Abstract: A method of hydraulically actuating downhole equipment includes supplying pressure P(z) to a downhole network comprising tools T(n), tool T(x), control lines C(z), and control lines Y(z), wherein n and z are integers, and x=n+1, wherein a pressure P(z) is applied to tool T(n) using at least one control line C(z) in hydraulic communication with tool T(n); applying pressure P(z) to a hydraulically movable portion of tool T(n), wherein pressure P(z) to tool T(n) is not high enough to independently activate tool T(x); and applying each pressure P(z) to a hydraulically movable portion of tool T(x), wherein tool T(x) is only activated when all of pressures P(z) are simultaneously applied to the hydraulically movable portion of tool T(x), and wherein tool T(x) is only activated when each pressure P(z) is at least at a preset value PV(z).

Abstract: A method of hydraulically actuating downhole equipment includes supplying pressure P(z) to a downhole network comprising tools T(n), tool T(x), control lines C(z), and control lines Y(z), wherein n and z are integers, and x=n+1, wherein a pressure P(z) is applied to tool T(n) using at least one control line C(z) in hydraulic communication with tool T(n); applying pressure P(z) to a hydraulically movable portion of tool T(n), wherein pressure P(z) to tool T(n) is not high enough to independently activate tool T(x); and applying each pressure P(z) to a hydraulically movable portion of tool T(x), wherein tool T(x) is only activated when all of pressures P(z) are simultaneou.sly applied to the hydraulically movable portion of tool T(x), and wherein tool T(x) is only activated when each pressure P(z) is at least at a preset value PV(z).

Abstract: Techniques for sealing an annulus between a well tool and a tubular include moving the well tool through a wellbore in a run-in position, the well tool including a seal and a sleeve carried on the mandrel, and covering, in the run-in position, an exterior surface of the seal opposite an interior surface of the seal that faces the mandrel; landing the well tool in a tubular that includes a shoulder on an inner surface of the tubular and a seal bore on the inner surface of the tubular, the sleeve adjacent the shoulder upon landing the well tool; and receiving a force that moves a portion of the well tool further downhole to expose at least a part of the seal to the inner surface of the tubular to create a seal between an exterior surface of the well tool and the inner surface of the tubular.

Abstract: Compounds of Formula I and methods of treating diseases of metabolism by modulating cellular NAD+ levels through the inhibition of the CD38 enzyme, are disclosed.

Abstract: Compounds of Formula I and methods of treating diseases of metabolism by modulating cellular NAD+ levels through the inhibition of the CD38 enzyme, are disclosed.