Patents by Inventor Bozhi Tian
Bozhi Tian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240101997Abstract: The present disclosure provides a device and method for a scalable production of extracellular vesicles (EVs) by electrical stimulation. Also provided herein is a composition comprising the EVs loaded with or without therapeutic agents and the method of using this composition for treating diseases.Type: ApplicationFiled: September 13, 2023Publication date: March 28, 2024Inventors: Bozhi Tian, Lingyuan Meng, Pengju Li, Wen Li
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Publication number: 20240100354Abstract: This disclosure relates to methods for modulating activity of cells and tissue with materials that are capable of being activated by light, such methods useful for treating diseases. The disclosure also provides devices and systems suitable for use in such methods, particularly devices and systems having oxygen plasma-treated p-type (boron) silicon.Type: ApplicationFiled: October 16, 2020Publication date: March 28, 2024Inventors: Bozhi Tian, Menahem Rotenberg, Aleksander Prominski
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Publication number: 20240009630Abstract: This disclosure relates to methods for modulating activity of cells and tissue with materials that are capable of being activated by an energy pulse, such methods useful for treating diseases. The disclosure also provides devices and systems suitable for use in such methods, particularly devices and systems having a carbon-based material comprising one or more monolithic porous carbon membranes.Type: ApplicationFiled: November 30, 2021Publication date: January 11, 2024Inventors: Bozhi Tian, Aleksander Prominski, Lingyuan Meng
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Publication number: 20230183075Abstract: Compositions and methods directed to the synthesis and use of silicon carbide with, biomedical applications is provided. The method of synthesis includes providing a polydimethysiloxane (PDM'S) substrate, and irradiating at least a portion of the substrate with a laser under conditions sufficient to produce silicon carbide comprising 3C silicon carbide (3C-SiE). The composition can be used to modulate biological activity through electrical, chemical and heat stimuli.Type: ApplicationFiled: April 13, 2021Publication date: June 15, 2023Inventors: Bozhi Tian, Vishnu Nair, Aleksander Prominski
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Publication number: 20230048814Abstract: A composition and method directed to the formation of a biodegradable composition with enhanced mechanical properties is provided. The composition includes starch in an amount from 15-45 %, chitosan in an amount ranging from 1-50 wt%, poly acrylamide in an amount ranging from 1-10 wt %, and water in an amount ranging from 25-85 wt %. The composition can be provided for food packaging or otherwise as a protective material.Type: ApplicationFiled: December 18, 2020Publication date: February 16, 2023Inventors: Bozhi Tian, Herbert Wang, Yin Fang, Yiliang Lin
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Patent number: 10988735Abstract: Described herein are tissues containing semiconductor nanomaterials. In some embodiments, the tissues include vascular cells, cardiomyocytes, and/or cardiac fibroblasts. The tissue may be scaffold-free. In some embodiments, the tissue includes an electrically conductive network. The tissue may exhibit synchronized electrical signal propagation within the tissue. In some embodiments, the tissue exhibits increased functional assembly of cardiac cells and/or increased cardiac specific functions compared to a cardiac tissue prepared using a conventional tissue culture method. Methods of preparing and using such tissues are also described herein.Type: GrantFiled: January 15, 2016Date of Patent: April 27, 2021Assignees: Clemson University Research Foundation, MUSC Foundation for Research Development, The University of ChicagoInventors: Ying Mei, Tan Yu, Dylan Richards, Donald R. Menick, Bozhi Tian
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Publication number: 20200390803Abstract: This disclosure relates to methods for modulating activity of a cell capable of being activated by light and treating diseases with such methods. The disclosure also provides systems suitable for use in such methods, particularly systems having silicon nanostructures.Type: ApplicationFiled: February 19, 2019Publication date: December 17, 2020Inventors: Bozhi Tian, Francisco Bezanilla, Erin Adams, Ramya Parameswaran, Yuanwen Jiang, João L. Carvalho-de-Souza, Kelliann C. Koehler, Michael G. Burke
