Patents by Inventor Bosiljka Tasic

Bosiljka Tasic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240254514
    Abstract: Artificial expression constructs for modulating gene expression in targeted central nervous system cell types are described. The artificial expression constructs can be used to express synthetic genes or modify gene expression in GABAergic or glutamatergic neurons within the thalamus. In some cases, the artificial constructs can also be used to express synthetic genes or modify gene expression in neurons within the thalamus as well as a secondary cell type.
    Type: Application
    Filed: May 20, 2022
    Publication date: August 1, 2024
    Applicant: ALLEN INSTITUTE
    Inventors: Tanya Daigle, Edward Sebastian Lein, Boaz P. Levi, John K. Mich, Amanda Mitchell, Bosiljka Tasic, Jonathan Ting, Natalie Weed, Hongkui Zeng
  • Publication number: 20240182923
    Abstract: Artificial expression constructs for modulating gene expression in targeted central nervous system cell types are described. The artificial expression constructs can be used to express synthetic genes or modify gene expression in claustrum neurons including L6 IT Car3 neurons.
    Type: Application
    Filed: March 30, 2022
    Publication date: June 6, 2024
    Applicant: Allen Institute
    Inventors: Tanya Daigle, Lucas T. Graybuck, Adriana Estela Sedeño Cortés, Bosiljka Tasic, Jonathan Ting
  • Publication number: 20240018543
    Abstract: Artificial expression constructs for modulating gene expression in targeted central nervous system cell types are described. The artificial expression constructs can be used to express synthetic genes or modify gene expression in chandelier cells. Chandelier cells are a subtype of GABAergic interneurons that that have been implicated in disorders such as epilepsy and schizophrenia.
    Type: Application
    Filed: November 10, 2021
    Publication date: January 18, 2024
    Applicant: Allen Institute
    Inventors: Tanya Daigle, Lucas T. Graybuck, Brian Edward Kalmbach, Edward Sebastian Lein, John K. Mich, Boaz P. Levi, Adriana Estela Sedeño Cortés, Bosiljka Tasic, Jonathan Ting, Hongkui Zeng
  • Publication number: 20230302158
    Abstract: Artificial expression constructs for modulating gene expression in striatal neurons are described. The artificial expression constructs can be used to express heterologous genes in striatal neurons including in striatal medium spiny neuron-pan, striatal medium spiny neuron-indirect pathway, striatal medium spiny neuron-direct pathway, striatal interneuron-cholinergic, and Drd3+ medium spiny neurons in olfactory tubercle. The artificial expression constructs can be used for many purposes, including to research and treat movement disorders such as Parkinson's disease and Huntington's disease.
    Type: Application
    Filed: August 13, 2021
    Publication date: September 28, 2023
    Applicant: Allen Institute
    Inventors: Tanya Daigle, Edward Sebastian Lein, Boaz P. Levi, John K. Mich, Bosiljka Tasic, Jonathan Ting, Hongkui Zeng
  • Publication number: 20230212608
    Abstract: Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in inhibitory neocortical GABAergic neurons including somatostatin GABAergic neurons, parvalbumin GABAergic neurons, vasointestinal peptide GABAergic neurons, Lamp5 GABAergic neurons, and in some instances astrocytes.
    Type: Application
    Filed: June 4, 2021
    Publication date: July 6, 2023
    Applicant: Allen Institute
    Inventors: Tanya Daigle, Lucas T. Graybuck, Edward Sebastian Lein, Boaz P. Levi, John K. Mich, Adriana Estela Sedeño Cortés, Bosiljka Tasic, Jonathan Ting, Miranda Walker, Hongkui Zeng
  • Publication number: 20230159952
    Abstract: Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. Particularly, the artificial expression constructs can be used to selectively express synthetic genes and/or modify gene expression in neocortical glutamatergic layer 5 neurons, such as glutamatergic layer 5 extratelencephalic-projecting (L5 ET) neurons.
    Type: Application
    Filed: April 21, 2021
    Publication date: May 25, 2023
    Applicant: ALLEN INSTITUTE
    Inventors: Tanya Daigle, Lucas T. Graybuck, Brian Edward Kalmbach, Edward Sebastian Lein, Boaz P. Levi, John K. Mich, Adriana Estela Sedeño Cortés, Bosiljka Tasic, Jonathan Ting, Hongkui Zeng
  • Publication number: 20230117172
    Abstract: Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in astrocytes, oligodendrocytes, microglia, pericytes, SMC, or endothelial cells.
    Type: Application
    Filed: March 26, 2021
    Publication date: April 20, 2023
    Applicant: ALLEN INSTITUTE
    Inventors: Jonathan Ting, Bosiljka Tasic, Boaz P. Levi, Tanya Daigle, Lucas T. Graybuck, Edward Sebastian Lein, John K. Mich, Adriana Estela Sedeño Cortés, Hongkui Zeng
  • Publication number: 20220249703
    Abstract: Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in GABAergic neurons generally; and/or GABAergic neuron cell types such as lysosomal associated membrane protein 5 (Lamp5) neurons; vasoactive intestinal polypeptide-expressing (Vip) neurons; somatostatin (Sst) neurons; and/or parvalbumin (Pvalb) neuron cell types. Certain artificial expression constructs additionally drive selective gene expression in Layer 4 and/or layer 5 intratelencephalic (IT) neurons, deep cerebellar nuclear neurons or cerebellar Purkinje cells.
