydrophilic dissociating head groups. The multifunctional surfactants described (e.g., LED3A) possess both surface active and chelating properties, and have been found to be particularly effective in removing protein deposits from contact lenses.
    Type: Application
    Filed: August 24, 2005
    Publication date: December 22, 2005
    Inventors: Howard Ketelson, David Meadows, Bor-Shyue Hong
  • Use of multifunctional surface active agents to clean contact lenses
    Publication number: 20040127372
    Abstract: Cleaning compositions for contact lenses are described. The compositions contain multifunctional anionic surfactants that include at least two hydrophilic dissociating head groups. The multifunctional surfactants described (e.g., LED3A) possess both surface active and chelating properties, and have been found to be particularly effective in removing protein deposits from contact lenses.
    Type: Application
    Filed: December 17, 2003
    Publication date: July 1, 2004
    Inventors: Howard Allen Ketelson, David L. Meadows, Bor-Shyue Hong
  • Contact lens care compositions containing chitosan derivatives
    Publication number: 20040121924
    Abstract: The use of compositions containing anionic chitosan derivatives to treat contact lenses is described. The compositions are particularly useful for removing protein deposits from contact lenses, but also serve to lubricate the surfaces of the lenses and enhance the comfort of the lenses when worn on the eyes.
    Type: Application
    Filed: December 10, 2003
    Publication date: June 24, 2004
    Inventors: Bor-Shyue Hong, David L. Meadows, Howard Allen Ketelson, Geoffrey Robert Owen
  • Contact lens care compositions containing chitin derivatives
    Publication number: 20040121923
    Abstract: The use of compositions containing chitin derivatives to treat contact lenses is described. The compositions are particularly useful for removing protein deposits from contact lenses, but also serve to lubricate the surfaces of the lenses and enhance the comfort of the lenses when worn on the eyes. The chitin derivatives are preferably nonionic (e.g., ethylene glycol chitin), and facilitate the removal of protein deposits from contact lenses by functioning as a substrate for the lysozyme contained in those deposits.
    Type: Application
    Filed: December 10, 2003
    Publication date: June 24, 2004
    Inventors: Bor-Shyue Hong, David L. Meadows, Howard Allen Ketelson, Geoffrey Robert Owen
  • Alkyl trypsin compositions and methods of use in contact lens cleaning and disinfecting systems
    Patent number: 6358897
    Abstract: Improved stability, liquid enzyme compositions containing an alkylated trypsin and methods involving the combined use of these compositions with an aqueous composition are disclosed for the cleaning or simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: March 19, 2002
    Assignee: Alcon Laboratories, Inc.
    Inventors: Bor-Shyue Hong, Bahram Asgharian, Ronald P. Quintana
  • Multi-purpose compositions containing an alkyl-trypsin and methods of use in contact lens cleaning and disinfecting
    Patent number: 6228323
    Abstract: Two-compartment bottle assemblies useful in preparing multi-purpose compositions containing an Al-trypsin and disinfectant, methods of preparing these compositions and methods involving the use of these compositions are disclosed for cleaning and disinfecting of contact lenses.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: May 8, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Bahram Asgharian, Bor-Shyue Hong
  • Liquid enzyme compositions and methods of use in contact lens cleaning and disinfecting systems
    Patent number: 6214596
    Abstract: Stable liquid enzyme compositions containing an ophthalmically acceptable enzyme and methods involving the combined use of these compositions with an antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: April 10, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Bahram Asgharian, Bor-Shyue Hong
  • Liquid enzyme compositions and methods of use in contact lens cleaning and disinfecting systems
    Patent number: 6184189
    Abstract: Stable liquid enzyme compositions containing an ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lenses. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: February 6, 2001
    Assignee: Alcon Laboratories, Inc.
