Patents by Inventor Boris Freger

Boris Freger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7579461
    Abstract: A novel process for preparing (2?,3?,5?,16?,17?)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl) androstane, a known intermediate in the synthesis of the skeletal muscle relaxant rocuronium bromide, is disclosed.
    Type: Grant
    Filed: January 13, 2005
    Date of Patent: August 25, 2009
    Assignee: Chemagis Ltd.
    Inventors: Eliezer Adar, David Sondack, Oded Friedman, Iosef Manascu, Tamir Fizitzki, Boris Freger, Oded Arad, Alexander Weisman, Joseph Kaspi
  • Patent number: 7538230
    Abstract: Provided is a method for preparing letrozole, which includes reacting an activated bis-(4-cyanophenyl)-methane with a triazole to produce letrozole, and, optionally, purifying the letrozole. Also provided are highly pure letrozole, and a method of purifying letrozole, which method includes precipitating letrozole, e.g., by selective precipitation from a reaction mixture and/or by subjecting the letrozole to one or more crystallizations.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: May 26, 2009
    Assignee: Chemagis Ltd.
    Inventors: Oded Friedman, Boris Freger, Olga Etlin, Julia Ditkovitch, Edna Danon, Yana Seryi, Guy Davidi, Oded Arad, Joseph Kaspi
  • Publication number: 20070112202
    Abstract: Provided is a method for preparing letrozole, which includes reacting an activated bis-(4-cyanophenyl)-methane with a triazole to produce letrozole, and, optionally, purifying the letrozole. Also provided are highly pure letrozole, and a method of purifying letrozole, which method includes precipitating letrozole, e.g., by selective precipitation from a reaction mixture and/or by subjecting the letrozole to one or more crystallizations.
    Type: Application
    Filed: November 14, 2005
    Publication date: May 17, 2007
    Applicant: CHEMAGIS LTD.
    Inventors: Oded Friedman, Boris Freger, Olga Etlin, Julia Ditkovitch, Edna Danon, Yana Seryi, Guy Davidi, Oded Arad, Joseph Kaspi
  • Publication number: 20060058276
    Abstract: Processes are provided herein for the preparation of pure rocuronium bromide and for the purification of impure rocuronium bromide obviating the need for column chromatography and that can be easily, conveniently and inexpensively scaled-up.
    Type: Application
    Filed: July 14, 2005
    Publication date: March 16, 2006
    Inventors: Oded Friedman, Oded Arad, Iosef Manascu, Tamir Fizitzki, Boris Freger, Joseph Kaspi
  • Publication number: 20060035950
    Abstract: The present invention provides novel processes for purifying anastrozole, devoid of using liquid chromatography. The purification processes are via the isolated anastrozole salt forms, either by crystallization or by selective acidic extractions, and optionally in both cases, converting the purified anastrozole salt to anastrozole base. Also provided is an improved process for the synthesis of anastrozole, which is obtained by alkylating the isolated and purified starting material 3,5-bis(2-cyanoprop-2-yl)benzylbromide, the process being devoid of using toxic, hazardous and environmental unfriendly solvents and reagents.
    Type: Application
    Filed: August 9, 2005
    Publication date: February 16, 2006
    Inventors: Mohammed Alnabari, Boris Freger, Oded Arad, Lior Zelikovitch, Yana Seryi, Edna Danon, Guy Davidi, Joseph Kaspi
  • Publication number: 20050159398
    Abstract: A novel process for preparing (2?,3?,5?,16?,17?)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane, a known intermediate in the synthesis of the skeletal muscle relaxant rocuronium bromide, is disclosed.
    Type: Application
    Filed: January 13, 2005
    Publication date: July 21, 2005
    Inventors: Eliezer Adar, David Sondack, Oded Friedman, Iosef Manascu, Tamir Fizitzki, Boris Freger, Oded Arad, Alexander Weisman, Joseph Kaspi