Patents by Inventor Boris Tefsen

Boris Tefsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • OUTER MEMBRANE VESICLES AND USES THEREOF
    Publication number: 20100047287
    Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally down-regulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
    Type: Application
    Filed: November 3, 2009
    Publication date: February 25, 2010
    Applicants: GLAXOSMITHKLINE S.A., UTRECHT UNIVERSITY
    Inventors: Martine Petronella Bos, Jan Poolman, Boris Tefsen, Johannes Petrus Maria Tommassen
  • Outer membrane vesicles and uses thereof
    Patent number: 7628995
    Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: December 8, 2009
    Assignees: GlaxoSmithKline Biologicals S.A., University of Utrecht
    Inventors: Martine Petronella Bos, Jan Poolman, Boris Tefsen, Johannes Petrus Maria Tommassen
  • Vaccine
    Publication number: 20070031449
    Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
    Type: Application
    Filed: December 21, 2004
    Publication date: February 8, 2007
    Inventors: Martine Bos, Jan Poolman, Boris Tefsen, Johannes Tommassen