Patents by Inventor Borislav Borisov Trifonov

Borislav Borisov Trifonov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antitumor agents isolated from intestinal mucosa, a method for their isolation and their application
    Patent number: 6015878
    Abstract: This invention provides a method for isolating antitumor agents, inhibiting enterocytogenins, from pig intestinal mucosa. It further provides the antitumor agents, which are nucleopeptides. Additionally the invention provides methods for suppressing the growth of certain tumor cells comprising administering an inhibiting enterocytogenin to tumor cells.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: January 18, 2000
    Assignee: Alexandrov, Christo Alexandrov
    Inventors: Borislav Borisov Trifonov, Jeorge Konstantinov Roussev, Nikola Atanassov Boshev
  • Stimulating ENTEROGENIN compositions and methods for their isolation and use
    Patent number: 5948442
    Abstract: This patent relates to the obtaining of two pharmaceutical forms--pulvis and ampules of the veterinary medical preparation "Enterogenin". The bioactive ingredient of the preparation is isolated by fractionation of pig small intestinal mucosa cell, extraction with acetic acid, sedimentation with ethyl alcohol, ion-exchange chromatography and diaflo ultrafiltration in the range of 0.5-2 kDa. The bioactivity of the preparation is related to two nucleopeptides: guanosine tripeptide and adenosine heptapeptide. The basic criterion for the biological action of "Enterogenin" pulvis and ampules is the activation of biosynthesis of nucleic acids and specific proteins in the muscles, liver, intestines and spleen.
    Type: Grant
    Filed: March 17, 1997
    Date of Patent: September 7, 1999
    Assignee: Christo Alexandrov Alexandrov
    Inventors: Borislav Borisov Trifonov, Jeorge Konstantinov Roussev, Nikola Atanassov Boshev, Metodi Stefanov Petrov