Patents by Inventor Borut Furlan

Borut Furlan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF PERINDOPRIL ERBUMINE
    Publication number: 20100016614
    Abstract: The present invention relates to a new process for the preparation of pure perindopril erbumine. The present invention also relates to a new process for the preparation of crystalline form D of perindopril erbumine.
    Type: Application
    Filed: August 10, 2006
    Publication date: January 21, 2010
    Applicant: LEK PHARMACEUTICALS D.D
    Inventors: Zoran Ham, Borut Furlan
  • Preparation of R-5- (2-(2-Ethoxyphenoxyetylamino) -2-Methoxybenzen-Sulphonamide Hydrochloride of High Chemical
    Publication number: 20080033207
    Abstract: In the present invention, the process for the preparation of tamsulosin hydrochloride and subsequent purification with thermal crystallisation to provide essentially pure tamsulosin hydrochloride is disclosed.
    Type: Application
    Filed: December 27, 2004
    Publication date: February 7, 2008
    Inventors: Borut Furlan, Anton Copar
  • High purity amlodipine benzenesulfonate and a process for its preparation
    Patent number: 7153970
    Abstract: 3-ethyl 5-methyl (+/?) 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate benzenesulfonate, containing overall impurities of significantly less than 0.3% is disclosed, as well as process for its preparation, according to which substance of 3-ethyl 5-methyl (+/?) 2-[2-(N-trialkylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate is converted with benzenesulfonic acid in ethanol solution, at a temperature between 20° C. and reflux temperature, followed by isolation and purification of 3-ethyl 5-methyl (+/?) 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate benzenesulfonate. Amlodipine benzenesulfonate is useful as an antiishemic and antihypertensive agent.
    Type: Grant
    Filed: July 5, 2002
    Date of Patent: December 26, 2006
    Assignee: Lek Pharmaceuticals d.d.
    Inventors: Borut Furlan, Marijan Resnik
  • High purity amlodipine benzenesulfonate and a process for its preparation
    Publication number: 20040176606
    Abstract: 3-ethyl 5-methyl (+/−) 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate benzenesulfonate, containing overall impurities of significantly less than 0.3% is disclosed, as well as process for its preparation, according to which substance of 3-ethyl 5-methyl (+/−) 2-[2-(N-trialkylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate is converted with benzenesulfonic acid in ethanol solution, at a temperature between 20° C. and reflux temperature, followed by isolation and purification of 3-ethyl 5-methyl (+/−) 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate benzenesulfonate. Amlodipine benzenesulfonate is useful as an antiishemic and antihypertensive agent.
    Type: Application
    Filed: December 23, 2003
    Publication date: September 9, 2004
    Inventors: Borut Furlan, Marijan Resnik
  • Process for the preparation of amlodipine benzenesulphonate
    Patent number: 5438145
    Abstract: There is disclosed a process for the preparation of 3-ethyl 5-methyl (.+-.) 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyri dine-dicarboxylate monobenzenesulphonate (amlodipine benzenesulphonate) of formula ##STR1## wherein 3-ethyl 5-methyl (.+-.) 2-[2-(N-tritylamino)-ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl -3,5-pyridinecarboxylate is reacted with benzenesulphonic acid in a methanolic or an aqueous methanolic medium at a temperature from 20.degree. C. to the reflux temperature and the title compound is isolated and purified.Amlodipine benzene sulphonate is a valuable anti-ischaemic and anti-hypertensive agent.
    Type: Grant
    Filed: August 25, 1994
    Date of Patent: August 1, 1995
    Assignee: LEK, tovarna farmecevtskih in kemicnih izdelkov
    Inventors: Borut Furlan, Anton Copar, Alenka Jeriha
  • 3-ethyl 5-methyl(.+-.)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-d ihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate
    Patent number: 5389654
    Abstract: There is disclosed a process for the preparation of 3-ethyl 5-methyl (.+-.) 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyri dine-dicarboxylate monobenzenesulphonate (amlodipine benzenesulphonate) of formula ##STR1## wherein 3-ethyl 5-methyl (.+-.) 2-[2-(N-tritylamino)-ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl -3,5-pyridinedicarboxylate is reacted with benzenesulphonic acid in a methanolic or an aqueous methanolic medium at a temperature from 20.degree. C. to the reflux temperature and the title compound is isolated and purified.Amlodipine benzene sulphonate is a valuable anti-ischaemic and anti-hypertensive agent.
    Type: Grant
    Filed: November 10, 1993
    Date of Patent: February 14, 1995
    Assignee: LEK, tovarna, farmacevtskih in Kemicnih . . .
    Inventors: Borut Furlan, Anton Copar, Alenka Jeriha