Patents by Inventor Bounkham Thavonekham

Bounkham Thavonekham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Viral polymerase inhibitors
    Publication number: 20050222236
    Abstract: An enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein A, B, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein, or a salt or ester thereof, as an inhibitor of HCV NS5B polymerase.
    Type: Application
    Filed: February 18, 2005
    Publication date: October 6, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Youla Tsantrizos, Catherine Chabot, Pierre Beaulieu, Christian Brochu, Martin Poirier, Timothy Stammers, Bounkham Thavonekham, Jean Rancourt
  • Non-nucleoside reverse transcriptase inhibitors
    Publication number: 20050054639
    Abstract: Disclosed herein are compounds of formula Ar1—X—W—Ar2 wherein Ar1 and Ar2 represent aryl groups characterized generally as aromatic heterocycles (e.g. imidazolyl or tetrazolyl) or carbocycles (e.g. phenyl or naphthalenyl); the aryl groups are optionally substituted or fused with other heterocycles or carbocycles; the aryl groups can bear substituents such as alkyl, halo or O-alkyl. X is a heteroatom, a valence bond or an optionally substituted divalent methylene, and W represents a spacer; typical spacers include divalent alkylene or alkylene-amido, -amido or -oxy radicals, which may optionally be substituted (e.g. hydroxyl or oxo). A typical compound is a derivative of 2-(N-napthalenyltetrazolylthio)-N-(2-nitrophenyl)acetamide. The compounds have inhibitory activity against Wild Type and single or double mutant strains of HIV.
    Type: Application
    Filed: November 21, 2003
    Publication date: March 10, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Bruno Simoneau, Anne-Marie Faucher, Serge Landry, Jeffrey O'Meara, Bounkham Thavonekham, Christiane Yoakim
  • Non-nucleoside reverse transcriptase inhibitors
    Patent number: 6806265
    Abstract: Compounds represented by formula I: wherein R2 is selected from the group consisting of H, (C1-4)alkyl, halo, haloalkyl, OH, (C1-6)alkoxy, NH(C1-4alkyl) or N(C1-4alkyl)2; R4 is H or Me; R5 is H or Me; R11 is H, (C1-4)alkyl, (C3-4)cycloalkyl and (C1-4)alkyl-(C3-4)cycloalkyl; A is a connecting chain of (C1-3)alkyl; B is O or S; n is 0 or 1; wherein when n is 0: Ring C is 6- or 10-membered aryl or 5- or 6-membered heterocycle having from 1 to 4 heteroatoms selected from the group consisting of O, N, and S, said aryl and said heterocycle being optionally substituted; and E is CONR12R13; CONHNR14R15; NR16COR17; NR18SO2(C1-6)alkyl; SO2NR19R20; or SO2R21; or when n is 1: Ring C is as defined above and E is a single bond or a connecting group; and Ring D is 6- or 10-membered aryl or 5- or 6-membered heterocycle having from 1 to 4 heteroatoms selected from the group consisting of O, N, and S, said aryl and said heterocycle being optionally substituted with from 1 to 5 substituents; or a salt or
    Type: Grant
    Filed: May 6, 2003
    Date of Patent: October 19, 2004
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Bruno Simoneau, Serge Landry, Eric Malenfant, Julie Naud, Jeffrey O'Meara, Bounkham Thavonekham, Christiane Yoakim
  • Non-nucleoside reverse transcriptase inhibitors
    Publication number: 20040106791
    Abstract: Compounds represented by formula I: 1
    Type: Application
    Filed: September 15, 2003
    Publication date: June 3, 2004
    Applicant: Boehringer Ingelheim (Canada) Ltd.
    Inventors: Christiane Yoakim, Eric Malenfant, Bounkham Thavonekham, William Ogilvie, Robert Deziel
  • Non-nucleoside reverse transcriptase inhibitors
    Publication number: 20040006071
    Abstract: Compounds represented by formula I: 1
    Type: Application
    Filed: May 6, 2003
    Publication date: January 8, 2004
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Bruno Simoneau, Serge Landry, Eric Malenfant, Julie Naud, Jeffrey O'Meara, Bounkham Thavonekham, Christiane Yoakim
  • Anti-herpesvirus compounds and methods for identifying, making and using same
    Patent number: 6458959
    Abstract: This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives.
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: October 1, 2002
    Assignees: Boehringer Ingelheim Pharmaceuticals, Inc., Boehringer Ingelheim (Canada) Ltd.
    Inventors: James J. Crute, Anne-Marie Faucher, Christine A. Grygon, Karl D. Hargrave, Bruno Simoneau, Bounkham Thavonekham
  • Anti-herpesvirus compounds and methods for identifying, making and using same
    Patent number: 6348477
    Abstract: This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: February 19, 2002
    Assignees: Boehringer Ingelheim(Canada) Ltd., Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: James J. Crute, Anne-Marie Faucher, Christine A. Grygon, Karl D. Hargrave, Bruno Simoneau, Bounkham Thavonekham
  • Antiherpes virus compounds and methods for their preparation and use
    Patent number: 6288091
    Abstract: This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: September 11, 2001
    Assignees: Boehringer Ingelheim Ltd., Boehringer Ingelheim Pharm. Inc.
    Inventors: J. James Crute, Anne-Marie Faucher, Christine Grygon, Karl D. Hargrave, Bruno Simoneau, Bounkham Thavonekham
  • Anti-herpesvirus compounds and methods for identifying, making and using same
    Patent number: 6057451
    Abstract: This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also relates to thiazolyphenyl derivatives that inhibit the herpes helicase-primase and to pharmaceutical compositions comprising the thiazolylphenyl derivatives, to methods of using and methods of producing the thiazolylphenyl derivatives.
    Type: Grant
    Filed: December 4, 1996
    Date of Patent: May 2, 2000
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: James J. Crute, Anne-Marie Faucher, Christine A. Grygon, Karl D. Hargrave, Bruno Simoneau, Bounkham Thavonekham
  • Practical synthesis of urea derivatives
    Patent number: 5925762
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: July 20, 1999
    Assignee: Boehringer Ingelheim (Canada) Ltd.
    Inventor: Bounkham Thavonekham