Abstract: A cleaning method for a cleaning device includes: acquiring a grid map of a region to be cleaned; dividing a passable region in the grid map into a plurality of candidate regions; screening the plurality of candidate regions; prioritizing a plurality of screened candidate regions, and corresponding the plurality of screened candidate regions with different priorities to different cleaning parameters; and cleaning the plurality of screened candidate regions according to priority sorting, the cleaning parameters include at least one of a cleaning frequency, cleaning time, cleaning agent addition information and a cleaning mode. Adopting the cleaning method for the cleaning device effectively solves problems in that cleaning efficiency of a robot vacuum cleaner is relatively low in related technologies.

Abstract: Color filter array patterns are provided for enhancing an image sensor's light sensitivity while preserving a color accuracy for image signal processing applications. In one example, an image sensor can include a substrate layer containing a first set of photodiodes and a second set of photodiodes, wherein each of the first set of photodiodes is larger than each of the second set of photodiodes; a first color filter array (CFA) covering the first set of photodiodes, wherein the first CFA includes a first set of color filters and a portion of the first set of color filters includes one or more clear filters; a second CFA covering the second set of photodiodes, wherein the second CFA includes a second set of color filters that is different than the first set of color filters; and one or more lenses covering the first CFA and the second CFA.

Abstract: The present invention relates to the technical field of medicinal chemistry, and particularly to a method for preparing a 3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and use thereof. Specifically, a compound of Formula I, or a pharmaceutically acceptable salt, or an optical isomer, or an isotope-substituted form thereof is provided. The compound effectively inhibits the SARS-CoV-2 3CLpro activity, and is useful in the preparation of a SARS-CoV-2 3CLpro inhibitor to block the replication and transcription of SARS-CoV-2 viruses in patients. The compound prepared in the present invention has high in-vitro safety, and very good prospect of application in the preparation of SARS-CoV-2 3CLpro inhibitors and anti-SARS-CoV-2 drugs.

Abstract: The present disclosure provides methods, compositions, and devices for making and using three-dimensional biological tissues that accurately mimic native physiology, architecture, and other properties of native tissues for use in, among other applications, drug testing, tissue repair and/or treatment, and regenerative medicine.

Abstract: A method of interacting with an artificial-reality (AR) content at an AR headset that includes cameras and displays is described. The method includes, while the AR headset has a first position within a physical environment that includes an object, if a distance of the object is within a threshold collision distance from the AR headset, presenting a meshed representation of the object. The meshed representation is displayed at first respective locations on the displays such that the meshed representation is viewable within the artificial reality. After the AR headset moves to a second position with a different distance, and if the different distance is within the threshold collision distance from the AR headset, moving the meshed representation of the object to second respective locations within the artificial reality. The second respective locations correspond to the position of the object in the physical environment.

Abstract: The present disclosure provides methods, compositions, and devices for making and using three-dimensional biological tissues that accurately mimic native physiology, architecture, and other properties of native tissues for use in, among other applications, drug testing, tissue repair and/or treatment, and regenerative medicine.

Abstract: A method of interacting with an artificial-reality (AR) content at an AR headset that includes cameras and displays is described. The method includes, while the AR headset has a first position within a physical environment that includes an object, if a distance of the object is within a threshold collision distance from the AR headset, presenting a meshed representation of the object. The meshed representation is displayed at first respective locations on the displays such that the meshed representation is viewable within the artificial reality. After the AR headset moves to a second position with a different distance, and if the different distance is within the threshold collision distance from the AR headset, moving the meshed representation of the object to second respective locations within the artificial reality. The second respective locations correspond to the position of the object in the physical environment.

Abstract: Methods and systems are provided for preserving dynamic range in images. In some aspects, a process can include steps for receiving, at an autonomous vehicle system, image data from an image sensor, generating, by the autonomous vehicle system, a high dynamic range (HDR) output by performing HDR processing on the image data from the image sensor, generating, by the autonomous vehicle system, a least significant bit (LSB) output by performing LSB processing on the image data from the image sensor, and generating, by the autonomous vehicle system, an 8-bit output by performing a buffer process on the HDR output and the LSB output of the image sensor.

Abstract: Color filter array patterns are provided for enhancing an image sensor’s light sensitivity while preserving a color accuracy for image signal processing applications. In one example, an image sensor can include a substrate layer containing a first set of photodiodes and a second set of photodiodes, wherein each of the first set of photodiodes is larger than each of the second set of photodiodes; a first color filter array (CFA) covering the first set of photodiodes, wherein the first CFA includes a first set of color filters and a portion of the first set of color filters includes one or more clear filters; a second CFA covering the second set of photodiodes, wherein the second CFA includes a second set of color filters that is different than the first set of color filters; and one or more lenses covering the first CFA and the second CFA.

Abstract: A platform system receives sensor data describing the state and orientation of a tracked object and models the pose of the tracked object to determine user interactions with the platform system. To ensure that incorrect sensor data due to a saturation event or connection loss does not impact user experience, the platform system identifies regions for correction in sensor data streams based on the sensor data being at or above a saturation limit or not being received. The platform system predicts sensor data for an identified region of correction by applying a fit corresponding to points adjacent to the region for correction and determining predicted sensor data using the applied fit. The predicted sensor data is used to correct the modeled pose for the tracked object.

