Abstract: The disclosure provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests, including Lepidopteran and Coleopteran. Particular embodiments of the disclosure provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Methods, non-transitory machine readable media, and computing devices that ensure correctness of file system analytics are disclosed. With this technology, a first generation number for a volume is incremented in response to a modification of a rule set that defines properties of objects of a file system associated with the volume. A determination is made when a second generation number in a first inode for a first one of the objects matches the first generation number. The first inode is identified based on a traversal of a directory tree associated with the file system. The modified rule set is applied to the properties for the first one of the objects to obtain values, when the second generation number fails to match the first generation number. Analytics data is output after the traversal has completed. The analytics data is generated in response to a query and is based on the values.

Abstract: The disclosure provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests, including Lepidopteran and Coleopteran. Particular embodiments of the disclosure provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.

Abstract: A tooth brush includes a handle, a shank attached to the handle and having a housing, a casing disposed in the housing, and a paddle wheel rotatably received in the casing and having a shaft extended out of the casing. A rotary brush device is attached to the shaft of the paddle wheel, and includes a number of brush members for teeth brushing purposes. A water supplying device may be used to supply water into the casing, to drive and to rotate the paddle wheel relative to the casing, and to drive the brush members of the rotary brush device to brush teeth. The casing includes a cover having one or more orifices for allowing water to flow out through the orifices of the cover of the casing.