Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: The present application relates to techniques for proactively monitoring and detecting failures associated with downlinking data during satellite passes. In some embodiments, first data representing a performance of a hardware device during a satellite pass may be obtained and performance metrics may be computed based on the first data. Second data may be generated based on the performance metrics and a first machine learning model may be used to determine changepoints within the second data and times associated with each changepoint. A second machine learning model may be used to determine a likelihood that the satellite pass will be successful based on at least one of the quantity of changepoints or the times associated with each changepoint, and a quality of service (QoS) score of a client may be updated based on the likelihood.

Abstract: A device for creating a fistula between blood vessels operates in conjunction with a guidewire to locate and position itself so that it straddles both vessels and is able to draw them together. A fixing agent is released either from within the device or from an external needle, or both, into the procedural site. The fixing agent functions to hold the relative position of the two vessels, to seal the surrounding tissue so that any leaks that do occur don't spread into the tissue to create a hematoma, and to limit expansion of the fistula. After the vessels are in close proximity to each other and the fixing agent is applied, the device of the invention employs a cutting mechanism which opens a portal between the two vessels.

Abstract: Described herein are systems, methods, media, and devices for generating a satellite program for contacting satellites. In some embodiments, data including one or more targets for accessing a satellite constellation is obtained. Based on the data, a set of representations may be generated and candidate satellite constellation access programs may be determined based on the set of representations. For each program, a first score may be computed for each target to obtain a first set of scores, and a second score may be computed for each first score of the first set of scores to obtain a second set of scores. A satellite constellation access program may be selected from the candidate satellite access programs based on the second set of second scores.

Abstract: Described herein are systems, methods, media, and devices for generating a satellite program for contacting satellites. In some embodiments, data including one or more targets for accessing a satellite constellation is obtained. Based on the data, a set of representations may be generated and candidate satellite constellation access programs may be determined based on the set of representations. For each program, a first score may be computed for each target to obtain a first set of scores, and a second score may be computed for each first score of the first set of scores to obtain a second set of scores. A satellite constellation access program may be selected from the candidate satellite access programs based on the second set of second scores.

Abstract: Described herein are systems, methods, media, and devices for generating a satellite program for contacting satellites. In some embodiments, data including one or more targets for accessing a satellite constellation is obtained. Based on the data, a set of representations may be generated and candidate satellite constellation access programs may be determined based on the set of representations. For each program, a first score may be computed for each target to obtain a first set of scores, and a second score may be computed for each first score of the first set of scores to obtain a second set of scores. A satellite constellation access program may be selected from the candidate satellite access programs based on the second set of second scores.

Abstract: The present teachings is generally directed to systems and methods for facilitating communications with a satellite. In some embodiments, a request to communicate with a satellite may be received from a client device, and upon determining that a device identifier associated with the client device is associated with an account authorized to connect to one or more satellite ground stations, a schedule of activity for the account may be retrieved. The schedule of activity may indicate a time period that the client device is authorized to connect to the satellite ground station(s) such that data is communicated between the satellite and the client device, and the satellite ground station(s) may be configured to communicate with the satellite. At a start of the time period, a connection between the client device and the satellite ground station(s) may be generated, and via the connection, data may be provided to the client device.

Abstract: Systems, methods, and computer-readable media are disclosed for ring-shaped devices with voice integration. In one embodiment, an example device may include an antenna element that at least partially forms an outer surface of the ring-shaped device, an outer shell coupled to the antenna element, an inner shell coupled to the outer shell, a curved battery disposed along a first side of the ring-shaped device, and a flexible printed circuit assembly coupled to the curved battery and disposed along a second side of the ring shaped device.

Abstract: Systems, methods, and computer-readable media are disclosed for systems and methods for initiating automated actions using ring-shaped electronic devices. Example methods may include determining, by a ring-shaped electronic device comprising a button, a first user interaction with the button, determining that a first action associated with the first button sequence identifier is to initiate a synchronous communication, determining contact information associated with the first action, and initiating the synchronous communication using the contact information.

Abstract: The present teachings is generally directed to systems and methods for facilitating communications with a satellite. In some embodiments, a request to communicate with a satellite may be received from a client device, and upon determining that a device identifier associated with the client device is associated with an account authorized to connect to one or more satellite ground stations, a schedule of activity for the account may be retrieved. The schedule of activity may indicate a time period that the client device is authorized to connect to the satellite ground station(s) such that data is communicated between the satellite and the client device, and the satellite ground station(s) may be configured to communicate with the satellite. At a start of the time period, a connection between the client device and the satellite ground station(s) may be generated, and via the connection, data may be provided to the client device.

Abstract: The present teachings is generally directed to systems and methods for facilitating communications with a satellite. In some embodiments, a request to communicate with a satellite may be received from a client device, and upon determining that a device identifier associated with the client device is associated with an account authorized to connect to one or more satellite ground stations, a schedule of activity for the account may be retrieved. The schedule of activity may indicate a time period that the client device is authorized to connect to the satellite ground station(s) such that data is communicated between the satellite and the client device, and the satellite ground station(s) may be configured to communicate with the satellite. At a start of the time period, a connection between the client device and the satellite ground station(s) may be generated, and via the connection, data may be provided to the client device.

Abstract: The present teachings is generally directed to systems and methods for facilitating communications with a satellite. In some embodiments, a request to communicate with a satellite may be received from a client device, and upon determining that a device identifier associated with the client device is associated with an account authorized to connect to one or more satellite ground stations, a schedule of activity for the account may be retrieved. The schedule of activity may indicate a time period that the client device is authorized to connect to the satellite ground station(s) such that data is communicated between the satellite and the client device, and the satellite ground station(s) may be configured to communicate with the satellite. At a start of the time period, a connection between the client device and the satellite ground station(s) may be generated, and via the connection, data may be provided to the client device.

Abstract: Systems, methods, and computer-readable media are disclosed for ring-shaped devices with voice integration. In one embodiment, an example device may include an antenna element that at least partially forms an outer surface of the ring-shaped device, an outer shell coupled to the antenna element, an inner shell coupled to the outer shell, a curved battery disposed along a first side of the ring-shaped device, and a flexible printed circuit assembly coupled to the curved battery and disposed along a second side of the ring shaped device.

Abstract: Systems, methods, and computer-readable media are disclosed for ring-shaped devices with voice integration. In one embodiment, an example device may include an antenna element that at least partially forms an outer surface of the ring-shaped device, an outer shell coupled to the antenna element, an inner shell coupled to the outer shell, a curved battery disposed along a first side of the ring-shaped device, and a flexible printed circuit assembly coupled to the curved battery and disposed along a second side of the ring shaped device.

Abstract: A portable rack for drying or storing articles, and a support arm device therefor. The support arm devices are pivotably secured to an external post so that the support arm can be pivoted from a supportive position to a position of non-use.

Abstract: Portable work stations which permit a one-step, touch-free finishing of all surfaces of doors, shutters, window sashes, cabinet doors, garage doors, spindles, and other workpieces. There are also provided trim measuring and cutting, and hinge mortising and prep racks, a leg assembly, a drying rack, and a trim board work station. All of these devices are provided by kits of components.