Abstract: Methods and systems are provided for preserving dynamic range in images. In some aspects, a process can include steps for receiving, at an autonomous vehicle system, image data from an image sensor, generating, by the autonomous vehicle system, a high dynamic range (HDR) output by performing HDR processing on the image data from the image sensor, generating, by the autonomous vehicle system, a least significant bit (LSB) output by performing LSB processing on the image data from the image sensor, and generating, by the autonomous vehicle system, an 8-bit output by performing a buffer process on the HDR output and the LSB output of the image sensor.

Abstract: Described herein is a cell culture system for constructing a perfusable network of self-assembled cells comprising a multi-well plate embedded with microchannels connecting a central well with at least one inlet well and at least one outlet well, the central well for culturing seeded cells within an extracellular matrix, wherein the perfusable network allows perfusion through the microchannels connecting the central well with at least one inlet well and at least one outlet well. The cell culture system allows the array of perfusable networks formed, connected, and perfused inside the multi-well plate to be accessible and/or extractable from the top of the central well. In aspect, the cell culture system can improve the experimental throughputs of organ-on-a-chip systems and expand the application of microphysiological systems to regenerative cell therapy. A perfusable network of self-assembled cells and method of making thereof using the cell culture system described herein are also provided.

Abstract: Color filter array patterns are provided for enhancing an image sensor's light sensitivity while preserving a color accuracy for image signal processing applications. In one example, an image sensor can include a substrate layer containing a first set of photodiodes and a second set of photodiodes, wherein each of the first set of photodiodes is larger than each of the second set of photodiodes; a first color filter array (CFA) covering the first set of photodiodes, wherein the first CFA includes a first set of color filters and a portion of the first set of color filters includes one or more clear filters; a second CFA covering the second set of photodiodes, wherein the second CFA includes a second set of color filters that is different than the first set of color filters; and one or more lenses covering the first CFA and the second CFA.

Abstract: A platform system receives sensor data describing the state and orientation of a tracked object and models the pose of the tracked object to determine user interactions with the platform system. To ensure that incorrect sensor data due to a saturation event or connection loss does not impact user experience, the platform system identifies regions for correction in sensor data streams based on the sensor data being at or above a saturation limit or not being received. The platform system predicts sensor data for an identified region of correction by applying a fit corresponding to points adjacent to the region for correction and determining predicted sensor data using the applied fit. The predicted sensor data is used to correct the modeled pose for the tracked object.

Abstract: Described herein are various technologies pertaining to a sensor system for an autonomous vehicle (AV) that includes a single photon accelerated diode (SPAD) array. The SPAD array includes several pixels. A filter layer is arranged proximate the several pixels, where the filter layer includes color filter portions and unfiltered portions that are respectively aligned with first pixels of the SPAD array and second pixels of the SPAD array. A computing system determines both range to an object and information pertaining to color of the object based upon values read out from the pixels of the SPAD array.

Abstract: Embodiments described herein relate generally to devices, apparatuses, and systems with embedded electrodes for rowing, maintaining, and/or using 3D tissues in vitro. The devices, apparatuses, and systems described herein can provide scalable, automated tissue stimulation.

Abstract: Methods and systems are provided for preserving dynamic range in images. In some aspects, a process can include steps for receiving, at an autonomous vehicle system, image data from an image sensor, generating, by the autonomous vehicle system, a high dynamic range (HDR) output by performing HDR processing on the image data from the image sensor, generating, by the autonomous vehicle system, a least significant bit (LSB) output by performing LSB processing on the image data from the image sensor, and generating, by the autonomous vehicle system, an 8-bit output by performing a buffer process on the HDR output and the LSB output of the image sensor.

Abstract: In one embodiment, a method includes receiving, from a controller, a data packet including (1) a plurality of samples each corresponding to measurements from a motion sensor and (2) a timestamp corresponding to a measurement time of one of the samples as measured by a clock of the controller; determining, based on the timestamp, an estimated measurement time relative to a local clock for each of the plurality of samples that is not associated with the timestamp; and converting each of the timestamp and the estimated measurement times to a corresponding synchronization time using a learned relationship relating the clock of the controller and the local clock. The learned relationship is iteratively learned based on previously received data packets from the controller. The synchronization time associated with each of the plurality of samples represents an estimated time, relative to the local clock, at which the sample was measured.

Abstract: An image sensor pixel comprises a subpixel and a polarization pixel. The subpixel includes a group of photodiodes disposed in semiconductor material, a shared microlens optically aligned over the group of photodiodes, and a subpixel color filter disposed between the group of photodiodes and the shared microlens. The polarization pixel includes a first photodiode disposed in the semiconductor material, an unshared microlens optically aligned over the first photodiode, and a polarization filter disposed between the first photodiode and the unshared microlens. The shared microlens has a first lateral area. The unshared microlens has a second lateral area less than the first lateral area of the shared microlens.

Abstract: An image sensor includes a plurality of photodiodes, a plurality of color filters, and a plurality of microlenses. The plurality of photodiodes are arranged as a photodiode array, each of the plurality of photodiodes disposed within respective portions of a semiconductor material with a first lateral area. The plurality of color filters are arranged as a color filter array optically aligned with the photodiode array. Each of the plurality of color filters having a second lateral area greater than the first lateral area. The plurality of microlenses are arranged as a microlens array optically aligned with the color filter array and the photodiode array. Each of the plurality of microlenses have a third later area greater than the first lateral area and less than the second lateral area.