Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Oil-based or fat-based carriers or solvents are replaced in whole or in part by a supercritical fluid or high pressure gas as a spray medium or carrier for food additives or food enhancers. Reduced fat, low fat, and even no-fat food products may be produced by topically applying the additive or enhancer using a supercritical fluid as a fat or oil replacement. Post baking or post cooking application of the food additives or enhancers substantially reduces the loss of the additives or enhancers due to heat decomposition or a volatilization in the production of food products such as baked goods, snacks, and nuts. Food additives or enhancers which may be topically applied to the food substrates include flavorants, colorants, moisture barriers, vitamins and minerals, and odorants or fragrances.