Patents by Inventor Bosco A. D'sa

Bosco A. D'sa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of CCR5 receptor antagonists
    Patent number: 7728135
    Abstract: The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: June 1, 2010
    Assignee: Schering Corporation
    Inventors: Xiongwei Shi, Man Zhu, William Leong, Vilas Dahanukar, Ilia A. Zavialov, Cecelia Proietti, Shannon Zhao, Hong-Chang Lee, Yi Liu, Hoa N. Nguyen, Wenxue Wu, Bosco D'Sa, Feng Liang, Loc Thanh Tran
  • SYNTHESIS OF CCR5 RECEPTOR ANTAGONISTS
    Publication number: 20100036125
    Abstract: The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.
    Type: Application
    Filed: October 16, 2009
    Publication date: February 11, 2010
    Inventors: Xiongwei Shi, Man Zhu, William Leong, Vilas Dahanukar, Ilia A. Zavialov, Cecilia Proietti, Shannon Zhao, Hong-Chang Lee, Yi Liu, Hoa N. Nguyen, Wenxue Wu, Bosco D'Sa, Feng Liang, Loc Thanh Tran
  • Preparation of pharmaceutical salts of piperazine compounds
    Patent number: 7521452
    Abstract: The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative choice of an acid and a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance of a rotamer.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: April 21, 2009
    Assignee: Schering Corporation
    Inventors: Wenxue Wu, Loc Thanh Tran, Bosco D'Sa, Feng Liang, William Leong, Hong-Chang Lee, Kevin Klopfer, Vijay Sabesen
  • PREPARATION OF PHARMACEUTICAL SALTS OF PIPERAZINE COMPOUNDS
    Publication number: 20090093496
    Abstract: The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative choice of an acid and a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance of a rotamer.
    Type: Application
    Filed: December 10, 2008
    Publication date: April 9, 2009
    Inventors: Wenxue Wu, Loc Thanh Tran, Bosco D'Sa, Feng Liang, William Leong, Hong-Chang Lee, Kevin Klopfer, Vijay Sabesan
  • Synthesis of CCR5 antagonists
    Publication number: 20060258863
    Abstract: The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.
    Type: Application
    Filed: January 5, 2006
    Publication date: November 16, 2006
    Inventors: Xiongwei Shi, Man Zhu, William Leong, Vilas Dahanukar, Ilia Zavialov, Cecilia Proletei, Shannon Zhao, Hong-Chang Lee, Yi Liu, Hoa Nguyen, Wenxue Wu, Bosco D'Sa, Feng Liang, Loc Tran
  • Preparation of pharmaceutical salts of piperazine compounds
    Publication number: 20060241295
    Abstract: The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative choice of an acid and a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance of a rotamer.
    Type: Application
    Filed: January 5, 2006
    Publication date: October 26, 2006
    Inventors: Wenxue Wu, Loc Tran, Bosco D'Sa, Feng Liang, William Leong, Hong-Chang Lee, Kevin Klopfer, Vijay Sabesen
  • Synthesis of piperidine and piperazine compounds as CCR5 antagonists
    Patent number: 6992189
    Abstract: In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: January 31, 2006
    Assignee: Schering Corporation
    Inventors: William Leong, Minzhang Chen, Bosco A. D'sa, Man Zhu, Tong Xiao, Xiongwei Shi, Suhan Tang, Dinesh Gala, Andrew J. Goodman, Christopher M. Nielsen, Gary M. Lee, Juan A. Gamboa, Andrew D. Jones
  • Preparation of rotamer mixtures of pharmaceutical salts
    Patent number: 6936718
    Abstract: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of specific, preferred rotamer or rotameric pair of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing desired rotamers of pharmaceutically useful salts.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: August 30, 2005
    Assignee: Schering Corporation
    Inventors: Minzhang Chen, Bosco D'sa, William Leong, Suhan Tang
  • Synthesis of piperidine and piperazine compounds as CCR5 antagonists
    Publication number: 20050187248
    Abstract: In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV:
    Type: Application
    Filed: March 24, 2005
    Publication date: August 25, 2005
    Inventors: William Leong, Minzhang Chen, Bosco D'sa, Man Zhu, Tong Xiao, Xiongwei Shi, Suhan Tang, Dinesh Gala, Andrew Goodman, Christopher Nielsen, Gary Lee, Juan Gamboa, Andrew Jones
  • Synthesis of piperidine and piperazine compounds as CCR5 antagonists
    Publication number: 20040024217
    Abstract: In its several embodiments, this invention discloses novel processes to prepare the compounds of formula II and formula IV: 1
    Type: Application
    Filed: March 27, 2003
    Publication date: February 5, 2004
    Applicant: Schering Corporation
    Inventors: William Leong, Minzhang Chen, Bosco A. D'sa, Man Zhu, Tong Xiao, Xiongwei Shi, Suhan Tang, Dinesh Gala, Andrew J. Goodman, Christopher M. Nielsen, Gary M. Lee, Juan A. Gamboa, Andrew D. Jones
  • Preparation of pharmaceutical salts
    Publication number: 20030139446
    Abstract: In one embodiment, the present invention discloses a process to directly prepare an unequal ratio of specific, preferred rotamer or rotameric pair of an acid salt from a basic compound, by creative choice of a solvent medium. The process is particularly useful in preparing desired rotamers of pharmaceutically useful salts.
    Type: Application
    Filed: November 26, 2002
    Publication date: July 24, 2003
    Applicant: Schering Corporation
    Inventors: Minzhang Chen, Bosco D'sa, William Leong, Suhan Tang