Abstract: The present invention relates to application of gossypol and its optical isomers to preparation of an anti-Coronavirus drug. Specifically disclosed is application of pharmaceutically acceptable salts, solvates, isotopes, stereoisomers, stereoisomer mixtures, and tautomers of the gossypol and its optical isomers to preparation of a drug for preventing and/or treating a disease caused by a Coronavirus. The Coronavirus is MERS-CoV, SARS-CoV, or SARS-CoV-2. It is found in the present invention for the first time that the gossypol and its optical isomers can inhibit the activity of Coronavirus 3CL proteases to achieve an anti-Coronavirus effect. The half maximal inhibitory concentrations of gossypol and (?)-gossypol to SARS-CoV proteases and SARS-CoV-2 3CL proteases are all lower than 10 ?M. The anti-Coronavirus 3CL protease effect is good. Therefore, the gossypol and its optical isomers have the potential for use in the preparation of a drug for preventing and/or treating novel Coronavirus infections.

Abstract: A laser patterning method may include fabricating one or more precursor sites on a sample, generating an illumination beam including one or more pulse bursts, each pulse burst including two or more laser pulses, and scanning the illumination beam across the sample along a scan pattern including locations of the one or more precursor sites. At least one of intensities, temporal inter-pulse spacings, or spatial overlap between the two or more laser pulses in the illumination beam may be selected to selectively excite the one or more precursor sites to selectively modify the sample at the one or more precursor sites to form one or more patterned features, where a dimension of at least one feature in the one or more patterned features along at least one dimension is smaller than a size of the illumination beam on the sample.

Abstract: Disclosed is a resilient route generation system for reliable communication of a phasor measurement system of a power grid. A named data network is a new network architecture to improve the communication reliability between a phasor measurement unit and a phasor measurement concentrator in power transmission and distribution networks. The lost data packets in a current router can be directly recovered from an upstream router with resilient route, and the optimal RR selection will maximize the success rate of retransmission of lost data packets, thus maximizing the network reliability. The mesh network and ring network structure of the power grid are fully utilized, and a resilient route generation system is provided, wherein the resilient route of each communication pair includes a corresponding primary path and a plurality of redundant sub paths, so that the success rate of retransmission of lost data packets and the network reliability are maximized.

Abstract: Disclosed is a reliable resilient router for a wide-area phasor measurement system of a power grid. The reliable resilient router includes a Data-type data packet processing module, a RetransReq data packet processing module, a RetransReport data packet processing module, a basic data packet processing module, a multi-path forwarding state table module, a content storage queue module and a physical port. The reliable resilient router of the present invention realizes active detection of a lost data packet and a single or batch retransmission mechanism, so that the lost data packet can be directly recovered in the grid from an upstream router through which the lost data packet passes, which improves the recovery time success rate and the high efficiency of the lost data packet, and guarantees the safe and stable operation of the wide-area phasor measurement system of the power grid.

Abstract: Disclosed is a reliable resilient router for a wide-area phasor measurement system of a power grid. The reliable resilient router includes a Data-type data packet processing module, a RetransReq data packet processing module, a RetransReport data packet processing module, a basic data packet processing module, a multi-path forwarding state table module, a content storage queue module and a physical port. The reliable resilient router of the present invention realizes active detection of a lost data packet and a single or batch retransmission mechanism, so that the lost data packet can be directly recovered in the grid from an upstream router through which the lost data packet passes, which improves the recovery time success rate and the high efficiency of the lost data packet, and guarantees the safe and stable operation of the wide-area phasor measurement system of the power grid.

Abstract: An ice sledding device includes a blade mounted on a main body support. The main body support of the ice sledding device is formed with an inclined top surface for supporting the player during the normal user of the ice sledding device.