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Patent number: 10663450Abstract: Provided herein are Si-based materials, methods of making the Si-based materials, and methods for using the Si-based materials. In embodiments, a silicon-based material comprises an aggregate of particles, the particles comprising an ordered array of nanostructures, the nanostructures comprising amorphous silicon, wherein at least some pairs of adjacent nanostructures are connected by one or more bridges comprising amorphous silicon, the one or more bridges extending from the surface of one nanostructure of the pair to the surface of the other nanostructure in the pair.Type: GrantFiled: June 14, 2017Date of Patent: May 26, 2020Assignee: The University of ChicagoInventors: Bozhi Tian, Francisco Bezanilla, Yuanwen Jiang, João L. Carvalho-de-Souza
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Patent number: 10369255Abstract: The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like.Type: GrantFiled: July 21, 2016Date of Patent: August 6, 2019Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, Children's Medical Center CorporationInventors: Charles M. Lieber, Jia Liu, Bozhi Tian, Tal Dvir, Robert S. Langer, Daniel S. Kohane
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Patent number: 10355229Abstract: The present invention generally relates to nanoscale wires and tissue engineering. Systems and methods are provided in various embodiments for preparing cell scaffolds that can be used for growing cells or tissues, where the cell scaffolds comprise nanoscale wires. In some cases, the nanoscale wires can be connected to electronic circuits extending externally of the cell scaffold. Such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like. This approach thus allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits.Type: GrantFiled: July 8, 2016Date of Patent: July 16, 2019Assignee: President and Fellows of Harvard CollegeInventors: Charles M. Lieber, Bozhi Tian, Jia Liu
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Publication number: 20170369847Abstract: Provided herein are tissues containing semiconductor nanomaterials and methods of preparing and using the same.Type: ApplicationFiled: January 15, 2016Publication date: December 28, 2017Inventors: Ying Mei, Tan Yu, Dylan Richards, Donald R. Menick, Bozhi Tian
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Publication number: 20170363607Abstract: Provided herein are Si-based materials, methods of making the Si-based materials, and methods for using the Si-based materials. In embodiments, a silicon-based material comprises an aggregate of particles, the particles comprising an ordered array of nanostructures, the nanostructures comprising amorphous silicon, wherein at least some pairs of adjacent nanostructures are connected by one or more bridges comprising amorphous silicon, the one or more bridges extending from the surface of one nanostructure of the pair to the surface of the other nanostructure in the pair.Type: ApplicationFiled: June 14, 2017Publication date: December 21, 2017Inventors: Bozhi Tian, Francisco Bezanilla, Yuanwen Jiang, João L. Carvalho-de-Souza
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Patent number: 9786850Abstract: The present invention generally relates to nanoscale wires and tissue engineering. Systems and methods are provided in various embodiments for preparing cell scaffolds that can be used for growing cells or tissues, where the cell scaffolds comprise nanoscale wires. In some cases, the nanoscale wires can be connected to electronic circuits extending externally of the cell scaffold. Such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like. This approach thus allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits.Type: GrantFiled: September 4, 2013Date of Patent: October 10, 2017Assignee: President and Fellows of Harvard CollegeInventors: Charles M. Lieber, Bozhi Tian, Jia Liu
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Patent number: 9638717Abstract: The present invention generally relates to nanoscale wires for use in sensors and other applications. In various embodiments, a probe comprising a nanotube (or other nanoscale wire) is provided that can be directly inserted into a cell to determine a property of the cell, e.g., an electrical property. In some cases, only the tip of the nanoscale wire is inserted into the cell; this tip may be very small relative to the cell, allowing for very precise study. In some aspects, the tip of the probe is held by a holding member positioned on a substrate, e.g., at an angle, which makes it easier for the probe to be inserted into the cell. The nanoscale wire may also be connected to electrodes and/or form part of a transistor, such that a property of the nanoscale wire, and thus of the cell, may be determined. Such probes may also be useful for studying other samples besides cells.Type: GrantFiled: May 2, 2013Date of Patent: May 2, 2017Assignee: President and Fellows of Harvard CollegeInventors: Charles M. Lieber, Ruixuan Gao, Steffen Strehle, Xiaojie Duan, Bozhi Tian, Itzhaq Cohen-Karni, Ping Xie, Quan Qing
