Patents by Inventor Boris Cheskis

Boris Cheskis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Functional method for generating or screening for ligands which modulate steroid hormone receptors
    Publication number: 20050202515
    Abstract: This application presents the discovery that the Vitamin D3 receptor (VDR), a member of the nuclear hormone ligand-activated receptor superfamily, interacts with a MNAR, a scaffolding protein. This interaction results in the formation of a ternary complex between VDR, MNAR, and the Src or PI3 kinase families of tyrosine kinases to mediate cell signaling, especially in osteoblast cells.
    Type: Application
    Filed: February 25, 2005
    Publication date: September 15, 2005
    Applicant: Wyeth
    Inventors: Frank Barletta, Greg O'Donnell, Boris Cheskis
  • Novel modulator of non-genomic activity of nuclear receptors (mnar) and uses thereof
    Publication number: 20050142634
    Abstract: A novel protein modulator of non-genomic activity of nuclear receptors (MNAR), which interacts with estrogen receptors alpha (ER?), estrogen receptor beta (ER?), and other nuclear receptors, was discovered and characterized. An MNAR-ER complex, in vitro and in vivo, relates to nucleic acids, antisense, recombinant expression of nucleic acids, as well as host cells, compositions and assays that utilize the nucleic acids and protein of this invention.
    Type: Application
    Filed: April 3, 2002
    Publication date: June 30, 2005
    Applicant: Wyeth
    Inventors: Boris Cheskis, Elliott Nickbarg, Chi-Wai Wong