Patents by Inventor Boris Nikolic
Boris Nikolic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240181047Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.Type: ApplicationFiled: December 29, 2023Publication date: June 6, 2024Inventors: Ana Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, JR., Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
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Patent number: 11975069Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.Type: GrantFiled: January 7, 2021Date of Patent: May 7, 2024Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, TOKITAE LLCInventors: Ana Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, Jr., Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
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Publication number: 20230372254Abstract: Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.Type: ApplicationFiled: December 16, 2022Publication date: November 23, 2023Inventors: Ana Jaklenec, Xian Xu, Lowell L. Wood, Jr., Philip A. Welkhoff, William Gates, Boris Nikolic, Robert S. Langer
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Patent number: 11541017Abstract: Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.Type: GrantFiled: April 11, 2017Date of Patent: January 3, 2023Assignees: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, TOKITAE LLCInventors: Ana Jaklenec, Xian Xu, Lowell L. Wood, Jr., Philip A. Welkhoff, William Gates, Boris Nikolic, Robert S. Langer
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Publication number: 20210205444Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.Type: ApplicationFiled: January 7, 2021Publication date: July 8, 2021Inventors: Ana Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, JR., Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
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Patent number: 10960073Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.Type: GrantFiled: May 2, 2019Date of Patent: March 30, 2021Assignees: TOKITAE LLC, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Ana Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, Jr., Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
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Publication number: 20190328871Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.Type: ApplicationFiled: May 2, 2019Publication date: October 31, 2019Inventors: Ana Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, JR., Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
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Patent number: 10300136Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.Type: GrantFiled: December 16, 2014Date of Patent: May 28, 2019Assignees: Massachusetts Institute of Technology, Tokitae LLCInventors: Ana Jaklenec, William Gates, Philip A. Welkhoff, Boris Nikolic, Lowell L. Wood, Robert S. Langer, Thanh Duc Nguyen, Stephany Yi Tzeng, James J. Norman, Kevin McHugh
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Publication number: 20170216216Abstract: Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.Type: ApplicationFiled: April 11, 2017Publication date: August 3, 2017Inventors: Ana Jaklenec, Xian Xu, Lowell L. Wood, JR., Philip A. Eckhoff, William Gates, Boris Nikolic, Robert S. Langer
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Patent number: 9649279Abstract: Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.Type: GrantFiled: December 16, 2014Date of Patent: May 16, 2017Assignees: Massachusetts Institute of Technology, Tokitae LLCInventors: Ana Jaklenec, Xian Xu, Lowell L. Wood, Jr., Philip A. Eckhoff, William Gates, Boris Nikolic, Robert S. Langer
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Publication number: 20150164816Abstract: Salt formulations, which are resistant to moisture and cooking conditions, are described herein. The formulations provide particles of micronutrients and vitamins encapsulated within heat resistant pH-sensitive water-insoluble polymers, which are packaged within a salt shell. The pH-sensitive, water-insoluble, thermally stable materials stabilize the micronutrients, particularly at high temperatures, such as during food preparation and cooking, and release the micronutrients at the desired locations such as the stomach, small intestine, etc. Preferred pH-sensitive polymers release at a low pH, less than the pH present in the stomach. The particles can be used to deliver daily-recommended doses of micronutrients simultaneously with salt, eliminating the need for vitamin pills. This is particularly important in populations suffering from severe malnutrition.Type: ApplicationFiled: December 16, 2014Publication date: June 18, 2015Inventors: Ana Jaklenec, Xian Xu, Lowell L. Wood, JR., Philip A. Eckhoff, William Gates, Boris Nikolic, Robert S. Langer
