Abstract: The present invention discloses a system and method for providing targeted advertising in a television distribution system, without the disclosure of personally identifiable information. The system of the present invention comprises an advertisement management system (AMS) operative to monitor the state of one or more clients in the television distribution system and determine when a advertisement is required. The AMS is operative to select one or more features that do not comprise personally identifiable information from a feature repository. The system also comprises an advertisement selection system (ADS) operative to receive the one or more features from the AMS and select an advertisement targeted according to the one or more features.

Abstract: Compositions and methods for preventing and treating pneumococcal infections are provided. Compositions include novel polypeptides comprising an amino acid sequence corresponding to the R21 or R22 domain of CbpA or a consensus sequence of one of these domains, and variants and fragments thereof, wherein the polypeptide is stabilized in a desired conformation, particularly a loop conformation. The polypeptides of the invention may be engineered to comprise a first and a second cysteine residue, thereby resulting in the formation of a disulfide bond that stabilizes the polypeptide in the desired conformation. Alternatively, a polypeptide of the invention may be modified to create a synthetic linkage between a first and second amino acid residue present within the polypeptide, wherein the synthetic linkage stabilizes the polypeptide in the desired conformation. The polypeptides of the invention may further comprise an amino acid sequence for a T cell epitope.

Abstract: Compositions and methods for preventing and treating pneumococcal infections are provided. Compositions include novel polypeptides comprising an amino acid sequence corresponding to the R21 or R22 domain of CbpA or a consensus sequence of one of these domains, and variants and fragments thereof, wherein the polypeptide is stabilized in a desired conformation, particularly a loop conformation. The polypeptides of the invention may be engineered to comprise a first and a second cysteine residue, thereby resulting in the formation of a disulfide bond that stabilizes the polypeptide in the desired conformation. Alternatively, a polypeptide of the invention may be modified to create a synthetic linkage between a first and second amino acid residue present within the polypeptide, wherein the synthetic linkage stabilizes the polypeptide in the desired conformation. The polypeptides of the invention may further comprise an amino acid sequence for a T cell epitope.

Abstract: The present invention discloses a system and method for providing targeted advertising in a television distribution system, without the disclosure of personally identifiable information. The system of the present invention comprises an advertisement management system (AMS) operative to monitor the state of one or more clients in the television distribution system and determine when a advertisement is required. The AMS is operative to select one or more features that do not comprise personally identifiable information from a feature repository. The system also comprises an advertisement selection system (ADS) operative to receive the one or more features from the AMS and select an advertisement targeted according to the one or more features.

Abstract: Compositions and methods for preventing and treating pneumococcal infections are provided. Compositions include novel polypeptides comprising an amino acid sequence corresponding to the R2i or R22 domain of CbpA or a consensus sequence of one of these domains, and variants and fragments thereof, wherein the polypeptide is stabilized in a desired conformation, particularly a loop conformation. The polypeptides of the invention may be engineered to comprise a first and a second cysteine residue, thereby resulting in the formation of a disulfide bond that stabilizes the polypeptide in the desired conformation. Alternatively, a polypeptide of the invention may be modified to create a synthetic linkage between a first and second amino acid residue present within the polypeptide, wherein the synthetic linkage stabilizes the polypeptide in the desired conformation. The polypeptides of the invention may further comprise an amino acid sequence for a T cell epitope.

Abstract: The present invention discloses a system and method for providing targeted advertising in a television distribution system, without the disclosure of personally identifiable information. The system of the present invention comprises an advertisement management system (AMS) operative to monitor the state of one or more clients in the television distribution system and determine when a advertisement is required. The AMS is operative to select one or more features that do not comprise personally identifiable information from a feature repository. The system also comprises an advertisement selection system (ADS) operative to receive the one or more features from the AMS and select an advertisement targeted according to the one or more features.

