Patents by Inventor Brad Amendt

Brad Amendt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods to generate epithelial cells
    Patent number: 10920195
    Abstract: The invention provides in certain embodiments, a method of generating a re-programmed differentiated epithelial cell comprising (a) contacting a non-stem somatic cell obtained from a subject with an effective amount of a de-differentiation agent to form a de-differentiated cell, and (b) transfecting the de-differentiated cell with an expression cassette comprising a promoter operably linked to a nucleic acid encoding a conversion agent to form a re-programmed differentiated cell. The invention also provides in certain embodiments, a method of generating a re-programmed differentiated epithelial cell comprising (a) contacting a non-stem somatic cell obtained from a subject with an effective amount of a de-differentiation agent to form a de-differentiated cell, and (b) contacting the de-differentiated cell with a conversion agent to form a re-programmed differentiated cell.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: February 16, 2021
    Assignee: University of Iowa Research Foundation
    Inventors: Brad A. Amendt, Thad Sharp
  • MicroRNA-200 based approaches for modulating bone formation inhibition and bone regeneration
    Patent number: 10717980
    Abstract: In certain embodiments, the present invention provides the use of microRNA (miR)-200a to inhibit ossification and bone formation.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: July 21, 2020
    Assignee: University of Iowa Research Foundation
    Inventors: Liu Hong, Brad Amendt, Thad Sharp, Aliasger Salem
  • Methods to prevent or treat periodontitis or peri-implantitis
    Patent number: 10669543
    Abstract: Compositions and methods to prevent, inhibit or treat aveolar or periodontal bone loss, enhance bone regeneration, prevent, inhibit or treat peri-implantitis or periodontitis, e.g., periodontitis or peri-implantitis associated with bone loss, or to prevent, inhibit or treat osteoarthritis are provided.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: June 2, 2020
    Assignee: University of Iowa Research Foundation
    Inventors: Liu Hong, Brad A. Amendt, Aliasger K. Salem, Satheesh Elangovan, Gustavo Avila Ortiz, Thad Sharp
  • Microrna inhibitor system and methods of use thereof
    Patent number: 10519443
    Abstract: The present invention relates to plasmid-based miR inhibitory systems (PMIS), miR inhibitors and methods of use of these systems and inhibitors.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: December 31, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Brad A. Amendt, Huojun Cao
  • MICRORNA-200 BASED APPROACHES FOR MODULATING BONE FORMATION INHIBITION AND BONE REGENERATION
    Publication number: 20190264206
    Abstract: In certain embodiments, the present invention provides the use of microRNA (miR)-200a to inhibit ossification and bone formation.
    Type: Application
    Filed: March 12, 2019
    Publication date: August 29, 2019
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Liu Hong, Brad Amendt, Thad Sharp, Aliasger Salem
  • METHODS TO PREVENT OR TREAT PERIODONTITIS OR PERI-IMPLANTITIS
    Publication number: 20190144856
    Abstract: Compositions and methods to prevent, inhibit or treat aveolar or periodontal bone loss, enhance bone regeneration, prevent, inhibit or treat peri-implantitis or periodontitis, e.g., periodontitis or peri-implantitis associated with bone loss, or to prevent, inhibit or treat osteoarthritis are provided.
    Type: Application
    Filed: January 15, 2016
    Publication date: May 16, 2019
    Applicant: University of Iowa Research Foundation
    Inventors: Liu HONG, Brad A. AMENDT, Aliasger K. SALEM, Satheesh ELANGOVAN, Gustavo Avila Ortiz, Thad SHARP
  • MicroRNA-200 based approaches for modulating bone formation inhibition and bone regeneration
    Patent number: 10273476
    Abstract: In certain embodiments, the present invention provides the use of microRNA (miR)-200a and/or miR-200c to inhibit ossification and bone formation. In certain embodiments, the present invention provides the use of miR-200a inhibitor to stimulate bone regeneration.
    Type: Grant
    Filed: May 1, 2017
    Date of Patent: April 30, 2019
    Assignee: University of Iowa Research Foundation
    Inventors: Liu Hong, Brad Amendt, Thad Sharp, Aliasger Salem
  • METHODS TO GENERATE EPITHELIAL CELLS
    Publication number: 20170321190
    Abstract: The invention provides in certain embodiments, a method of generating a re-programmed differentiated epithelial cell comprising (a) contacting a non-stem somatic cell obtained from a subject with an effective amount of a de-differentiation agent to form a de-differentiated cell, and (b) transfecting the de-differentiated cell with an expression cassette comprising a promoter operably linked to a nucleic acid encoding a conversion agent to form a re-programmed differentiated cell. The invention also provides in certain embodiments, a method of generating a re-programmed differentiated epithelial cell comprising (a) contacting a non-stem somatic cell obtained from a subject with an effective amount of a de-differentiation agent to form a de-differentiated cell, and (b) contacting the de-differentiated cell with a conversion agent to form a re-programmed differentiated cell.
    Type: Application
    Filed: August 13, 2015
    Publication date: November 9, 2017
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Brad A. Amendt, Thad Sharp
  • MICRORNA-200 BASED APPROACHES FOR MODULATING BONE FORMATION INHIBITION AND BONE REGENERATION
    Publication number: 20170314020
    Abstract: In certain embodiments, the present invention provides the use of microRNA (miR)-200a and/or miR-200c to inhibit ossification and bone formation. In certain embodiments, the present invention provides the use of miR-200a inhibitor to stimulate bone regeneration.
    Type: Application
    Filed: May 1, 2017
    Publication date: November 2, 2017
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Liu Hong, Brad Amendt, Thad Sharp, Aliasger Salem
  • MICRORNA INHIBITOR SYSTEM AND METHODS OF USE THEREOF
    Publication number: 20170306326
    Abstract: The present invention relates to plasmid-based miR inhibitory systems (PMIS), miR inhibitors and methods of use of these systems and inhibitors.
    Type: Application
    Filed: September 8, 2015
    Publication date: October 26, 2017
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Brad A. Amendt, Huojun Cao