Patents by Inventor Bor-Wen Wu

Bor-Wen Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treatment with arginine deiminase
    Patent number: 10525142
    Abstract: The present invention relates generally to methods of treating cancer with arginine deiminase, and in particular pegylated arginine deiminase.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: January 7, 2020
    Assignee: Polaris Group
    Inventors: John S. Bomalaski, Bor-Wen Wu
  • Engineered chimeric pegylated ADI and methods of use
    Patent number: 10463721
    Abstract: Provided are chimeric arginine deiminases, including pegylated chimeric arginine deiminases, and related compositions and methods of use thereof, including methods of treating cancer.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: November 5, 2019
    Assignee: TDW Group
    Inventors: Bor-Wen Wu, Robert Almassy, Wei He, Richard E. Showalter, Jiaojuan He, Yunyun Guo, James A. Thomson
  • FORMULATIONS OF PEGYLATED ARGININE DEIMINASE
    Publication number: 20180296652
    Abstract: Provided are lyophilized formulations comprising pegylated arginine deiminase (ADI-PEG) and related reconstituted liquid compositions and methods of using the compositions for arginine depletion therapies, including for the treatment of various cancers.
    Type: Application
    Filed: November 2, 2017
    Publication date: October 18, 2018
    Inventors: Bor-Wen Wu, James Thomson, Wen-Chin Tsai
  • METHODS OF TREATMENT WITH ARGININE DEIMINASE
    Publication number: 20180154008
    Abstract: The present invention relates generally to methods of treating cancer with arginine deiminase, and in particular pegylated arginine deiminase.
    Type: Application
    Filed: July 12, 2017
    Publication date: June 7, 2018
    Inventors: John S. Bomalaski, Bor-Wen Wu
  • Antibodies to argininosuccinate synthase and related methods
    Patent number: 9938355
    Abstract: Antibodies, and antigen-binding fragments, which specifically bind to argininosuccinate synthase, and related compositions, kits, and methods of use, which are useful as companion diagnostics to identify suitable subjects for arginine deprivation or depletion therapies such as ADI-PEG 20 and other arginine deiminase (ADI) polypeptide-based therapies.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: April 10, 2018
    Assignee: TDW Group
    Inventors: Wei He, Yunyun Guo, Bor-Wen Wu
  • Methods of treatment with arginine deiminase
    Patent number: 9731028
    Abstract: The present invention relates generally to methods of treating cancer with arginine deiminase, and in particular pegylated arginine deiminase.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: August 15, 2017
    Assignee: Polaris Group
    Inventors: John S. Bomalaski, Bor-Wen Wu
  • ENGINEERED CHIMERIC PEGYLATED ADI AND METHODS OF USE
    Publication number: 20170000862
    Abstract: Provided are chimeric arginine deiminases, including pegylated chimeric arginine deiminases, and related compositions and methods of use thereof, including methods of treating cancer.
    Type: Application
    Filed: March 18, 2015
    Publication date: January 5, 2017
    Inventors: Bor-Wen Wu, Robert Almassy, Wei He, Richard E. Showalter, Jiaojuan He, Yunyun Guo, James A. Thomson
  • Methods of treatment with arginine deiminase
    Patent number: 9333268
    Abstract: The present invention relates generally to methods of treating cancer with arginine deiminase, and in particular pegylated arginine deiminase.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: May 10, 2016
    Assignee: Polaris Group
    Inventors: John S. Bomalaski, Bor-Wen Wu
  • ANTIBODIES TO ARGININOSUCCINATE SYNTHASE AND RELATED METHODS
    Publication number: 20160009821
    Abstract: Provided are antibodies, and antigen-binding fragments thereof, which specifically bind to argininosuccinate synthase, and related compositions, kits, and methods of use thereof, for instance, as companion diagnostics to identify suitable subjects for arginine deprivation or depletion therapies such as ADI-PEG 20 and other arginine deiminase (ADI) polypeptide-based therapies.
    Type: Application
    Filed: July 8, 2015
    Publication date: January 14, 2016
    Inventors: Wei He, Yunyun Guo, Bor-Wen Wu
  • METHODS OF TREATMENT WITH ARGININE DEIMINASE
    Publication number: 20150231272
    Abstract: The present invention relates generally to methods of treating cancer with arginine deiminase, and in particular pegylated arginine deiminase.
    Type: Application
    Filed: May 1, 2015
    Publication date: August 20, 2015
    Inventors: John S. Bomalaski, Bor-Wen Wu
  • METHODS OF TREATMENT WITH ARGININE DEIMINASE
    Publication number: 20150132278
    Abstract: The present invention relates generally to methods of treating cancer with arginine deiminase, and in particular pegylated arginine deiminase.
    Type: Application
    Filed: May 30, 2012
    Publication date: May 14, 2015
    Inventors: John S. Bomalaski, Bor-Wen Wu