    Type: Application
    Filed: February 14, 2020
    Publication date: August 11, 2022
    Applicant: Allen Institute
    Inventors: Jonathan Ting, Boaz P. Levi, Bosiljka Tasic, John K. Mich, Erik Hess, Edward Sebastian Lein, Lucas T. Graybuck, Tanya Daigle, Hongkui Zeng
  • Publication number: 20210395780
    Abstract: Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in excitatory cortical neurons, such as primarily within cortical layers 2/3, 4, 5, and 6 and including those with extratelencephalic (ET) projections, intratelencephalic (IT) projections, and pyramidal tract (PT) projections, among others.
    Type: Application
    Filed: November 5, 2019
    Publication date: December 23, 2021
    Applicant: Allen Institute
    Inventors: Lucas T. Graybuck, Bosiljka Tasic, Tanya Daigle, Jonathan Ting, Hongkui Zeng, Brian Edward Kalmbach, John K. Mich, Erik Hess, Edward Sebastian Lein, Boaz P. Levi
  • Patent number: 9932607
    Abstract: Methods for inserting a polynucleotide sequence into the genome of a human cell are provided. The present methods result in insertion of a polynucleotide sequence of interest into the H11 locus in the genome of a human cell. Also provided are nucleic acids that include sequences for integrating a polynucleotide sequence of interest into the H11 locus in the genome of a human cell. A transgenic human cell including site specific recombination sites at the H11 locus is also disclosed.
    Type: Grant
    Filed: November 12, 2014
    Date of Patent: April 3, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Michele Pamela Calos, Ruby Yanru Tsai, Fangfang Zhu, Matthew Gamboa, Alfonso P. Farruggio, Simon Hippenmeyer, Bosiljka Tasic, Birgitt Schüle
  • Patent number: 9125385
    Abstract: The present disclosure provides a method of making a mammal (e.g., a rodent, such as a mouse) by integrating an intact polynucleotide sequence into a specific genomic locus of the mammal to result in a transgenic mammal. A transgenic mammal made by the methods of the present disclosure would contain a known copy number (e.g., one) of the inserted polynucleotide sequence at a predetermined location. The method involves introducing a site-specific recombinase and a targeting construct, containing a first recombination site and the polynucleotide sequence of interest, into the mammalian cell. The genome of the cell contains a second recombination site and recombination between the first and second recombination sites is facilitated by the site-specific, uni-directional recombinase. The result of the recombination is site-specific integration of the polynucleotide sequence of interest in the genome of the mammal. This inserted sequence is then also transmitted to the progeny of the mammal.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: September 8, 2015
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Liqun Luo, Ruby Yanru Tsai, Bosiljka Tasic, Simon Hippenmeyer, Hui Zong
  • Publication number: 20150140665
    Abstract: Methods for inserting a polynucleotide sequence into the genome of a human cell are provided. The present methods result in insertion of a polynucleotide sequence of interest into the H11 locus in the genome of a human cell. Also provided are nucleic acids that include sequences for integrating a polynucleotide sequence of interest into the H11 locus in the genome of a human cell. A transgenic human cell including site specific recombination sites at the H11 locus is also disclosed.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 21, 2015
    Inventors: Michele Pamela Calos, Ruby Yanru Tsai, Fangfang Zhu, Matthew Gamboa, Alfonso P. Farruggio, Simon Hippenmeyer, Bosiljka Tasic, Birgitt Schüle
  • Publication number: 20120124686
    Abstract: The present disclosure provides a method of making a mammal (e.g., a rodent, such as a mouse) by integrating an intact polynucleotide sequence into a specific genomic locus of the mammal to result in a transgenic mammal. A transgenic mammal made by the methods of the present disclosure would contain a known copy number (e.g., one) of the inserted polynucleotide sequence at a predetermined location. The method involves introducing a site-specific recombinase and a targeting construct, containing a first recombination site and the polynucleotide sequence of interest, into the mammalian cell. The genome of the cell contains a second recombination site and recombination between the first and second recombination sites is facilitated by the site-specific, uni-directional recombinase. The result of the recombination is site-specific integration of the polynucleotide sequence of interest in the genome of the mammal. This inserted sequence is then also transmitted to the progeny of the mammal.
    Type: Application
    Filed: November 10, 2011
    Publication date: May 17, 2012
    Inventors: Liqun Luo, Ruby Yanru Tsai, Bosiljka Tasic, Simon Hippenmeyer, Hui Zong
  • Publication number: 20110277050
    Abstract: Embodiments of the present invention describe a novel and versatile inducible binary expression system (the ‘Q system’) and methods for controlling transgene expression in vitro and in vivo, for lineage tracing, for genetic mosaic analysis and for determining gene function.
    Type: Application
    Filed: March 11, 2011
    Publication date: November 10, 2011
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Liqun Luo, Christopher Potter, Bosiljka Tasic