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Publication number: 20170072109Abstract: The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like.Type: ApplicationFiled: July 21, 2016Publication date: March 16, 2017Inventors: Charles M. Lieber, Jia Liu, Bozhi Tian, Tal Dvir, Robert S. Langer, Daniel S. Kohane
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Publication number: 20170069858Abstract: The present invention generally relates to nanoscale wires and tissue engineering. Systems and methods are provided in various embodiments for preparing cell scaffolds that can be used for growing cells or tissues, where the cell scaffolds comprise nanoscale wires. In some cases, the nanoscale wires can be connected to electronic circuits extending externally of the cell scaffold. Such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like. This approach thus allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits.Type: ApplicationFiled: July 8, 2016Publication date: March 9, 2017Inventors: Charles M. Lieber, Bozhi Tian, Jia Liu
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Patent number: 9457128Abstract: The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like.Type: GrantFiled: September 4, 2013Date of Patent: October 4, 2016Assignee: President and Fellows of Harvard CollegeInventors: Charles M. Lieber, Jia Liu, Bozhi Tian, Tal Dvir, Robert S. Langer, Daniel S. Kohane
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Publication number: 20160282303Abstract: The present invention generally relates to nanoscale devices and methods, including bent nanowires and other bent nanoscale objects, and in particular, the ability to probe cells with nanoscale objects. In some aspects, nanoscale objects, including nanowires, are provided that facilitate cell probing, e.g. nanowires that are surface modified such that cells can fuse with the nanowires. Devices including nanoscale objects are provided that allow small or large scale (e.g., multiplexed) probing of cells, and related methods of making such nanoscale objects and devices, and methods of investigating cells, are provided by certain embodiments of the invention. In a related set of embodiments, the present invention is generally related to bent nanowires and other bent nanoscale objects. For instance, in one aspect, the present invention is generally related to a semiconductor nanoscale wire having at least one kink. The semiconductor nanoscale wire may be formed out of any suitable semiconductor, e.g.Type: ApplicationFiled: February 18, 2016Publication date: September 29, 2016Inventors: Charles M. Lieber, Bozhi Tian, Ping Xie, Thomas J. Kempa, Itzhaq Cohen-Karni, Quan Qing, Xiaojie Duan
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Publication number: 20160193385Abstract: The present invention generally relates to porous membranes and other porous articles. In one aspect, the present invention is generally directed to porous membranes and other articles that have a pore size comparable to feature sizes of the extracellular matrix. Such articles may be useful, for example, for tissue engineering (e.g., as a substrate for culturing cells), as a filter, or for other applications. In some cases, the membranes may be formed from biocompatible and/or biodegradable materials. In some embodiments, such membranes may be formed using solvent evaporation induced self-assembly (EISA) techniques, although other techniques may be used in other embodiments. Still other aspects of the present invention are directed to methods of using such articles, kits involving such articles, and the like.Type: ApplicationFiled: August 14, 2014Publication date: July 7, 2016Applicant: Children's Medical Center CorporationInventors: Bozhi Tian, Daniel S. Kohane
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Patent number: 9297796Abstract: Kinked nanowires are used for measuring electrical potentials inside simple cells. An improved intracellular entrance is achieved by modifying the kinked nanowires with phospholipids.Type: GrantFiled: September 24, 2010Date of Patent: March 29, 2016Assignee: President and Fellows of Harvard CollegeInventors: Bozhi Tian, Ping Xie, Thomas J. Kempa, Charles M. Lieber, Itzhaq Cohen-Karni, Quan Qing, Xiaojie Duan