Patents by Inventor Brad Pentelute

Brad Pentelute has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Convergent synthesis of proteins by kinetically controlled ligation
    Patent number: 7674881
    Abstract: The present invention concerns methods and compositions for synthesizing a polypeptide using kinetically controlled reactions involving fragments of the polypeptide for a fully convergent process. In more specific embodiments, a ligation involves reacting a first peptide having a protected cysteyl group at its N-terminal and a phenylthioester at its C-terminal with a second peptide having a cysteine residue at its N-termini and a thioester at its C-termini to form a ligation product. Subsequent reactions may involve deprotecting the cysteyl group of the resulting ligation product and/or converting the thioester into a thiophenylester.
    Type: Grant
    Filed: October 10, 2006
    Date of Patent: March 9, 2010
    Assignee: The University of Chicago
    Inventors: Stephen Kent, Brad Pentelute, Duhee Bang, Erik Johnson, Thomas Durek
  • Convergent synthesis of proteins by kinetically controlled ligation
    Publication number: 20070082378
    Abstract: The present invention concerns methods and compositions for synthesizing a polypeptide using kinetically controlled reactions involving fragments of the polypeptide for a fully convergent process. In more specific embodiments, a ligation involves reacting a first peptide having a protected cysteyl group at its N-terminal and a phenylthioester at its C-terminal with a second peptide having a cysteine residue at its N-termini and a thioester at its C-termini to form a ligation product. Subsequent reactions may involve deprotecting the cysteyl group of the resulting ligation product and/or converting the thioester into a thiophenylester.
    Type: Application
    Filed: October 10, 2006
    Publication date: April 12, 2007
    Applicant: University of Chicago
    Inventors: Stephen Kent, Duhee Bang, Brad Pentelute, Thomas Durek, Erik Johnson