Abstract: This disclosure relates to systems and methods for managing patients of knee surgeries. A pre-operative patient questionnaire user interface is associated with a future knee operation of the patient. Patient input data is indicative of answers of a patient in relation to the pre-operative patient questionnaire. A processor of a computer system evaluates a statistical model to determine a predicted satisfaction value indicative of satisfaction of the patient with the future knee operation. The statistical model comprises nodes stored on data memory representing the patient input data and the predicted satisfaction value, and edges stored on data memory between the nodes representing conditional dependencies between the patient input data and the predicted satisfaction value. The processor then generates an electronic document comprising a surgeon report associated with the future knee operation to indicate to the surgeon the predicted satisfaction value.

Abstract: This disclosure relates to surgical instruments for alignment of bone cuts during surgeries on joints and in particular, during total replacement of joints. The surgical instrument comprises a contact surface shaped to fit a prepared end of the first bone of the joint and an artificial articular surface that imitates the native articular surface of the first bone that has been removed by the preparation of the first bone. The artificial articular surface is pivotable in relation to the surgical instrument. The instrument can be fitted onto the prepared bone and coronal balancing can be performed. After fixing a further instrument to the second bone the joint can be balanced in flexion. At the optimal flexion angle, the slope and the cutting depth can be adjusted to achieve alignment. The further instrument is then used as a guide for cutting the second bone at the resulting cutting depth, slope and varus/valgus angle.

Abstract: Compositions and methods for the treatment and/or prevention and/or control of indications such as pain management, cancer, seizure disorders, and Parkinson's Disease using continuous drug delivery.

Abstract: This disclosure relates to an intraoperative localisation system for total joint replacement of a joint of a patient by a surgeon, the joint being associated with a bone. The localisation system comprises: an X-ray imaging device to create a digital X-ray image of the joint and a localisation object during a total joint replacement surgery; a computer system configured to: store a surgical plan comprising a digital three-dimensional model; receive the digital X-ray image of the joint and the localisation object during the total joint replacement surgery; determine a pose of the localisation object relative to the bone or the joint, based on the digital X-ray image; assess the pose of the localisation object against the surgical plan; and provide an indication of a clinical consequence of the pose in relation to the surgical plan to the surgeon.

Abstract: This disclosure relates to an intraoperative guidance system for total joint replacement of a joint of a patient by a surgeon. The guidance system comprises: an X-ray imaging device for single-shot application of X-ray radiation to the joint and for etecting X-ray radiation to create a digital image of the joint and an implant component during a total joint replacement surgery; and a computer system configured to: store a digital three-dimensional model of the joint; receive the digital image during the total joint replacement surgery; perform registration between the digital image and the digital three-dimensional model to determine a placement of the implant component in the digital image in relation to the digital three-dimensional model; determine an intraoperative simulated erformance metric and provide an indication to the surgeon of the intraoperative simulated performance metric as an assessment of a current placement of the implant component.

Abstract: This disclosure relates to systems for assisting surgeons in implanting joint replacement implant components. One aspect provides a system for assisting a surgeon in implanting a joint replacement implant component during a surgery of replacing a joint. The system comprises: an instrument for medullary canal preparation; a video camera to capture image data of the instrument; a computer system to: store a surgical plan; determine a pose of the instrument relative to the bone or the joint based on the image data from the video camera; assess the pose of the instrument against the surgical plan; and provide an indication to the surgeon of a clinical consequence of the pose in relation to the surgical plan.

Abstract: This disclosure relates to an intraoperative guidance system. The guidance system comprises: an X-ray imaging device to create a two-dimensional digital image of a joint and an implant component; and a computer system configured to: store an initial three-dimensional model of the joint and the implant component; receive two or more two-dimensional digital images of the joint and the implant component; create a digital three-dimensional model of the joint and the implant component based on the two or more two-dimensional digital images; perform registration between the digital three-dimensional model and the initial three-dimensional model to determine a placement of the implant component; determine an intraoperative simulated performance metric by simulating movement of the digital three-dimensional model based on the placement; and provide an indication to a surgeon of the intraoperative simulated performance metric as an assessment of a current placement of the implant component.