    Inventors: Bahram Asgharian, Bor-Shyue Hong
  • Alkyl trypsin compositions and methods of use in contact lens cleaning and disinfecting systems
    Patent number: 6139646
    Abstract: Improved stability, liquid enzyme compositions containing an alkylated trypsin and methods involving the combined use of these compositions with an aqueous composition are disclosed for the cleaning or simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: October 31, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Bahram Asgharian, Bor-Shyue Hong, Ronald P. Quintana
  • Liquid enzyme compositions containing mixed polyols and methods of use
    Patent number: 6069120
    Abstract: Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: May 30, 2000
    Assignee: Alcon Laboratories, Inc.
    Inventors: Bahram Asgharian, Bor-Shyue Hong
  • Stable liquid enzyme compositions and methods of use in contact lens cleaning and disinfecting systems
    Patent number: 5948738
    Abstract: Stable liquid enzyme compositions containing an ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: October 6, 1998
    Date of Patent: September 7, 1999
    Assignee: Alcon Laboratories, Inc.
    Inventors: Masood A. Chowhan, Ronald P. Quintana, Bahram Asgharian, Bor-Shyue Hong, Thierry Bilbault, Ruth A. Rosenthal
  • Stable liquid enzyme compositions and methods of use in contact lens cleaning and disinfecting systems
    Patent number: 5939369
    Abstract: Stable liquid enzyme compositions containing an ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: August 17, 1999
    Assignee: Alcon Laboratories, Inc.
    Inventors: Masood A. Chowhan, Ronald P. Quintana, Bahram Asgharian, Bor-Shyue Hong, Thierry Bilbault, Ruth A. Rosenthal
  • Liquid enzyme compositions containing aromatic acid derivatives and methods of use
    Patent number: 5919313
    Abstract: Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: July 6, 1999
    Assignee: Alcon Laboratories, Inc.
    Inventors: Bahram Asgharian, Ronald P. Quintana, Bor-Shyue Hong
  • Peg-modified proteases and methods of use in contact lens cleaning
    Patent number: 5868868
    Abstract: The invention discloses PEG-modified proteases, compositions containing these modified enzymes, and methods for using them to clean contact lenses. The methods of the present invention are also directed to the simultaneous cleaning and disinfecting of contact lenses, when compositions of the present invention are combined with a suitable disinfectant.
    Type: Grant
    Filed: March 19, 1997
    Date of Patent: February 9, 1999
    Assignee: Alcon Laboratories, Inc.
    Inventors: Joonsup Park, Ronald P. Quintana, Bor-shyue Hong, Bahram Asgharian
  • Stable liquid enzyme compositions and methods of use in contact lens cleaning and disinfecting systems
    Patent number: 5723421
    Abstract: Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: October 18, 1995
    Date of Patent: March 3, 1998
    Assignee: Alcon Laboratories, Inc.
    Inventors: Masood A. Chowhan, Ronald P. Quintana, Bahram Asgharian, Bor-Shyue Hong, Thierry Bilbault, Ruth Ann Rosenthal
  • Enzymes with low isoelectric points for use in contact lens cleaning
    Patent number: 5718895
    Abstract: Compositions containing an ophthalmically acceptable, modified enzyme exhibiting a low pI and methods involving the combined use of these compositions with a polymeric antimicrobial agent, are disclosed for the simultaneous cleaning and disinfecting of contact lens.
    Type: Grant
    Filed: November 16, 1995
    Date of Patent: February 17, 1998
    Assignee: Alcon Laboratories, Inc.
    Inventors: Bahram Asgharian, Bor-Shyue Hong, Ronald P. Quintana
  • Liquid enzyme compositions containing aromatic acid derivatives
    Patent number: 5672213
    Abstract: Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: August 18, 1995
    Date of Patent: September 30, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Bahram Asgharian, Ronald P. Quintana, Bor-Shyue Hong
  • Methods of using liquid enzyme compositions containing mixed polyols
    Patent number: 5605661
    Abstract: Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
    Type: Grant
    Filed: August 18, 1995
    Date of Patent: February 25, 1997
    Assignee: Alcon Laboratories, Inc.
    Inventors: Bahram Asgharian, Bor-Shyue Hong