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Publication number: 20150165020Abstract: Emulsion-based and micromolded (“MM”) or three dimensional printed (“3DP”) polymeric formulations for single injection of antigen, preferably releasing at two or more time periods, have been developed. Formulations are preferably formed of biocompatible, biodegradable polymers. Discrete regions encapsulating antigen, alone or in combination with other antigens, adjuvants, stabilizers, and release modifiers, are present in the formulations. Antigen is preferably present in excipient at the time of administration, or on the surface of the formulation, for immediate release, and incorporated within the formulation for release at ten to 45 days after initial release of antigen, optionally at ten to 90 day intervals for release of antigen in one or more additional time periods. Antigen may be stabilized through the use of stabilizing agents such as trehalose glass. In a preferred embodiment for immunization against polio, antigen is released at the time of administration, and two, four and six months thereafter.Type: ApplicationFiled: December 16, 2014Publication date: June 18, 2015Inventors: Ana Jaklenec, William Gates, Philip A. Eckhoff, Boris Nikolic, Lowell L. Wood, JR., Robert S. Langer
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Water-based Personal Moisturizers and Lubricants, in Particular Vaginal Lubricants, and Uses Thereof
Publication number: 20150051169Abstract: There is a need for water-based sperm- and egg-friendly vaginal lubricant. We describe novel water-based nature-friendly personal moisturizers and lubricants that relive vaginal dryness. In addition to being non-spermicidal, sperm- and egg-friendly and biological-fluids mimicking, these personal moisturizers and lubricants also enhance sperm survival and motility, promote binding of sperm to eggs and facilitate the process of fertilization. Novel articles, and systems as well as methods of preparation and use of the novel compositions are also provided.Type: ApplicationFiled: October 29, 2014Publication date: February 19, 2015Applicant: AQUATROVE BIOSCIENCES, INC.Inventors: Vibha Gupta, Vineet Gupta, Boris Nikolic -
Patent number: 8883417Abstract: The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.Type: GrantFiled: July 13, 2011Date of Patent: November 11, 2014Assignee: Intelligent Medical Devices, Inc.Inventors: Alice A. Jacobs, Boris Nikolic, Vineet Gupta
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Water-based Personal Moisturizers and Lubricants, in Particular Vaginal Lubricants, and Uses Thereof
Publication number: 20140147520Abstract: There is a need for water-based sperm- and egg-friendly vaginal lubricant. We describe novel water-based nature-friendly personal moisturizers and lubricants that relieve vaginal dryness. In addition to being non-spermicidal, sperm- and egg-friendly and biological-fluids mimicking, these personal moisturizers and lubricants also enhance sperm survival and motility, promote binding of sperm to eggs and facilitate the process of fertilization. Novel articles, and systems as well as methods of preparation and use of the novel compositions are also provided.Type: ApplicationFiled: January 21, 2014Publication date: May 29, 2014Applicant: AQUATROVE BIOSCIENCES, INC.Inventors: Vibha Gupta, Vineet Gupta, Boris Nikolic -
Water-based personal moisturizers and lubricants, in particular vaginal lubricants, and uses thereof
Patent number: 8703198Abstract: There is a need for water-based sperm- and egg-friendly vaginal lubricant. We describe novel water-based nature-friendly personal moisturizers and lubricants that relive vaginal dryness. In addition to being non-spermicidal, sperm- and egg-friendly and biological-fluids mimicking, these personal moisturizers and lubricants also enhance sperm survival and motility, promote binding of sperm to eggs and facilitate the process of fertilization. Novel articles, and systems as well as methods of preparation and use of the novel compositions are also provided.Type: GrantFiled: March 1, 2006Date of Patent: April 22, 2014Assignee: Aquatrove BiosciencesInventors: Vibha Gupta, Boris Nikolic, Vineet Gupta -
Publication number: 20110312531Abstract: The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.Type: ApplicationFiled: July 13, 2011Publication date: December 22, 2011Inventors: Alice A. Jacobs, Vineet Gupta, Boris Nikolic
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Patent number: 7998679Abstract: The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.Type: GrantFiled: November 9, 2009Date of Patent: August 16, 2011Assignee: Intelligent Medical Devices, Inc.Inventors: Alice A. Jacobs, Boris Nikolic, Vineet Gupta
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Publication number: 20100233295Abstract: This application relates to water-based personal moisturizers and lubricants that relive vaginal dryness. These compositions are non-spermicidal, sperm- and egg-friendly, and in various embodiments may mimic biological fluids, enhance sperm survival and motility, promote binding of sperm to eggs, and/or facilitate the process of fertilization. Related articles, systems, and methods of preparation and use of the compositions are also provided.Type: ApplicationFiled: February 28, 2007Publication date: September 16, 2010Inventors: Vibha Gupta, Vineet Gupta, Boris Nikolic
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Publication number: 20100173797Abstract: The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.Type: ApplicationFiled: November 9, 2009Publication date: July 8, 2010Inventors: Alice A. Jacobs, Vineet Gupta, Boris Nikolic