Abstract: The present invention provides the sequence of a protein capable of acting as an angiostatin receptor as well as the nucleic acid sequence thereof. The invention also relates to the use thereof in screening methods, wherein novel substances are created exhibiting the same advantageous anti-angiogenic properties as angiostatin.

Abstract: The present invention provides the sequence of a protein capable of acting as an angiostatin receptor as well as the nucleic acid sequence thereof. The invention also relates to the use thereof in screening methods, wherein novel substances are created exhibiting the same advantageous anti-angiogenic properties as angiostatin.

Abstract: A method and apparatus to achieve relatively high quality audio data compression/decompression, while achieving relatively low bit rates (e.g., high compression ratios). According to one aspect of the invention, a residual signal is subband decomposed and adaptively quantized and encoded to capture frequency information that may provide higher quality compression and decompression relative to transform encoding techniques. According to a second aspect of the invention, an input audio signal is compared to an encoded signal based on the input audio signal to detect and reduce, as necessary, distortion in the encoded signal or portions thereof.

Abstract: The present disclosure provides a method and apparatus for using frequency domain data, such as S-parameters, in a time-based simulator. S-parameters are either input to the simulator, or are empirically measured, at selected frequencies. Preferably, the selected frequencies are related to one another by a logarithmic scale, providing for determination of a system transfer function which is accurate across a very wide range of frequencies, from near zero hertz, to frequencies on the order of a hundred gigahertz. The transfer function preferably takes the form of a fitted polynomial, obtained using FDSI techniques. In addition, recursive convolution may be employed to operate in the time domain on inverse Laplace Transforms of the fitted transfer function and time-domain simulator test signals.

Abstract: A method and apparatus for compression and decompression of an audio signal. In encoding an input audio signal, at least a portion of the audio signal is transformed into a set of coefficients. A set of binary vectors associated with the set of coefficients are generated for digitizing the transformed audio signal using a fixed rate adaptive quantization. Information based on the set of binary vectors is combinatorially encoded and output as a bit stream of encoded audio data. The encoded audio data may be stored, transmitted, and/or decoded.

Abstract: A method for simulating the response of a circuit to one or more stimulating signals using a digital computer. The circuit is represented by N nodes. Each node is connected to one or more devices. The nodes are held at a set of potentials represented by ##EQU1## where X.sub.n,-h =X.sub.n,h.sup.*, n runs from 1 to N, and H is an integer greater than 0. The method of the present invention determines the values of the X.sub.n,h by iteratively computing a new estimate for X=?X.sub.10, . . . , X.sub.1H, X.sub.20, . . . , X.sub.2H, . . . , X.sub.N0, . . . X.sub.NH ! from a previous estimate for X based on F.sub.nh, for n from 1 to N and h from 0 to H. Here, F.sub.nh is the net current flowing into node n at frequency .omega..sub.h. The net current at node n includes a non-linear resistive component r.sub.n (x(t)) and a non-linear charge storage component q.sub.n (x(t)), where x(t) is a vector having components x.sub.n (t). The method of the present invention defines a set of mapped frequencies {.omega..sub.

Abstract: A method for simulating the response of a circuit to one or more stimulating signals using a digital computer. The circuit is represented by N nodes, where N is an integer greater than 1. Each of the nodes is connected to one or more devices, each device being represented by a computer routine that provides the current sourced by that device at each frequency, .omega..sub.h, when the nodes are held at a set of potentials represented by ##EQU1## where X.sub.n,-h =X*.sub.n,h,n runs from 1 to N, and H is an integer greater than 0. The method determines the values of the X.sub.n,h by iteratively computing a new estimate for X=[X.sub.10, . . . ,X.sub.1H,X.sub.20, . . . ,X.sub.2H, . . . ,X.sub.N0, . . . X.sub.NH ] from a previous estimate for X. The estimates for X are based on the values of F.sub.nh, for n from 1 to N and h from 0 to H, where F.sub.nh is the net current flowing into node n for frequency .omega..sub.h. Each iteration includes four steps.