Abstract: This disclosure relates to surgical instruments for alignment of bone cuts during surgeries on joints and in particular, during total replacement of joints. The surgical instrument comprises a contact surface shaped to fit a prepared end of the first bone of the joint and an artificial articular surface that imitates the native articular surface of the first bone that has been removed by the preparation of the first bone. The artificial articular surface is pivotable in relation to the surgical instrument. The instrument can be fitted onto the prepared bone and coronal balancing can be performed. After fixing a further instrument to the second bone the joint can be balanced in flexion. At the optimal flexion angle, the slope and the cutting depth can be adjusted to achieve alignment. The further instrument is then used as a guide for cutting the second bone at the resulting cutting depth, slope and varus/valgus angle.

Abstract: This disclosure relates to methods and systems to assist in surgery of a joint. The system determines a mechanical property of one or more ligaments associated with the joint based on measurement data indicative of a movement of the bones relative to each other under multiple mechanical loads. The system then determines a predicted characteristic of the joint after the surgery based on a spatial parameter of the surgery and based on the mechanical property of the one or more ligaments and generates an output signal indicative of the predicted characteristic to assist the surgery. Since the predicted characteristic of the joint is determined based on the mechanical property of the ligaments, the prediction is more accurate than other methods that rely on only bone geometries to predict a surgery outcome.

Abstract: This disclosure relates to systems and methods for managing patients of knee surgeries. A pre-operative patient questionnaire user interface is associated with a future knee operation of the patient. Patient input data is indicative of answers of a patient in relation to the pre-operative patient questionnaire. A processor of a computer system evaluates a statistical model to determine a predicted satisfaction value indicative of satisfaction of the patient with the future knee operation. The statistical model comprises nodes stored on data memory representing the patient input data and the predicted satisfaction value, and edges stored on data memory between the nodes representing conditional dependencies between the patient input data and the predicted satisfaction value. The processor then generates an electronic document comprising a surgeon report associated with the future knee operation to indicate to the surgeon the predicted satisfaction value.

Abstract: This disclosure relates to systems and methods for managing patients of knee surgeries. A pre-operative patient questionnaire user interface is associated with a future knee operation of the patient. Patient input data is indicative of answers of a patient in relation to the pre-operative patient questionnaire. A processor of a computer system evaluates a statistical model to determine a predicted satisfaction value indicative of satisfaction of the patient with the future knee operation. The statistical model comprises nodes stored on data memory representing the patient input data and the predicted satisfaction value, and edges stored on data memory between the nodes representing conditional dependencies between the patient input data and the predicted satisfaction value. The processor then generates an electronic document comprising a surgeon report associated with the future knee operation to indicate to the surgeon the predicted satisfaction value.

Abstract: This disclosure relates to systems and methods for managing patients of knee surgeries. A pre-operative patient questionnaire user interface is associated with a future knee operation of the patient. Patient input data is indicative of answers of a patient in relation to the pre-operative patient questionnaire. A processor of a computer system evaluates a statistical model to determine a predicted satisfaction value indicative of satisfaction of the patient with the future knee operation. The statistical model comprises nodes stored on data memory representing the patient input data and the predicted satisfaction value, and edges stored on data memory between the nodes representing conditional dependencies between the patient input data and the predicted satisfaction value. The processor then generates an electronic document comprising a surgeon report associated with the future knee operation to indicate to the surgeon the predicted satisfaction value.

Abstract: This disclosure relates to methods and systems to assist in surgery of a joint. The system determines a mechanical property of one or more ligaments associated with the joint based on measurement data indicative of a movement of the bones relative to each other under multiple mechanical loads. The system then determines a predicted characteristic of the joint after the surgery based on a spatial parameter of the surgery and based on the mechanical property of the one or more ligaments and generates an output signal indicative of the predicted characteristic to assist the surgery. Since the predicted characteristic of the joint is determined based on the mechanical property of the ligaments, the prediction is more accurate than other methods that rely on only bone geometries to predict a surgery outcome.