Patents by Inventor Boris Nikolic

Boris Nikolic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240181047
    Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
    Type: Application
    Filed: December 29, 2023
    Publication date: June 6, 2024
    Inventors: Ana Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, JR., Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
  • Patent number: 11975069
    Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
    Type: Grant
    Filed: January 7, 2021
    Date of Patent: May 7, 2024
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, TOKITAE LLC
    Inventors: Ana Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, Jr., Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
  • Publication number: 20230372254
    Abstract: Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.
    Type: Application
    Filed: December 16, 2022
    Publication date: November 23, 2023
    Inventors: Ana Jaklenec, Xian Xu, Lowell L. Wood, Jr., Philip A. Welkhoff, William Gates, Boris Nikolic, Robert S. Langer
  • Patent number: 11541017
    Abstract: Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: January 3, 2023
    Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, TOKITAE LLC
    Inventors: Ana Jaklenec, Xian Xu, Lowell L. Wood, Jr., Philip A. Welkhoff, William Gates, Boris Nikolic, Robert S. Langer
  • Publication number: 20210205444
    Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
    Type: Application
    Filed: January 7, 2021
    Publication date: July 8, 2021
    Inventors: Ana Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, JR., Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
  • Patent number: 10960073
    Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: March 30, 2021
    Assignees: TOKITAE LLC, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Ana Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, Jr., Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
  • Publication number: 20190328871
    Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
    Type: Application
    Filed: May 2, 2019
    Publication date: October 31, 2019
    Inventors: Ana Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, JR., Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
  • Patent number: 10300136
    Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: May 28, 2019
    Assignees: Massachusetts Institute of Technology, Tokitae LLC
    Inventors: Ana Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
  • Publication number: 20170216216
    Abstract: Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.
    Type: Application
    Filed: April 11, 2017
    Publication date: August 3, 2017
    Inventors: Ana Jaklenec, Xian Xu, Lowell L. Wood, JR., Philip A. Eckhoff, William Gates, Boris Nikolic, Robert S. Langer
  • Patent number: 9649279
    Abstract: Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: May 16, 2017
    Assignees: Massachusetts Institute of Technology, Tokitae LLC
    Inventors: Ana Jaklenec, Xian Xu, Lowell L. Wood, Jr., Philip A. Eckhoff, William Gates, Boris Nikolic, Robert S. Langer
  • Publication number: 20150164816
    Abstract: Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.
    Type: Application
    Filed: December 16, 2014
    Publication date: June 18, 2015
    Inventors: Ana Jaklenec, Xian Xu, Lowell L. Wood, JR., Philip A. Eckhoff, William Gates, Boris Nikolic, Robert S. Langer
  • Publication number: 20150165020
    Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.
    Type: Application
    Filed: December 16, 2014
    Publication date: June 18, 2015
    Inventors: Ana Jaklenec, William Gates, Philip A. Eckhoff, Boris Nikolic, Lowell L. Wood, JR., Robert S. Langer
  • Publication number: 20150051169
    Abstract: There is a need for water-based sperm- and egg-friendly vaginal lubricant. We describe novel water-based nature-friendly personal moisturizers and lubricants that relive vaginal dryness. In addition to being non-spermicidal, sperm- and egg-friendly and biological-fluids mimicking, these personal moisturizers and lubricants also enhance sperm survival and motility, promote binding of sperm to eggs and facilitate the process of fertilization. Novel articles, and systems as well as methods of preparation and use of the novel compositions are also provided.
    Type: Application
    Filed: October 29, 2014
    Publication date: February 19, 2015
    Applicant: AQUATROVE BIOSCIENCES, INC.
    Inventors: Vibha Gupta, Vineet Gupta, Boris Nikolic
  • Patent number: 8883417
    Abstract: The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: November 11, 2014
    Assignee: Intelligent Medical Devices, Inc.
    Inventors: Alice A. Jacobs, Boris Nikolic, Vineet Gupta
  • Publication number: 20140147520
    Abstract: There is a need for water-based sperm- and egg-friendly vaginal lubricant. We describe novel water-based nature-friendly personal moisturizers and lubricants that relieve vaginal dryness. In addition to being non-spermicidal, sperm- and egg-friendly and biological-fluids mimicking, these personal moisturizers and lubricants also enhance sperm survival and motility, promote binding of sperm to eggs and facilitate the process of fertilization. Novel articles, and systems as well as methods of preparation and use of the novel compositions are also provided.
    Type: Application
    Filed: January 21, 2014
    Publication date: May 29, 2014
    Applicant: AQUATROVE BIOSCIENCES, INC.
    Inventors: Vibha Gupta, Vineet Gupta, Boris Nikolic
  • Patent number: 8703198
    Abstract: There is a need for water-based sperm- and egg-friendly vaginal lubricant. We describe novel water-based nature-friendly personal moisturizers and lubricants that relive vaginal dryness. In addition to being non-spermicidal, sperm- and egg-friendly and biological-fluids mimicking, these personal moisturizers and lubricants also enhance sperm survival and motility, promote binding of sperm to eggs and facilitate the process of fertilization. Novel articles, and systems as well as methods of preparation and use of the novel compositions are also provided.
    Type: Grant
    Filed: March 1, 2006
    Date of Patent: April 22, 2014
    Assignee: Aquatrove Biosciences
    Inventors: Vibha Gupta, Boris Nikolic, Vineet Gupta
  • Publication number: 20110312531
    Abstract: The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
    Type: Application
    Filed: July 13, 2011
    Publication date: December 22, 2011
    Inventors: Alice A. Jacobs, Vineet Gupta, Boris Nikolic
  • Patent number: 7998679
    Abstract: The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: August 16, 2011
    Assignee: Intelligent Medical Devices, Inc.
    Inventors: Alice A. Jacobs, Boris Nikolic, Vineet Gupta
  • Publication number: 20100233295
    Abstract: This application relates to water-based personal moisturizers and lubricants that relive vaginal dryness. These compositions are non-spermicidal, sperm- and egg-friendly, and in various embodiments may mimic biological fluids, enhance sperm survival and motility, promote binding of sperm to eggs, and/or facilitate the process of fertilization. Related articles, systems, and methods of preparation and use of the compositions are also provided.
    Type: Application
    Filed: February 28, 2007
    Publication date: September 16, 2010
    Inventors: Vibha Gupta, Vineet Gupta, Boris Nikolic
  • Publication number: 20100173797
    Abstract: The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.
    Type: Application
    Filed: November 9, 2009
    Publication date: July 8, 2010
    Inventors: Alice A. Jacobs, Vineet Gupta, Boris Nikolic