Abstract: The present invention is directed to systems and methods for employing canonical metadata to describe advertisements comprising an advertiser storing an advertisement and arbitrarily complex metadata that is descriptive of the advertisement, which is received at a control center. At the control center, the advertisement is mapped to canonical metadata. The advertisement and canonical metadata are stored at the control center for use in discriminating between advertisements from a plurality of advertisers.

Abstract: The present invention is directed to systems and methods for creating a program for delivery to a client in a video time shifting architecture. The system of the present comprises an advertisement selection system (ADS) operative to select one or more advertisements and transmit one or more identifiers that uniquely identify the selected advertisements and an advertisement management system (AMS) operative to generate a playlist that identifies content. The playlist includes a user requested time shifted program and the one or more selected advertisements. A video server is operative to interpret the playlist and deliver the content to the user.

Abstract: Compositions and methods for preventing and treating pneumococcal infections are provided. Compositions include novel polypeptides comprising an amino acid sequence corresponding to the R2i or R22 domain of CbpA or a consensus sequence of one of these domains, and variants and fragments thereof, wherein the polypeptide is stabilized in a desired conformation, particularly a loop conformation. The polypeptides of the invention may be engineered to comprise a first and a second cysteine residue, thereby resulting in the formation of a disulfide bond that stabilizes the polypeptide in the desired conformation. Alternatively, a polypeptide of the invention may be modified to create a synthetic linkage between a first and second amino acid residue present within the polypeptide, wherein the synthetic linkage stabilizes the polypeptide in the desired conformation. The polypeptides of the invention may further comprise an amino acid sequence for a T cell epitope.

Abstract: A system for enabling the insertion and removal of an embolic protection device, for capturing and retaining embolic debris which can be created during the performance of a therapeutic interventional procedure in a stenosed or occluded region of a blood vessel. The system, in an embodiment thereof, is capable of enabling at least one operator to control the delivery and removal of an embolic protection device to a position in a patient's vasculature distal to an interventional procedure site, to enable the exchange of the delivery and recovery system. The system, in another embodiment thereof, includes a delivery system and a recovery system which are capable of enabling the delivery and recovery of an embolic protection device so as to maintain a clinically acceptable profile and flexibility through the patient's vasculature.

Abstract: A system for enabling the insertion and removal of an embolic protection device, for capturing and retaining embolic debris which may be created during the performance of a therapeutic interventional procedure in a stenosed or occluded region of a blood vessel. The system, in an embodiment thereof, is capable of enabling at least one operator to control the delivery and removal of an embolic protection device to a position in a patient's vasculature distal to an interventional procedure site, to enable the exchange of the delivery and recovery system. The system, in another embodiment thereof, includes a delivery system and a recovery system which are capable of enabling the delivery and recovery of an embolic protection device so as to maintain a clinically acceptable profile and flexibility through the patient's vasculature.

Abstract: The present invention is directed to systems and methods for employing canonical metadata to describe advertisements comprising an advertiser storing an advertisement and arbitrarily complex metadata that is descriptive of the advertisement, which is received at a control center. At the control center, the advertisement is mapped to canonical metadata. The advertisement and canonical metadata are stored at the control center for use in discriminating between advertisements from a plurality of advertisers.

Abstract: The present invention discloses a system and method for providing targeted advertising in a television distribution system, without the disclosure of personally identifiable information. The system of the present invention comprises an advertisement management system (AMS) operative to monitor the state of one or more clients in the television distribution system and determine when a advertisement is required. The AMS is operative to select one or more features that do not comprise personally identifiable information from a feature repository. The system also comprises an advertisement selection system (ADS) operative to receive the one or more features from the AMS and select an advertisement targeted according to the one or more features.

Abstract: The present invention is directed to systems and methods for creating a program for delivery to a client in a video time shifting architecture. The system of the present comprises an advertisement selection system (ADS) operative to select one or more advertisements and transmit one or more identifiers that uniquely identify the selected advertisements and an advertisement management system (AMS) operative to generate a playlist that identifies content. The playlist includes a user requested time shifted program and the one or more selected advertisements. A video server is operative to interpret the playlist and deliver the content to the user.