Patents by Inventor Brad L. Pentelute

Brad L. Pentelute has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for delivering agents into cells using bacterial toxins
    Patent number: 9079952
    Abstract: The invention provides compositions and methods for delivering a bioactive moiety comprising at least one non-natural component into a cell cytosol of an eukaryotic cell. The bioactive moiety is linked to an A component of a bacterial toxin, a functional wild-type or modified fragment thereof, or an A component surrogate or mimetic. For delivery, the cell is contacted with the linked bioactive moiety and a corresponding B component of the bacterial toxin or a functional fragment thereof.
    Type: Grant
    Filed: January 10, 2012
    Date of Patent: July 14, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Robert J. Collier, Brad L. Pentelute
  • METHOD FOR DELIVERING AGENTS INTO CELLS USING BACTERIAL TOXINS
    Publication number: 20130336974
    Abstract: The invention provides compositions and methods for delivering a bioactive moiety comprising at least one non-natural component into a cell cytosol of an eukaryotic cell. The bioactive moiety is linked to an A component of a bacterial toxin, a functional wild-type or modified fragment thereof, or an A component surrogate or mimetic. For delivery, the cell is contacted with the linked bioactive moiety and a corresponding B component of the bacterial toxin or a functional fragment thereof.
    Type: Application
    Filed: January 10, 2012
    Publication date: December 19, 2013
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Robert J. Collier, Brad L. Pentelute