Patents by Inventor Boyd M. Goodson

Boyd M. Goodson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cleavable agents
    Patent number: 11834416
    Abstract: The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: December 5, 2023
    Assignees: Board of Trustees of Southern Illinois University, Vanderbilt University
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Bryce E. Kidd, Jamil A. Mashni, Miranda Limbach, Yuqing Hou, Fan Shi
  • CLEAVABLE AGENTS
    Publication number: 20230150943
    Abstract: The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.
    Type: Application
    Filed: January 4, 2023
    Publication date: May 18, 2023
    Applicants: Board of Trustees of Southern Illinois University, Vanderbilt University
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Bryce E. Kidd, Jamil A. Mashni, Miranda Limbach, Yuqing Hou, Fan Shi
  • Removal of homogeneous catalysts from NMR/MRI agents hyperpolarized via sabre or PHIP
    Patent number: 11571686
    Abstract: The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.
    Type: Grant
    Filed: February 17, 2020
    Date of Patent: February 7, 2023
    Assignees: Board of Trustees of Southern Illinois University, Vanderbilt University, The Regents of the University of California
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Igor V. Koptyug, Kirill V. Kovtunov, Roman V. Shchepin, Bryce E. Kidd, Jonathan Gesiorski, Max E. Gemeinhardt, Danila A. Barskiy
  • REMOVAL OF HOMOGENEOUS CATALYSTS FROM NMR/MRI AGENTS HYPERPOLARIZED VIA SABRE OR PHIP
    Publication number: 20230001400
    Abstract: The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.
    Type: Application
    Filed: February 17, 2020
    Publication date: January 5, 2023
    Applicants: Board of Trustees of Southern Illinois University, Vanderbilt University, The Regents of the University of California
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Igor V. Koptyug, Kirill V. Kovtunov, Roman V. Shchepin, Bryce E. Kidd, Jonathan Gesiorski, Max E. Gemeinhardt, Danila A. Barskiy
  • REMOVAL OF HOMOGENEOUS CATALYSTS FROM NMR/MRI AGENTS HYPERPOLARIZED VIA SABRE OR PHIP
    Publication number: 20210252493
    Abstract: The present disclosure provides a method that embodies a simple and effective route to remove homogeneous catalysts from solutions wherein NMR/MRI signal amplification by reversible exchange (SABRE) or parahydrogen-induced polarization (PHIP) is performed. A method for recovering a homogeneous SABRE/PHIP catalyst for reuse is also described.
    Type: Application
    Filed: February 17, 2020
    Publication date: August 19, 2021
    Applicants: Board of Trustees of Southern Illinois University, Vanderbilt University, The Regents of the University of California
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Igor V. Koptyug, Kirill V. Kovtunov, Roman V. Shchepin, Bryce E. Kidd, Jonathan Gesiorski, Max E. Gemeinhardt, Danila A. Barskiy
  • CLEAVABLE AGENTS
    Publication number: 20200172493
    Abstract: The present disclosure is directed to a cleavable agent for enhanced magnetic resonance generally corresponding to the formula Y-L-R, wherein Y represents a catalyst-binding moiety having at least one isotopically labeled heteroatom, L represents a cleavable bond, and R represents a hyperpolarized payload having at least one isotopically labeled carbon. Also disclosed herein is a method of cleaving the cleavable agent for enhanced magnetic resonance.
    Type: Application
    Filed: November 27, 2019
    Publication date: June 4, 2020
    Applicants: Board of Trustees of Southern Illinois University, Vanderbilt University
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Bryce E. Kidd, Jamil A. Mashni, Miranda Limbach, Yuqing Hou, Fan Shi
  • Water soluble catalysts for NMR/MRI enhancement
    Patent number: 9790245
    Abstract: Iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. The iridium catalysts can be water-soluble iridium catalysts. Also provided are methods for preparing iridium catalysts, and methods of activating and using iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: October 17, 2017
    Assignees: Vanderbilt University, Board of Trustees of Southern Illinois University
    Inventors: Eduard Y. Chekmenev, Boyd M. Goodson, Roman V. Shchepin, Milton L. Truong, Ping He, Quinn A. Best, Fan Shi, Kirsten A. Groome, Aaron M. Coffey
  • Heterogeneous catalysts for NMR/MRI enhancement via signal amplification by reversible exchange (SABRE)
    Patent number: 9707550
    Abstract: Heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. Also provided are methods for preparing heterogeneous iridium catalysts, and methods of using heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: July 18, 2017
    Assignees: Vanderbilt University, Board of Trustees of Southern Illinois Univeristy
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Fan Shi, Aaron M. Coffey
  • WATER SOLUBLE CATALYSTS FOR NMR/MRI ENHANCEMENT
    Publication number: 20160045907
    Abstract: Iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. The iridium catalysts can be water-soluble iridium catalysts. Also provided are methods for preparing iridium catalysts, and methods of activating and using iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.
    Type: Application
    Filed: July 16, 2015
    Publication date: February 18, 2016
    Inventors: Eduard Y. Chekmenev, Boyd M. Goodson, Roman V. Shchepin, Milton L. Truong, Ping He, Quinn A. Best, Fan Shi, Kirsten A. Groome, Aaron M. Coffey
  • HETEROGENEOUS CATALYSTS FOR NMR/MRI ENHANCEMENT VIA SIGNAL AMPLIFICATION BY REVERSIBLE EXCHANGE (SABRE)
    Publication number: 20160016159
    Abstract: Heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange are provided. Also provided are methods for preparing heterogeneous iridium catalysts, and methods of using heterogeneous iridium catalysts for nuclear spin polarization enhancement in solution via signal amplification by reversible exchange.
    Type: Application
    Filed: July 16, 2015
    Publication date: January 21, 2016
    Inventors: Boyd M. Goodson, Eduard Y. Chekmenev, Fan Shi, Aaron M. Coffey