Abstract: The present disclosure relates to compounds having the structure of Formula (I) that serve as degraders (and/or inhibitors) of Bruton's tyrosine kinase (BTK). In the present disclosure, the said compounds, which contain a target protein (BTK) binding moiety and a E3 ubiquitin ligase (CRBN) binding moiety, are directed to bind to both the BTK and CRBN, such that the BTK is placed in close proximity to the E3 ligase to mediate ubiquitylation of the target protein followed by degradation of the target protein by the proteasome. The present disclosure provides methods for synthesizing the herein disclosed said compounds, and their pharmacological activities associated with degradation or inhibition of the target protein.

Abstract: The present disclosure relates to bifunctional compounds that serve as degraders (and/or inhibitors) of Bruton's tyrosine kinase (BTK). In the present disclosure, the bifunctional compounds, which contain a target protein (BTK) binding moiety and a E3 ubiquitin ligase (CRBN) binding moiety, are directed to bind to both the BTK and CRBN, such that the BTK is placed in close proximity to the E3 ligase to mediate ubiquitylation of the target protein followed by degradation of the target protein by the proteasome. The present disclosure provides methods for synthesizing the herein disclosed bifunctional compounds, and their pharmacological activities associated with degradation or inhibition of the target protein.

Abstract: The present disclosure relates to bifunctional compounds that serve as degraders (and/or inhibitors) of the estrogen receptor (target protein). In the present disclosure, the bifunctional compounds, which contain a target protein (estrogen receptor) binding moiety and a E3 ubiquitin ligase (CRBN) binding moiety, are directed to bind to both estrogen receptor and CRBN, such that the ER is placed in close proximity to the E3 ligase to mediate ubiquitylation of the target protein followed by degradation of the target protein by the proteasome. The present disclosure provides methods for synthesizing the herein disclosed bifunctional compounds, and their pharmacological activities associated with degradation or inhibition of the target protein. Further, the present disclosure teaches the utilization of such compounds in a treatment for proliferative diseases, including cancer, particularly breast cancer, and especially ER+ breast cancer.

Abstract: The present disclosure relates to compounds that act as antagonists via binding to the ER ligand binding domain non-covalently or covalently, or act as both antagonists and ER protein degraders, and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for proliferative diseases, including cancer, particularly breast cancer, and especially ER+ breast cancer.

Abstract: An RFIC controller configured for executing multiple tasks. A serial interface is included having a serial bus for receiving a data stream having control bits and data bits. One or more registers are coupled to the serial bus for storing the control bits and data bits as they are received. Control circuitry is also included. The data stream is formatted such that the control bits are received before the data bits, the control bits specifying an operation. The control circuitry is configured to examine the control bits as they are received to determine the operation specified by the control bits before the data bits are received. A task corresponding to the operation specified by the control bits is then initiated before the data bits are received.

Abstract: An RFIC controller configured for executing multiple tasks. A serial interface is included having a serial bus for receiving a data stream having control bits and data bits. One or more registers are coupled to the serial bus for storing the control bits and data bits as they are received. Control circuitry is also included. The data stream is formatted such that the control bits are received before the data bits, the control bits specifying an operation. The control circuitry is configured to examine the control bits as they are received to determine the operation specified by the control bits before the data bits are received. A task corresponding to the operation specified by the control bits is then initiated before the data bits are received.