Patents by Inventor Boska Hrvacic

Boska Hrvacic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy
    Patent number: 7928078
    Abstract: The present invention relates to novel compounds represented by the structure I and pharmaceutical preparations thereof for the treatment of inflammatory diseases in humans and animals.
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: April 19, 2011
    Assignee: GlaxoSmithKline Istrazivacki Centar Zagreb D.O.O.
    Inventors: Mladen Mercep, Milan Mesic, Linda Tomaskovic, Marijana Komac, Boska Hrvacic, Stribor Markovic
  • Conjugates of Immune Cell Specific Macrolide Compounds with Anti-Inflammatory Compounds for Improved Cellular Targeting of Anti-Inflammatory Therapy
    Publication number: 20090105163
    Abstract: The present invention relates to novel compounds represented by the structure I and pharmaceutical preparations thereof for the treatment of inflammatory diseases in humans and animals.
    Type: Application
    Filed: September 16, 2008
    Publication date: April 23, 2009
    Applicant: GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.
    Inventors: Mladen MERCEP, Milan MESIC, Linda TOMASKOVIC, Marijana KOMAC, Boska HRVACIC, Stribor MARKOVIC
  • Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy
    Patent number: 7446097
    Abstract: The present invention relates to novel compounds represented by the structure I and pharmaceutical preparations thereof for the treatment of inflammatory diseases in humans and animals.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: November 4, 2008
    Assignee: Glaxosmithkline Istrazivacki Centar Zagreb D.O.O
    Inventors: Mladen Mercep, Milan Mesic, Linda Tomaskovic, Marijana Komac, Boska Hrvacic, Stribor Markovic
  • Macrolides With Anti-Inflammatory Activity
    Publication number: 20080221046
    Abstract: The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the 4? position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-?, IL-1, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.
    Type: Application
    Filed: January 13, 2006
    Publication date: September 11, 2008
    Inventors: Ognjen Culic, Martina Bosnar, Nikola Marjanovic, Dubravko Jelic, Sulejman Alihodzic, Vanja Vela, Zorica Marusic-Istuk, Vesna Erakovic, Berislav Bosnjak, Boska Hrvacic, Marija Tomaskovic, Vanesa Munic, Vanesa Ivetic, Antun Hutinec, Goran Kragol, Marija Leljak
  • Bis-(Coumarin) Compounds With Anti-Inflammatory Activity
    Publication number: 20080153872
    Abstract: Certain bis-(coumarin) compounds as well as the products of their intramolecular cyclization including pharmaceutically acceptable salts, hydrates, solvates, clathrates, prodrugs, tautomers and stereoisomers thereof are disclosed. Certain processes and intermediates for the preparation of certain bis-(coumarin) compounds, as well as for the use of these compounds as therapeutically active agents in the prophylaxis and treatment of asthma and other inflammatory diseases and conditions in mammals, especially humans are also disclosed.
    Type: Application
    Filed: January 13, 2006
    Publication date: June 26, 2008
    Inventors: Mladen Mercep, Ivica Malnar, Boska Hrvacic, Stribor Markovic, Anita Filipovic Sucic, Berislav Bosnjak, Andreja Cempuh Klonkay, Renata Rupcic, Antun Hutinec, Ivaylo Jivkov Elenkov, Milan Mesic
  • Substituted furochromenes, preparation thereof and their antiinflammatory action
    Patent number: 7384975
    Abstract: The invention relates to novel compounds of the formula (I) including all their tautomers, to pharmaceutically acceptable salts and solvates thereof, to processes and reactive intermediates for the preparation thereof, and to processes and reactive intermediates for the preparation of the compounds of the formula (II) including all their stereoisomers and tautomers to the use of the compounds of the formula (II) as suitable precursors for the preparation of the compounds of the formula (I) as well as to use of the compounds of the formula (I) and of the compounds of the formula (II) as therapeutically active agents in the prophylaxis and treatment of asthma and other inflammatory diesases and conditions in humans.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: June 10, 2008
    Assignee: GlaxoSmithKline Istrazivacki Centar Zagreb d.o.o.
    Inventors: Mladen Mercep, Milan Mesic, Boska Hrvacic, Ivaylo Jivkov Elenkov, Ivica Malnar, Stribor Markovic, Lidija Simicic, Andreja Cempuh Klonkay, Anita Filipovic
  • Substituted furochromene compounds of antiinflammatory action
    Patent number: 7208518
    Abstract: The present invention relates to novel compounds of the formula (I) including all stereoisomers and tautomers thereof, to the pharmaceutically acceptable salts and solvates thereof, to the processes and reactive intermediates for their preparation and to their use in the prophylaxis and treatment of asthma and other inflammatory diseases and/or conditions in humans.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: April 24, 2007
    Assignee: GlaxoSmithKline Istrazivacki Centar Zagreb D.O.O.
    Inventors: Mladen Mercep, Milan Mesic, Boska Hrvacic, Ivaylo Jivkov Elenkov, Ivica Malnar, Stribor Markovic, Lidija Simicic, Andreja Cempuh Klonkay, Anita Filipovic
  • USE OF 2-THIA-DIBENZO[E,H]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
    Publication number: 20060241099
    Abstract: The present invention relates to the use of compounds from the group of 2-thia-dibenzo[e,h]azulenes and of their pharmacologically acceptable salts and solvates for the manufacture of a pharmaceutical formulation for the treatment and prevention of diseases, damages and disorders of the central nervous system (CNS) caused by disorders of the neurochemical equilibrium of biogenic amines or other neurotransmitters.
