Abstract: An apparatus collects data from a data network for the purpose of detection and interception of security incidents therein. The apparatus identifies at least one event in the data network. The apparatus then inspects the event to identify its properties and metadata associated therewith. Based on the inspection, the apparatus identifies at least a type of the event, an operation and a resource associated with the event, and a device associated with the event. The metadata is the matched to a unified index stored in a database communicatively coupled to the apparatus via a network. Based on the match the apparatus determines whether the event is potentially a security incident. In case a determination of a potential security incident is made, the apparatus queries a set of set of policy rules to determine a type of action required respective of the metadata. The apparatus then performs the required action.

Abstract: A method for agentless monitoring of third-party applications is disclosed. The method includes: initiating by a monitoring agentless application (MAA) executing on a computer a service instance in a cloud-based computing environment of a software as a service (SaaS); providing, to a third-party application by the MAA, application access credentials for use in accessing the service instance; and extracting, by the MAA, behavior data from the service instance based on at least an action performed by the third-party application in the service instance.

Abstract: A method for generating a threat indicator for a third-party application. The method includes: obtaining, by a monitoring agentless application (MAA) executing on a computer, a predetermined set of attributes of a third-party application that operates on top of a software as a service (SaaS) instance, wherein the third party-application is a SaaS add-on; obtaining, by the MAA, behavior data from the SaaS instance based on at least an action performed by the third-party application in the SaaS instance; and generating a threat indicator for the third-party application based on the predetermined set of attributes and the behavior data.

Abstract: Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.

Abstract: An apparatus collects data from a data network for the purpose of detection and interception of security incidents therein. The apparatus identifies at least one event in the data network. The apparatus then inspects the event to identify its properties and metadata associated therewith. Based on the inspection, the apparatus identifies at least a type of the event, an operation and a resource associated with the event, and a device associated with the event. The metadata is the matched to a unified index stored in a database communicatively coupled to the apparatus via a network. Based on the match the apparatus determines whether the event is potentially a security incident. In case a determination of a potential security incident is made, the apparatus queries a set of set of policy rules to determine a type of action required respective of the metadata. The apparatus then performs the required action.

Abstract: The disclosure features polymorphs of a prodrug dimer of dexamethasone linked at the 21-C and 21?-C carbons via a carbonate-triethylene glycol-carbonate linker. Also disclosed are pharmaceutical compositions and articles comprising said polymorphs, and the use thereof in the treatment of a disease or condition, e.g. via the extended or controlled release of dexamethasone from said articles.

Abstract: Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.

Abstract: The present invention provides novel crystalline forms of Ponatinib hydrochloride. Specific crystalline forms provided by the present invention include Ponatinib hydrochloride Form APO-I, APO-III and APO-IV, each of which is obtained from acetonitrile/formic acid solutions. Additionally, Form APO-V is provided, which is obtained from concentrated hydrochloric acid.

Abstract: Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.

Abstract: The present invention provides processes for the preparation of Acalabrutinib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for coupling of a compound of Formula (5) and 2-butynoic acid in the presence of Carbodiimide (8) to afford Acalabrutinib (1).

Abstract: Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.

Abstract: The present invention provides processes for the preparation of Veliparib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (3), or a salt thereof, and cyclization to afford Veliparib (1).

Abstract: An apparatus collects data from a data network for the purpose of detection and interception of security incidents therein. The apparatus identifies at least one event in the data network. The apparatus then inspects the event to identify its properties and metadata associated therewith. Based on the inspection, the apparatus identifies at least a type of the event, an operation and a resource associated with the event, and a device associated with the event. The metadata is the matched to a unified index stored in a database communicatively coupled to the apparatus via a network. Based on the match the apparatus determines whether the event is potentially a security incident. In case a determination of a potential security incident is made, the apparatus queries a set of set of policy rules to determine a type of action required respective of the metadata. The apparatus then performs the required action.

Abstract: The present invention provides novel crystalline forms of Ponatinib hydrochloride. Specific crystalline forms provided by the present invention include Ponatinib hydrochloride Form APO-I, APO-III and APO-IV, each of which is obtained from acetonitrile/formic acid solutions. Additionally, Form APO-V is provided, which is obtained from concentrated hydrochloric acid.

Abstract: An apparatus collects data from a data network for the purpose of detection and interception of security incidents therein. The apparatus identifies at least one event in the data network. The apparatus then inspects the event to identify its properties and metadata associated therewith. Based on the inspection, the apparatus identifies at least a type of the event, an operation and a resource associated with the event, and a device associated with the event. The metadata is the matched to a unified index stored in a database communicatively coupled to the apparatus via a network. Based on the match the apparatus determines whether the event is potentially a security incident. In case a determination of a potential security incident is made, the apparatus queries a set of set of policy rules to determine a type of action required respective of the metadata. The apparatus then performs the required action.

Abstract: The present invention provides processes for the preparation of Acalabrutinib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for coupling of a compound of Formula (5) and 2-butynoic acid in the presence of Carbodiimide (8) to afford Acalabrutinib (1).

Abstract: The present invention provides processes for the preparation of Veliparib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for the production of the compound of Formula (3), or a salt thereof, and cyclization to afford Veliparib (1).

Abstract: The present invention provides processes for the preparation of Apalutamide (1), as well as intermediates useful in the preparation thereof. In particular, the process of the invention utilizes the intermediate compound of Formula (2), wherein G is OH or a leaving group, which provides improvements over the known processes for the preparation of Apalutamide (1).

Abstract: Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter cilia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.

Abstract: The present invention provides continuous flow processes for the preparation of the compound of Formula (1), an intermediate in the preparation of Vilazodone.