Abstract: The current disclosure relates to methods, compositions and kits for detecting modified adenosine in a target RNA molecule. Aspects relate to a method for detecting modified adenosine in a target ribonucleic acid (RNA) comprising contacting the target RNA with an adenosine deaminase enzyme (adenosine deaminase, RNA-specific) to generate a target RNA with deaminated adenosines and sequencing the target RNA with deaminated adenosines; wherein the modified adenosine is detected when the nucleotide sequence includes adenosine within a m6A motif.

Abstract: The present application discloses a search method and apparatus, which include specifically: after a search keyword is acquired, acquiring a search result of the search keyword with use of a fine ranking layer of a vertical search architecture if the search keyword is a keyword related to vertical search; processing a display effect of the search result with use of a business layer of the vertical search architecture to obtain a target search result; and transmitting the target search result to a display device. That is, in embodiments of the present application, a search result of a search keyword may be acquired with use of a fine ranking layer of a vertical search architecture, and 10 orders of magnitude of data can generally be searched at the fine ranking layer compared with a business layer, therefore, a more complete and accurate search result can be obtained.

Abstract: The current disclosure relates to methods, compositions and kits for detecting modified adenosine in a target RNA molecule. Aspects relate to a method for detecting modified adenosine in a target ribonucleic acid (RNA) comprising contacting the target RNA with an adenosine deaminase enzyme (adenosine deaminase, RNA-specific) to generate a target RNA with deaminated adenosines and sequencing the target RNA with deaminated adenosines; wherein the modified adenosine is detected when the nucleotide sequence includes adenosine within a m6A motif.

Abstract: The present application discloses a search method and apparatus, which include specifically: after a search keyword is acquired, acquiring a search result of the search keyword with use of a fine ranking layer of a vertical search architecture if the search keyword is a keyword related to vertical search; processing a display effect of the search result with use of a business layer of the vertical search architecture to obtain a target search result; and transmitting the target search result to a display device. That is, in embodiments of the present application, a search result of a search keyword may be acquired with use of a fine ranking layer of a vertical search architecture, and 10 orders of magnitude of data can generally be searched at the fine ranking layer compared with a business layer, therefore, a more complete and accurate search result can be obtained.