    Type: Application
    Filed: May 2, 2006
    Publication date: October 26, 2006
    Applicant: Pliva-Istrazivacki Institut d.o.o.
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Ivana Ozimec Landak, Boska Hrvacic, Barbara Stanic
  • Substituted furochromenes, preparation thereof and their antiinflammatory action
    Publication number: 20060148889
    Abstract: The invention relates to novel compounds of the formula (I) including all their tautomers, to pharmaceutically acceptable salts and solvates thereof, to processes and reactive intermediates for the preparation thereof, and to processes and reactive intermediates for the preparation of the compounds of the formula (II) including all their stereoisomers and tautomers to the use of the compounds of the formula (II) as suitable precursors for the preparation of the compounds of the formula (I) as well as to use of the compounds of the formula (I) and of the compounds of the formula (II) as therapeutically active agents in the prophylaxis and treatment of asthma and other inflammatory diesases and conditions in humans.
    Type: Application
    Filed: January 20, 2006
    Publication date: July 6, 2006
    Applicant: Pliva-Istrazivacki Institut d.o.o.
    Inventors: Mladen Mercep, Milan Mesic, Boska Hrvacic, Ivaylo Jivkov Elenkov, Ivica Malnar, Stribor Markovic, Lidija Simicic, Andreja Cempuh Klonkay, Anita Filipovic
  • Substituted furochromene compounds of antiinflammatory action
    Publication number: 20060148890
    Abstract: The present invention relates to novel compounds of the formula (I) including all stereoisomers and tautomers thereof, to the pharmaceutically acceptable salts and solvates thereof, to the processes and reactive intermediates for their preparation and to their use in the prophylaxis and treatment of asthma and other inflammatory diesases and/or conditions in humans.
    Type: Application
    Filed: January 23, 2006
    Publication date: July 6, 2006
    Applicant: Pliva-lstrazivacki Institut d.o.o.
    Inventors: Mladen Mercep, Milan Mesic, Boska Hrvacic, Ivajlo Elenkov, Ivica Malnar, Stribor Markovic, Lidija Simicic, Andreja Cempuh Klonkay, Anita Filipovic
  • Thienodibenzoazulene compounds as tumor necrosis factor inhibitors
    Publication number: 20050171091
    Abstract: The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-?) and interleukine 1 (IL-1) in mammals at all diseases and conditions where these mediators are excessively secreted. The compounds of the present invention also demonstrate an analgetic action and can be used to relieve pain.
    Type: Application
    Filed: March 25, 2005
    Publication date: August 4, 2005
    Applicant: Pliva d.d.
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Zeljko Zupanovic, Boska Hrvacic
  • Thienodibenzoazulene compounds as tumor necrosis factor inhibitors
    Patent number: 6897211
    Abstract: The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-?) and interleukine 1 (IL-1) in mammals at all diseases and conditions where these mediators are excessively secreted. The compounds of the present invention also demonstrate an analgetic action and can be used to relieve pain.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: May 24, 2005
    Assignee: Pliva-Istrazivacki Institut d.o.o.
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Zeljko Zupanovic, Boska Hrvacic
  • Compounds with anti-inflammatory activity
    Publication number: 20050080003
    Abstract: The present invention relates to new compounds represented by Formula I: wherein M represents a macrolide subunit of the substructure II: L represents the chain of the substructure III: —X1—(CH2)m-Q-(CH2)n—X2—??III D represents the steroid or nonsteroidal subunit derived from steroid or nonsteroidal (NSAID) drugs with anti-inflammatory activity; The present invention relates also to pharmaceutically acceptable salts and solvates of such prepared compounds, to processe and intermediates for their preparation, as well as to the improved therapeutic action and the use in the treatment of inflammatory diseases and conditions in humans and animals.
    Type: Application
    Filed: April 22, 2004
    Publication date: April 14, 2005
    Inventors: Mladen Mercep, Milan Mesic, Linda Tomaskovic, Stribor Markovic, Boska Hrvacic, Oresta Makaruha, Visnja Poljak
  • Conjugates of immune cell specific macrolide compounds with anti-inflammatory compounds for improved cellular targeting of anti-inflammatory therapy
    Publication number: 20040198677
    Abstract: The present invention relates to novel compounds represented by the structure I and pharmaceutical preparations thereof for the treatment of inflammatory diseases in humans and animals.
    Type: Application
    Filed: December 29, 2003
    Publication date: October 7, 2004
    Inventors: Mlanden Mercep, Milan Mesic, Linda Tomaskovic, Marijana Komac, Boska Hrvacic, Stribor Markovic
  • Thienodibenzoazulene compounds as tumor necrosis factor inhibitors
    Publication number: 20030153750
    Abstract: The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-&agr;) and interleukine 1 (IL-1) in mammals at all diseases and conditions where these mediators are excessively secreted. The compounds of the present invention also demonstrate an analgetic action and can be used to relieve pain.
    Type: Application
    Filed: November 18, 2002
    Publication date: August 14, 2003
    Applicant: Pliva farmaceutska industrija, dionicko drustvo
    Inventors: Mladen Mercep, Milan Mesic, Dijana Pesic, Zeljko Zupanovic, Boska Hrvacic