Patents by Inventor Brad J. Thacker

Brad J. Thacker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 43 Kd protein vaccine and method for the production thereof
    Patent number: 6656477
    Abstract: A protein derivable from Actinobacillus pleuropneumoniae (APP) having a molecular size ranging between 43 Kd on SDS PAGE is described. The protein is soluble on sodium lauryl sarcosinate (SLS) and not heat modifiable. The protein can also be derived by recombinant methods. The protein in a vaccine provides immunity against multiple serotypes of APP.
    Type: Grant
    Filed: July 28, 1992
    Date of Patent: December 2, 2003
    Assignee: Board of Trustees of Michigan State University
    Inventors: Martha H. Mulks, Brad J. Thacker, Maria Wilma T. Cruz
  • Method for producing a bacterial vaccine and novel vaccines produced thereby
    Patent number: 6022728
    Abstract: A new method for the preparation of a whole cell bacterial vaccine for improved protection against bacterial pathogens, particularly against those pathogens which have multiple antigenic serotypes is described. The method particularly involves disruption of the whole cells using a French press of the whole cells of virulent strains of the bacteria. The preferred vaccine prevented infection of swine with Actinobacillus pleuropneumoniae (APP), which causes porcine contagious pleuropneumonia. The vaccine has good safety and few side effects even at a higher dose than commonly used for bacterins and improved protection against the homologous serotype of the pathogen; and improved cross-protection against heterologous serotypes. The whole cell vaccine, is most useful for veterinary (lower mammal) vaccines.
    Type: Grant
    Filed: November 10, 1997
    Date of Patent: February 8, 2000
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Martha H. Mulks, Brad J. Thacker
  • 43 Kd protein vaccine and method for the production thereof
    Patent number: 5911996
    Abstract: A protein derivable from Actinobacillus pleuropneumoniae (APP) having a molecular size ranging between 43 Kd on SDS PAGE is described. The protein is soluble on sodium lauryl sarcosinate (SLS) and not heat modifiable. The protein can also be derived by recombinant methods. The protein in a vaccine provides immunity against multiple serotypes of APP.
    Type: Grant
    Filed: January 14, 1998
    Date of Patent: June 15, 1999
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Martha H. Mulks, Brad J. Thacker, Maria Wilma T. Cruz
  • 43 Kd protein vaccine and method for the production thereof
    Patent number: 5879952
    Abstract: A protein derivable from Actinobacillus pleuropneumoniae (APP) having a molecular size ranging between 43 Kd on SDS PAGE is described. The protein is soluble on sodium lauryl sarcosinate (SLS) and not heat modifiable. The protein can also be derived by recombinant methods. The protein in a vaccine provides immunity against multiple serotypes of APP.
    Type: Grant
    Filed: January 25, 1994
    Date of Patent: March 9, 1999
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Martha H. Mulks, Brad J. Thacker, Maria Wilma T. Cruz
  • Method for producing a bacterial vaccine and novel vaccines produced thereby
    Patent number: 5688682
    Abstract: A new method for the preparation of a whole cell bacterial vaccine for improved protection against bacterial pathogens, particularly against those pathogens which have multiple antigenic serotypes is described. The method particularly involves selective sonication of the whole cells of virulent strains of the bacteria. The preferred vaccine prevented infection of swine with Actinobacillus pleuropneumoniae (APP), which causes porcine contagious pleuropneumonia. The vaccine has good safety and few side effects even at a higher dose than commonly used for bacterins and improved protection against the homologous serotype of the pathogen; and improved cross-protection against heterologous serotypes. The whole cell vaccine, is most useful for veterinary (lower mammal) vaccines.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: November 18, 1997
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Martha H. Mulks, Brad J. Thacker
  • 43 Kd protein vaccine and method for the production thereof
    Patent number: 5543304
    Abstract: A protein derivable from Actinobacillus pleuropneumoniae (APP) having a molecular size ranging between 43 Kd on SDS PAGE is described. The protein is soluble on sodium lauryl sarcosinate (SLS) and not heat modifiable. The protein can also be derived by recombinant methods. The protein in a vaccine provides immunity against multiple serotypes of APP.
    Type: Grant
    Filed: April 14, 1994
    Date of Patent: August 6, 1996
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Martha H. Mulks, Brad J. Thacker, Maria W. T. Cruz